PIERGENTILI, Alessandro
 Distribuzione geografica
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Continente #
NA - Nord America 10.002
EU - Europa 5.575
AS - Asia 2.481
SA - Sud America 192
Continente sconosciuto - Info sul continente non disponibili 39
AF - Africa 28
OC - Oceania 12
Totale 18.329
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Nazione #
US - Stati Uniti d'America 9.686
CN - Cina 1.647
RU - Federazione Russa 1.472
IT - Italia 1.008
DE - Germania 922
SG - Singapore 525
PL - Polonia 405
UA - Ucraina 384
SE - Svezia 362
CA - Canada 308
GB - Regno Unito 265
FI - Finlandia 261
BR - Brasile 171
FR - Francia 159
TR - Turchia 121
IE - Irlanda 97
CZ - Repubblica Ceca 84
BE - Belgio 48
EU - Europa 37
IN - India 30
NL - Olanda 30
VN - Vietnam 26
IR - Iran 21
JP - Giappone 18
HR - Croazia 12
RO - Romania 12
AU - Australia 11
HK - Hong Kong 11
PK - Pakistan 10
ZA - Sudafrica 10
IQ - Iraq 9
EG - Egitto 8
AE - Emirati Arabi Uniti 6
AT - Austria 6
RS - Serbia 6
UZ - Uzbekistan 6
BY - Bielorussia 5
GR - Grecia 5
ID - Indonesia 5
LT - Lituania 5
PT - Portogallo 5
AR - Argentina 4
AZ - Azerbaigian 4
CL - Cile 4
IL - Israele 4
KR - Corea 4
MY - Malesia 4
PA - Panama 4
PE - Perù 4
BG - Bulgaria 3
CH - Svizzera 3
CO - Colombia 3
ES - Italia 3
HU - Ungheria 3
KG - Kirghizistan 3
KH - Cambogia 3
MA - Marocco 3
MX - Messico 3
PH - Filippine 3
QA - Qatar 3
SA - Arabia Saudita 3
TH - Thailandia 3
A2 - ???statistics.table.value.countryCode.A2??? 2
AL - Albania 2
BD - Bangladesh 2
DK - Danimarca 2
DZ - Algeria 2
EC - Ecuador 2
IS - Islanda 2
JO - Giordania 2
KE - Kenya 2
LV - Lettonia 2
SN - Senegal 2
TW - Taiwan 2
UY - Uruguay 2
CY - Cipro 1
EE - Estonia 1
GE - Georgia 1
JM - Giamaica 1
KZ - Kazakistan 1
LA - Repubblica Popolare Democratica del Laos 1
LK - Sri Lanka 1
MN - Mongolia 1
NO - Norvegia 1
NZ - Nuova Zelanda 1
PY - Paraguay 1
TN - Tunisia 1
VE - Venezuela 1
Totale 18.329
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Città #
Woodbridge 1.039
Fairfield 955
Jacksonville 955
Chandler 756
Ann Arbor 599
Ashburn 572
Houston 558
Wilmington 534
Boardman 404
Seattle 381
Nanjing 333
Cambridge 307
Warsaw 272
Dearborn 233
Toronto 225
Singapore 222
Camerino 202
Beijing 157
San Mateo 152
Düsseldorf 143
Helsinki 140
Kraków 129
Lawrence 128
Princeton 128
Nanchang 116
Columbus 105
Istanbul 101
Moscow 98
Dublin 97
Ogden 97
Kunming 86
Lachine 80
Los Angeles 73
Shanghai 73
Shenyang 73
London 70
Brno 66
Jiaxing 57
Guangzhou 53
New York 52
Tianjin 52
Jinan 50
Brussels 46
Milan 45
Venezia 45
Hebei 44
Changsha 37
San Diego 36
Redwood City 34
Hangzhou 33
Munich 33
Philadelphia 33
Wuhan 28
Falls Church 27
Hefei 27
Zhengzhou 27
Leawood 25
Washington 25
Venice 24
Taizhou 22
Centro 21
Ningbo 21
Chicago 19
Bremen 18
Nürnberg 18
Council Bluffs 17
Monmouth Junction 17
Dong Ket 16
Fuzhou 16
Nuremberg 16
Orange 16
Perugia 16
Verona 16
Old Bridge 15
Olomouc 15
Dronten 14
Kocaeli 14
Ardabil 13
Auburn Hills 13
Buffalo 13
Lanzhou 13
Norwalk 13
São Paulo 13
Changchun 12
Nantong 12
Tulsa 12
Yiwu 11
Enterprise 10
Espoo 10
Hanover 10
Pesaro 10
Shenzhen 10
Augusta 9
Baotou 9
Buti 9
Rome 9
Chongqing 8
Frankfurt am Main 8
Horia 8
Mountain View 8
Totale 12.042
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Nome #
1,4-DIOXANE NUCLEUS AS A SUITABLE SCAFFOLD FOR NOVEL D2-LIKE RECEPTOR LIGANDS 295
1,4-Dioxane, a Suitable Scaffold for the Development of Novel M3 Muscarinic Receptor Antagonists 291
The Versatile 2-Substituted Imidazoline Nucleus as a Structural Motif of Ligands Directed to the Serotonin 5-HT1A Receptor 270
Antagonism/Agonism modulation to build novel antihypertensives selectively triggering i1-imidazoline receptor activation 264
1-[3-(4-Butylpiperidin-1-yl)propyl]-1,2,3,4-tetrahydroquinolin-2-one (77-LH-28-1) as a Model for the Rational Design of a Novel Class of Brain Penetrant Ligands with High Affinity and Selectivity for Dopamine D4 Receptor 260
TP53 mutant MDM2-amplified cell lines selected for resistance to MDM2-p53 binding antagonists retain sensitivity to ionizing radiation 255
Novel Potent N-Methyl-d-aspartate (NMDA) Receptor Antagonists or σ1 Receptor Ligands Based on Properly Substituted 1,4-Dioxane Ring 248
A Novel Class of Dopamine D4 Receptor Ligands Bearing an Imidazoline Nucleus 235
1,4-Dioxane ring as a promising template of novel 5-HT1A full agonists 232
Combined Interactions with I1-, I2-Imidazoline Binding Sites and α2-Adrenoceptors To Manage Opioid Addiction 231
1,4-Dioxane nucleus as a suitable scaffold in the building of ligands interacting with NMDA and σ1 receptors 226
1'-Benzyl-3,4-dihydrospiro[2H-1-benzothiopyran-2,4'-piperidine] (Spipethiane), a potent and highly selective sigma1 lingand 225
Novel antitumor copper(ii) complexes designed to act through synergistic mechanisms of action, due to the presence of an NMDA receptor ligand and copper in the same chemical entity 215
Novel ligands rationally designed for characterizing I2-imidazoline binding sites nature and functions 207
Synthesis and antimuscarinic activity of derivatives of 2-substituted-1,3-dioxolanes 201
Receptor Ligands as Helping Hands to L-DOPA in the Treatment of Parkinson's Disease 200
33rd camerino-Cyprus Symposium - Receptor Chemistry: Reality and Vision 199
The replacement of the 2-methoxy substituent of N-((6,6-diphenyl-1,4-dioxan-2-yl)methyl)-2-(2-methoxyphenoxy)ethan-1-amine improves the selectivity for 5-HT1A receptor over α1-adrenoceptor and D2-like receptor subtypes 195
31st Camerino-Cyprus-Noordwijkerhout Symposium - Receptor Chemistry Skyline 186
Discovery of Highly Selective Imidazoline Receptor Ligands 185
Favourable involvement of α2A-adrenoreceptor antagonism in the I₂-imidazoline binding sites-mediated morphine analgesia enhancement. 185
Identification of 2-aminopyrimidine derivatives as inhibitors of the canonical Wnt signaling pathway 184
Multitarget 1,4-Dioxane Compounds Combining Favorable D2-like and 5-HT1A Receptor Interactions with Potential for the Treatment of Parkinson's Disease or Schizophrenia 183
2-(2-Phenylcyclopropyl)imidazolines: Reversed Enantioselective Interaction at I1 and I2 Imidazoline Receptors 182
Investigation of the Role of Chirality in the Interaction with σ Receptors and Effect on Binge Eating Episode of a Potent σ1 Antagonist Analogue of Spipethiane 177
Mode of interaction of 1,4-dioxane agonists at the M2 and M3 muscarinic receptor orthosteric sites 170
Rapid novel divergent synthesis and muscarinic agonist profile of all four optical isomers of N,N,N-trimethyl(6-methyl-1,4-dioxan-2-yl)methanaminium iodide. 167
alpha(2)-Adrenoreceptors profile modulation. 2. Biphenyline analogues as tools for selective activation of the alpha2C-subtype 164
Imidazoline binding sites (IBS) profile modulation: Key role of the bridge in determining I1-IBS or I2-IBS selectivity within a series of 2-phenoxymethylimidazoline analogues 163
Dopamine D-5 receptors: A challenge to medicinal chemists 162
Role of the NMDA Receptor in the Antitumor Activity of Chiral 1,4-Dioxane Ligands in MCF-7 and SKBR3 Breast Cancer Cells 161
14th Camerino-Noordwijkerhout Symposium - Ongoing Progress in Receptor Chemistry 160
Roles of Wnt/β-catenin signalling pathway in the bony repair of injured growth plate cartilage in young rats 160
Deoxamuscaroneoxime Devatives as useful Muscarinic Aginist to Explore the Muscarinic Subsite: Demox, Amodulator of Orthosteric and Allosteric Site at Cardiac Muscarinic M2 Receptors. 159
Novel Highly Potent and Selective σ1 Receptor Antagonists Related to Spipethiane 159
Structure−Activity Relationships in 1,4-Benzodioxan-Related Compounds. 11.1 Reversed Enantioselectivity of 1,4-Dioxane Derivatives in α1‑Adrenergic and 5‑HT1A Receptor Binding Sites Recognition 159
Synthesis and Biological Evaluation of a Novel Series of Heterobivalent Muscarinic Ligands Based on Xanomeline and 1‑[3- (4-Butylpiperidin-1-yl)propyl]-1,2,3,4-tetrahydroquinolin-2-one (77- LH-28-1) 157
Muscarinic Thioligands with Cyclopentane Nucleus 156
Use of frozen sections for the pharmacological characterization of compounds active on neurotransmitter receptors 155
Potent muscarinic antagonists bearing 1,4-dioxane scaffold 155
Properly substituted 1,4-dioxane nucleus favours the selective M3 muscarinic receptor activation 154
Homoazanicotine: A structure-affinity study for nicotinic acetylcholine (nACh) receptor binding 153
Novel 1,4-dioxane derivatives as NMDA receptor channel blockers 153
Binding of nicotine and homoazanicotine analogues at neuronal nicotinic acetylcholinergic (nACh) receptors 153
Muscarinic subtypes profile modulation within a series of new antagonists, bridged bicyclic derivatives of 2,2-diphenyl-[1,3]-dioxolan-4-ylmethyl-dimethylamine 152
Chemical manipulations on the 1,4-dioxane ring of 5-HT1A receptor agonists lead to antagonists endowed with antitumor activity in prostate cancer cells 151
Low doses of allyphenyline and cyclomethyline, effective against morphine dependence, elicit an antidepressant-like effect 150
Synthesis and muscarinic properties of (1S*,3R*,5R*)-trimethyl(1-methyl-6-oxabicyclo[3.1.0]hex-3-yl)methyl ammonium iodide 149
Chain-lengthened and imidazoline analogues of nicotine 148
Structurally diverse MDM2–p53 antagonists act as modulators of MDR-1 function in neuroblastoma 148
Synthesis and dopamine receptor affinities of 2-(4-fluoro-3-hydroxyphenyl)ethylamine and N-substituted derivatives 148
Dioxane and Oxathiane Nuclei: Suitable Substructures for Muscarinic Agonists 147
Synthesis, molecular modeling, and pharmacological testing of bis-quinolinium cyclophanes: Potent, non-peptidic blockers of the apamin-sensitive Ca2+-activated K+ channel 147
Design, Synthesis and Biological Evaluation of Novel Chemical Entities as Potential Anticancer Drugs and for the Control of the Metastatic Process 146
Exploring multitarget interactions to reduce opiate withdrawal syndrome and psychiatric comorbidity 143
Structure-activity relationships in 1,4-benzodioxan-related compounds. 7. Selectivity of 4-phenylchroman analogues for alpha(1)-adrenoreceptor subtypes 142
Synthesis and pharmacological testing of polyaminoquinolines as blockers of the apamin-sensitive Ca2+-activated K+ channel (SKCa) 142
Topical antiinflammatory activity of complexes of escin and sterols with phospholipids. Part I. 141
Synthesis and Structure-Activity Relationship Studies in a Series of 2-Substituted 1,3-Dioxolanes Modified at the Cationic Head. 141
33rd Camerino-Cyprus Symposium - Receptor Chemistry: Reality and Vision 140
Alpha(2)-Adrenoreceptors Profile Modulation. 3. (R)-(+)-m-Nitrobiphenyline, a New Efficient and alpha(2C)-Subtype Selective Agonist. 139
Might Adrenergic alpha2C-agonists/alpha2A-antagonists become novel therapeutic tools for pain treatment with morphine? 139
Synthesis, Absolute Configuration, and Biological Profile of the Enantiomers of trans-[2-(2,6-Dimethoxypheoxy)ethyl] [(3-p-tolyl-2,3-dihydro-1,4-benzodioxin-2-yl)methyl]amine (Mephendioxan), a Potent Competitive alpha 1A-Adrenoreceptor Antagonist 137
31st Camerino-Cyprus-Noordwijkerhout Symposium - Receptor Chemistry Skyline 137
Evaluation of an Agonist Index: Affinity Ratio for Compounds Active on Muscarinic Cholinergic M2 Receptors 136
28th Camerino-Cyprus-Noordwijkerhout Symposium - Trekking through Receptor Chemistry 136
Inhibition of WNT-β-catenin signalling promotes cartilage repair at injured growth plate in young rats 135
Solution-phase synthesis of ICG-001, a beta-turn peptidomimetic molecule inhibitor of beta-catenin-Tcf-mediated transcription 134
The 2-substituted imidazoline ring linked to an aromatic moiety by a biatomic bridge: a bioversatile scaffold 134
Allyphenyline analogues potentially useful in the management of chronic pain and opioid addiction. 132
Design, synthesis and muscarinic activity of deoxamuscarine-related derivatives 132
Fruitful Adrenergic alpha(2C)-Agonism/alpha(2A)-Antagonism Combination to Prevent and Contrast Morphine Tolerance and Dependence 130
16th Camerino-Noordwijkerhout Symposium - An Overview of Receptor Chemistry 129
TESTING D2-LIKE RECEPTOR AFFINITY AND SELECTIVITY WITH NOVEL IMIDAZOLINE DERIVATIVES 129
77-LH-28-1 as a model for the rational design of selective dopamine D4 receptor ligands 129
Imidazoline receptors: Qualitative structure-activity relationships and discovery of tracizoline and benazoline. Two ligands with high affinity and unprecedented selectivity 129
null 129
Ligand binding to I2 imidazoline receptor: the role of lipophilicity in quantitative structure-activity relationship models 127
Alpha(2)-adrenoreceptors profile modulation and high antinociceptive activity of (S)-(-)-2-[1-(biphenyl-2-yloxy)ethyl]-4,5-dihydro-1H-imidazole 126
Novel Potent 5-HT1a Agonists Selective over alpha1-Adrenoceptor Subtypes 126
Structure-activity relationships in 1,4-benzodioxan-related compounds. 8.(1) {2-[2-(4 chlorobenzyloxy)phenoxy]ethyl}-[2-(2,6-dimethoxyphenoxy)ethyl]amine (clopenphendioxan) as a tool to highlight the involvement of alpha1D- and alpha1B-adrenoreceptor subtypes in the regulation of human PC-3 prostate cancer cell apoptosis and proliferation 126
Novel muscarinic acetylcholine receptor hybrid ligands embedding quinuclidine and 1,4-dioxane fragments 124
Rational design of novel I1-imidazoline receptor agonists 120
alpha(2)-adrenoreceptors profile modulation. 4. From antagonist, to agonist behavior 119
From benzodioxane to 1,4-dioxane scaffold in the design of 5-HT1A serotoninergic full agonists from α1-adrenergic antagonists 118
Agonists and antagonists targeting the different alpha(2)-adrenoceptor subtypes 118
Synthesis and Muscarinic Receptors Affinity of a series of Antagonist Bivalent Ligands 118
Synthesis and muscarinic activity of some muscarone analogs 117
Structure- Activity Relationships in 1,4-Benzodioxan-related Compounds. 4. Effect of aryl and alkyl Substituents at Position 3 on α-adrenoreceptor blocking activity 115
DOPAMINE D2, D3, AND D4 RECEPTOR AFFINITIES OF 77-LH-28-1 AND ITS ANALOGUES 115
4WD to Travel Inside the 5-HT1A Receptor World 115
Enantioselective interactions to improve adrenergic α2C-agonism/α2A-antagonism 114
NOVEL BIVALENT LIGANDS OF XANOMELINE AND 77-LH-28-1 AS POTENTIAL M1 MUSCARINIC AGONISTS 114
Imidazoline nucleus as a biologically versatile scaffold 113
Might adrenergic α2C-agonist/α2A-antagonist become a novel therapeutic multitarget tool for morphine chronic treatment of pain? 113
Byciclic dioxolanes as potential antimuscarinic agents 112
Pharmacophore development and 3D-QSAR study of I1 imidazoline binding site ligands 112
Structure-activity relationships in 1,4-benzodioxan-related compounds. 9.From 1,4-benzodioxan to 1,4-dioxane ring as a promising template of novel alpha(1D)-adrenoreceptor antagonists, 5-HT1A full agonists, and cytotoxic agents. 112
MORPHINE TOLERANCE MODULATION INDUCED BY alpha2-ADRENERGIC OR/AND I2 IMIDAZOLINE BINDING SITES LIGANDS 111
Molecular determinants in the binding of novel 1,4-benzodioxan-related α1D-adrenergic receptor antagonists: a computational study 109
Totale 15.846
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Categoria #
all - tutte 74.105
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 74.105
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2019/2020671 0 0 0 0 0 0 0 0 194 191 83 203
2020/20212.447 138 219 179 223 163 150 302 68 205 123 448 229
2021/20221.426 127 330 20 89 109 80 42 98 109 169 87 166
2022/20232.041 240 68 96 297 214 257 14 132 376 121 146 80
2023/20241.432 190 86 95 43 54 132 61 46 144 56 40 485
2024/20253.267 196 100 379 207 127 241 561 1.098 358 0 0 0
Totale 18.682