PIERGENTILI, Alessandro
 Distribuzione geografica
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Continente #
NA - Nord America 9.514
EU - Europa 3.790
AS - Asia 1.342
Continente sconosciuto - Info sul continente non disponibili 39
SA - Sud America 11
OC - Oceania 10
AF - Africa 7
Totale 14.713
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Nazione #
US - Stati Uniti d'America 9.207
CN - Cina 1.222
IT - Italia 904
DE - Germania 870
PL - Polonia 405
UA - Ucraina 386
SE - Svezia 359
CA - Canada 305
GB - Regno Unito 263
FI - Finlandia 229
FR - Francia 155
IE - Irlanda 95
BE - Belgio 41
EU - Europa 37
IN - India 23
IR - Iran 21
NL - Olanda 21
VN - Vietnam 21
RU - Federazione Russa 16
TR - Turchia 16
RO - Romania 12
AU - Australia 10
JP - Giappone 8
ZA - Sudafrica 6
HK - Hong Kong 5
RS - Serbia 5
CL - Cile 4
KR - Corea 4
PT - Portogallo 4
AE - Emirati Arabi Uniti 3
BR - Brasile 3
GR - Grecia 3
IL - Israele 3
LT - Lituania 3
SG - Singapore 3
A2 - ???statistics.table.value.countryCode.A2??? 2
BG - Bulgaria 2
BY - Bielorussia 2
CH - Svizzera 2
CZ - Repubblica Ceca 2
DK - Danimarca 2
ES - Italia 2
HU - Ungheria 2
IS - Islanda 2
KH - Cambogia 2
MY - Malesia 2
PE - Perù 2
TH - Thailandia 2
UZ - Uzbekistan 2
AR - Argentina 1
AT - Austria 1
DZ - Algeria 1
EE - Estonia 1
ID - Indonesia 1
IQ - Iraq 1
MN - Mongolia 1
MX - Messico 1
NO - Norvegia 1
PA - Panama 1
QA - Qatar 1
SA - Arabia Saudita 1
VE - Venezuela 1
Totale 14.713
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Città #
Woodbridge 1.048
Fairfield 975
Jacksonville 959
Chandler 761
Ann Arbor 601
Houston 572
Ashburn 544
Wilmington 541
Seattle 392
Nanjing 332
Cambridge 317
Warsaw 272
Dearborn 233
Toronto 224
Camerino 175
San Mateo 154
Düsseldorf 143
Lawrence 130
Princeton 130
Kraków 129
Helsinki 119
Nanchang 116
Beijing 114
Boardman 110
Columbus 106
Ogden 99
Dublin 95
Kunming 86
Lachine 80
Shenyang 70
London 68
Tianjin 52
New York 51
Jinan 49
Venezia 45
Hebei 44
Brussels 39
Jiaxing 39
Changsha 37
Milan 36
San Diego 36
Los Angeles 34
Redwood City 34
Philadelphia 33
Hangzhou 30
Falls Church 27
Hefei 26
Zhengzhou 26
Leawood 25
Washington 25
Venice 24
Guangzhou 23
Centro 21
Ningbo 21
Bremen 20
Shanghai 20
Taizhou 19
Nürnberg 18
Monmouth Junction 17
Dong Ket 16
Orange 16
Perugia 16
Verona 16
Old Bridge 15
Dronten 14
Fuzhou 14
Kocaeli 14
Ardabil 13
Auburn Hills 13
Lanzhou 13
Norwalk 13
Changchun 12
Tulsa 12
Augusta 10
Enterprise 10
Hanover 10
Pesaro 10
Baotou 9
Buffalo 9
Buti 9
Chongqing 8
Horia 8
Mountain View 8
Portland 8
Tappahannock 8
West Jordan 8
Indiana 7
Porto San Giorgio 7
Rome 7
Andover 6
Ascoli Piceno 6
Berlin 6
Council Bluffs 6
Detroit 6
New Delhi 6
Strasbourg 6
Frankfurt am Main 5
Gunzenhausen 5
Hounslow 5
Johannesburg 5
Totale 10.961
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Nome #
1,4-DIOXANE NUCLEUS AS A SUITABLE SCAFFOLD FOR NOVEL D2-LIKE RECEPTOR LIGANDS 241
The Versatile 2-Substituted Imidazoline Nucleus as a Structural Motif of Ligands Directed to the Serotonin 5-HT1A Receptor 239
TP53 mutant MDM2-amplified cell lines selected for resistance to MDM2-p53 binding antagonists retain sensitivity to ionizing radiation 235
1,4-Dioxane, a Suitable Scaffold for the Development of Novel M3 Muscarinic Receptor Antagonists 230
Novel Potent N-Methyl-d-aspartate (NMDA) Receptor Antagonists or σ1 Receptor Ligands Based on Properly Substituted 1,4-Dioxane Ring 223
1-[3-(4-Butylpiperidin-1-yl)propyl]-1,2,3,4-tetrahydroquinolin-2-one (77-LH-28-1) as a Model for the Rational Design of a Novel Class of Brain Penetrant Ligands with High Affinity and Selectivity for Dopamine D4 Receptor 221
Antagonism/Agonism modulation to build novel antihypertensives selectively triggering i1-imidazoline receptor activation 208
Novel antitumor copper(ii) complexes designed to act through synergistic mechanisms of action, due to the presence of an NMDA receptor ligand and copper in the same chemical entity 197
A Novel Class of Dopamine D4 Receptor Ligands Bearing an Imidazoline Nucleus 196
Combined Interactions with I1-, I2-Imidazoline Binding Sites and α2-Adrenoceptors To Manage Opioid Addiction 196
Receptor Ligands as Helping Hands to L-DOPA in the Treatment of Parkinson's Disease 185
Novel ligands rationally designed for characterizing I2-imidazoline binding sites nature and functions 178
1'-Benzyl-3,4-dihydrospiro[2H-1-benzothiopyran-2,4'-piperidine] (Spipethiane), a potent and highly selective sigma1 lingand 177
The replacement of the 2-methoxy substituent of N-((6,6-diphenyl-1,4-dioxan-2-yl)methyl)-2-(2-methoxyphenoxy)ethan-1-amine improves the selectivity for 5-HT1A receptor over α1-adrenoceptor and D2-like receptor subtypes 177
Synthesis and antimuscarinic activity of derivatives of 2-substituted-1,3-dioxolanes 168
1,4-Dioxane ring as a promising template of novel 5-HT1A full agonists 167
Identification of 2-aminopyrimidine derivatives as inhibitors of the canonical Wnt signaling pathway 165
Discovery of Highly Selective Imidazoline Receptor Ligands 164
1,4-Dioxane nucleus as a suitable scaffold in the building of ligands interacting with NMDA and σ1 receptors 161
Multitarget 1,4-Dioxane Compounds Combining Favorable D2-like and 5-HT1A Receptor Interactions with Potential for the Treatment of Parkinson's Disease or Schizophrenia 155
Rapid novel divergent synthesis and muscarinic agonist profile of all four optical isomers of N,N,N-trimethyl(6-methyl-1,4-dioxan-2-yl)methanaminium iodide. 150
33rd camerino-Cyprus Symposium - Receptor Chemistry: Reality and Vision 150
Mode of interaction of 1,4-dioxane agonists at the M2 and M3 muscarinic receptor orthosteric sites 148
Investigation of the Role of Chirality in the Interaction with σ Receptors and Effect on Binge Eating Episode of a Potent σ1 Antagonist Analogue of Spipethiane 148
2-(2-Phenylcyclopropyl)imidazolines: Reversed Enantioselective Interaction at I1 and I2 Imidazoline Receptors 147
31st Camerino-Cyprus-Noordwijkerhout Symposium - Receptor Chemistry Skyline 144
Roles of Wnt/β-catenin signalling pathway in the bony repair of injured growth plate cartilage in young rats 143
Synthesis and Biological Evaluation of a Novel Series of Heterobivalent Muscarinic Ligands Based on Xanomeline and 1‑[3- (4-Butylpiperidin-1-yl)propyl]-1,2,3,4-tetrahydroquinolin-2-one (77- LH-28-1) 141
Favourable involvement of α2A-adrenoreceptor antagonism in the I₂-imidazoline binding sites-mediated morphine analgesia enhancement. 141
Structure−Activity Relationships in 1,4-Benzodioxan-Related Compounds. 11.1 Reversed Enantioselectivity of 1,4-Dioxane Derivatives in α1‑Adrenergic and 5‑HT1A Receptor Binding Sites Recognition 140
Novel Highly Potent and Selective σ1 Receptor Antagonists Related to Spipethiane 139
Dopamine D-5 receptors: A challenge to medicinal chemists 139
Use of frozen sections for the pharmacological characterization of compounds active on neurotransmitter receptors 138
Imidazoline binding sites (IBS) profile modulation: Key role of the bridge in determining I1-IBS or I2-IBS selectivity within a series of 2-phenoxymethylimidazoline analogues 138
Synthesis and cytotoxic activity evaluation of new Cu(I) complexes of bis(pyrazol-1-yl) acetate ligands functionalized with an NMDA receptor antagonist 138
Homoazanicotine: A structure-affinity study for nicotinic acetylcholine (nACh) receptor binding 137
Properly substituted 1,4-dioxane nucleus favours the selective M3 muscarinic receptor activation 137
Binding of nicotine and homoazanicotine analogues at neuronal nicotinic acetylcholinergic (nACh) receptors 135
Dioxane and Oxathiane Nuclei: Suitable Substructures for Muscarinic Agonists 134
Synthesis and dopamine receptor affinities of 2-(4-fluoro-3-hydroxyphenyl)ethylamine and N-substituted derivatives 134
Structurally diverse MDM2–p53 antagonists act as modulators of MDR-1 function in neuroblastoma 133
Muscarinic Thioligands with Cyclopentane Nucleus 133
Chain-lengthened and imidazoline analogues of nicotine 131
Potent muscarinic antagonists bearing 1,4-dioxane scaffold 131
Muscarinic subtypes profile modulation within a series of new antagonists, bridged bicyclic derivatives of 2,2-diphenyl-[1,3]-dioxolan-4-ylmethyl-dimethylamine 130
Role of the NMDA Receptor in the Antitumor Activity of Chiral 1,4-Dioxane Ligands in MCF-7 and SKBR3 Breast Cancer Cells 130
null 129
Synthesis, molecular modeling, and pharmacological testing of bis-quinolinium cyclophanes: Potent, non-peptidic blockers of the apamin-sensitive Ca2+-activated K+ channel 128
Synthesis and muscarinic properties of (1S*,3R*,5R*)-trimethyl(1-methyl-6-oxabicyclo[3.1.0]hex-3-yl)methyl ammonium iodide 127
Low doses of allyphenyline and cyclomethyline, effective against morphine dependence, elicit an antidepressant-like effect 127
Synthesis and Structure-Activity Relationship Studies in a Series of 2-Substituted 1,3-Dioxolanes Modified at the Cationic Head. 125
alpha(2)-Adrenoreceptors profile modulation. 2. Biphenyline analogues as tools for selective activation of the alpha2C-subtype 124
Deoxamuscaroneoxime Devatives as useful Muscarinic Aginist to Explore the Muscarinic Subsite: Demox, Amodulator of Orthosteric and Allosteric Site at Cardiac Muscarinic M2 Receptors. 122
Chemical manipulations on the 1,4-dioxane ring of 5-HT1A receptor agonists lead to antagonists endowed with antitumor activity in prostate cancer cells 121
Exploring multitarget interactions to reduce opiate withdrawal syndrome and psychiatric comorbidity 120
Synthesis and pharmacological testing of polyaminoquinolines as blockers of the apamin-sensitive Ca2+-activated K+ channel (SKCa) 120
Design, Synthesis and Biological Evaluation of Novel Chemical Entities as Potential Anticancer Drugs and for the Control of the Metastatic Process 119
Novel 1,4-dioxane derivatives as NMDA receptor channel blockers 119
The 2-substituted imidazoline ring linked to an aromatic moiety by a biatomic bridge: a bioversatile scaffold 119
Structure-activity relationships in 1,4-benzodioxan-related compounds. 7. Selectivity of 4-phenylchroman analogues for alpha(1)-adrenoreceptor subtypes 118
Synthesis, Absolute Configuration, and Biological Profile of the Enantiomers of trans-[2-(2,6-Dimethoxypheoxy)ethyl] [(3-p-tolyl-2,3-dihydro-1,4-benzodioxin-2-yl)methyl]amine (Mephendioxan), a Potent Competitive alpha 1A-Adrenoreceptor Antagonist 117
Evaluation of an Agonist Index: Affinity Ratio for Compounds Active on Muscarinic Cholinergic M2 Receptors 117
14th Camerino-Noordwijkerhout Symposium - Ongoing Progress in Receptor Chemistry 117
Topical antiinflammatory activity of complexes of escin and sterols with phospholipids. Part I. 116
Inhibition of WNT-β-catenin signalling promotes cartilage repair at injured growth plate in young rats 114
Might Adrenergic alpha2C-agonists/alpha2A-antagonists become novel therapeutic tools for pain treatment with morphine? 112
Imidazoline receptors: Qualitative structure-activity relationships and discovery of tracizoline and benazoline. Two ligands with high affinity and unprecedented selectivity 109
Ligand binding to I2 imidazoline receptor: the role of lipophilicity in quantitative structure-activity relationship models 107
Solution-phase synthesis of ICG-001, a beta-turn peptidomimetic molecule inhibitor of beta-catenin-Tcf-mediated transcription 105
Alpha(2)-Adrenoreceptors Profile Modulation. 3. (R)-(+)-m-Nitrobiphenyline, a New Efficient and alpha(2C)-Subtype Selective Agonist. 104
TESTING D2-LIKE RECEPTOR AFFINITY AND SELECTIVITY WITH NOVEL IMIDAZOLINE DERIVATIVES 101
From benzodioxane to 1,4-dioxane scaffold in the design of 5-HT1A serotoninergic full agonists from α1-adrenergic antagonists 100
Fruitful Adrenergic alpha(2C)-Agonism/alpha(2A)-Antagonism Combination to Prevent and Contrast Morphine Tolerance and Dependence 100
Synthesis and muscarinic activity of some muscarone analogs 100
Novel muscarinic acetylcholine receptor hybrid ligands embedding quinuclidine and 1,4-dioxane fragments 100
Structure-activity relationships in 1,4-benzodioxan-related compounds. 8.(1) {2-[2-(4 chlorobenzyloxy)phenoxy]ethyl}-[2-(2,6-dimethoxyphenoxy)ethyl]amine (clopenphendioxan) as a tool to highlight the involvement of alpha1D- and alpha1B-adrenoreceptor subtypes in the regulation of human PC-3 prostate cancer cell apoptosis and proliferation 100
Structure- Activity Relationships in 1,4-Benzodioxan-related Compounds. 4. Effect of aryl and alkyl Substituents at Position 3 on α-adrenoreceptor blocking activity 99
alpha(2)-adrenoreceptors profile modulation. 4. From antagonist, to agonist behavior 99
Synthesis and Muscarinic Receptors Affinity of a series of Antagonist Bivalent Ligands 97
33rd Camerino-Cyprus Symposium - Receptor Chemistry: Reality and Vision 97
Alpha(2)-adrenoreceptors profile modulation and high antinociceptive activity of (S)-(-)-2-[1-(biphenyl-2-yloxy)ethyl]-4,5-dihydro-1H-imidazole 96
Design, synthesis and muscarinic activity of deoxamuscarine-related derivatives 96
31st Camerino-Cyprus-Noordwijkerhout Symposium - Receptor Chemistry Skyline 95
Molecular determinants in the binding of novel 1,4-benzodioxan-related α1D-adrenergic receptor antagonists: a computational study 94
28th Camerino-Cyprus-Noordwijkerhout Symposium - Trekking through Receptor Chemistry 93
Rational design of novel I1-imidazoline receptor agonists 92
16th Camerino-Noordwijkerhout Symposium - An Overview of Receptor Chemistry 92
Structure-activity relationships in 1,4-benzodioxan-related compounds. 9.From 1,4-benzodioxan to 1,4-dioxane ring as a promising template of novel alpha(1D)-adrenoreceptor antagonists, 5-HT1A full agonists, and cytotoxic agents. 90
Imidazoline nucleus as a biologically versatile scaffold 89
Allyphenyline analogues potentially useful in the management of chronic pain and opioid addiction. 88
Structure-activity relationships in 1,4-benzodioxan-related compounds. 10. Novel alpha1-adrenoreceptor antagonists related to openphendioxan: synthesis, biological evaluation, and alpha1d computational study 88
Design and synthesis of novel imidazoline derivatives potentially targeting dopamine receptors 87
Agonists and antagonists targeting the different alpha(2)-adrenoceptor subtypes 87
Structure-Activity Relationships in 1,4-Benzodioxan-Related Compounds. 6. Role of the Dioxane Unit on Selectivity for Alpha1-Adrenoreceptor Subtypes 87
Byciclic dioxolanes as potential antimuscarinic agents 87
Pharmacophore development and 3D-QSAR study of I1 imidazoline binding site ligands 87
Might adrenergic α2C-agonist/α2A-antagonist become a novel therapeutic multitarget tool for morphine chronic treatment of pain? 86
Copresence of 1,4-dioxane and quinuclidine nuclei in the design of novel muscarinic antagonists 85
NOVEL BIVALENT LIGANDS OF XANOMELINE AND 77-LH-28-1 AS POTENTIAL M1 MUSCARINIC AGONISTS 85
Rational design of the new antihypertensive I1-receptor ligand 2-(2-Biphenyl-2-yl-1-methyl-ethyl)-4,5-dihydro-1H-imidazole 84
Totale 13.109
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Categoria #
all - tutte 53.318
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 53.318
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2018/2019713 0 0 0 0 0 0 0 0 0 0 297 416
2019/20203.300 400 106 328 588 184 372 324 321 194 191 88 204
2020/20212.543 141 221 219 224 169 150 328 75 206 125 454 231
2021/20221.445 127 334 20 89 109 80 43 99 114 175 87 168
2022/20232.071 243 68 98 298 217 260 15 133 386 121 149 83
2023/2024922 193 89 97 44 54 133 61 46 146 56 3 0
Totale 15.056