PIERGENTILI, Alessandro
 Distribuzione geografica
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Continente #
NA - Nord America 12.983
EU - Europa 6.117
AS - Asia 4.628
SA - Sud America 593
AF - Africa 79
Continente sconosciuto - Info sul continente non disponibili 39
OC - Oceania 36
Totale 24.475
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Nazione #
US - Stati Uniti d'America 12.568
CN - Cina 2.176
RU - Federazione Russa 1.492
SG - Singapore 1.237
IT - Italia 1.095
DE - Germania 1.031
BR - Brasile 507
PL - Polonia 446
UA - Ucraina 391
SE - Svezia 390
HK - Hong Kong 385
CA - Canada 356
GB - Regno Unito 346
FI - Finlandia 320
FR - Francia 198
VN - Vietnam 186
TR - Turchia 160
KR - Corea 140
IE - Irlanda 99
CZ - Repubblica Ceca 86
IN - India 84
JP - Giappone 60
BE - Belgio 54
MX - Messico 44
ZA - Sudafrica 43
NL - Olanda 41
EU - Europa 37
AR - Argentina 36
AU - Australia 33
BD - Bangladesh 29
ES - Italia 27
IQ - Iraq 27
IR - Iran 26
EC - Ecuador 17
LT - Lituania 17
PK - Pakistan 17
ID - Indonesia 13
RO - Romania 13
AE - Emirati Arabi Uniti 12
AT - Austria 12
EG - Egitto 12
HR - Croazia 12
UZ - Uzbekistan 9
CO - Colombia 8
SA - Arabia Saudita 8
PE - Perù 7
MA - Marocco 6
PT - Portogallo 6
RS - Serbia 6
AZ - Azerbaigian 5
BY - Bielorussia 5
CH - Svizzera 5
GR - Grecia 5
IL - Israele 5
JO - Giordania 5
KE - Kenya 5
PH - Filippine 5
UY - Uruguay 5
VE - Venezuela 5
AL - Albania 4
CL - Cile 4
KG - Kirghizistan 4
MY - Malesia 4
PA - Panama 4
TH - Thailandia 4
BG - Bulgaria 3
DZ - Algeria 3
GE - Georgia 3
HU - Ungheria 3
IS - Islanda 3
KH - Cambogia 3
KZ - Kazakistan 3
NP - Nepal 3
PY - Paraguay 3
QA - Qatar 3
SN - Senegal 3
TW - Taiwan 3
A2 - ???statistics.table.value.countryCode.A2??? 2
DK - Danimarca 2
HN - Honduras 2
JM - Giamaica 2
LV - Lettonia 2
NZ - Nuova Zelanda 2
TN - Tunisia 2
TT - Trinidad e Tobago 2
AD - Andorra 1
AO - Angola 1
BH - Bahrain 1
BO - Bolivia 1
BZ - Belize 1
CR - Costa Rica 1
CY - Cipro 1
DO - Repubblica Dominicana 1
EE - Estonia 1
GA - Gabon 1
GH - Ghana 1
GT - Guatemala 1
KW - Kuwait 1
LA - Repubblica Popolare Democratica del Laos 1
LB - Libano 1
Totale 24.466
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Città #
Dallas 1.308
Woodbridge 1.039
Fairfield 955
Jacksonville 955
Ashburn 945
Chandler 756
Ann Arbor 599
Singapore 583
Houston 573
Wilmington 535
Boardman 404
Seattle 391
Hong Kong 374
Beijing 354
Nanjing 333
Cambridge 308
Warsaw 306
Dearborn 233
Toronto 233
Los Angeles 228
Camerino 208
New York 172
Düsseldorf 153
San Mateo 152
Helsinki 141
Seoul 137
Tongling 135
The Dalles 133
Kraków 129
Lawrence 128
Princeton 128
Columbus 119
Istanbul 119
Nanchang 116
Munich 107
Dublin 99
Moscow 99
Ogden 97
Buffalo 93
Kunming 86
London 82
Lachine 80
Shanghai 75
Shenyang 74
Milan 72
Brno 66
Ho Chi Minh City 66
Guangzhou 57
Jiaxing 57
Turku 54
Tianjin 53
Brussels 51
Jinan 50
São Paulo 50
Chicago 48
Tokyo 45
Venezia 45
Hebei 44
Hanoi 41
Changsha 39
Santa Clara 39
San Diego 36
Hangzhou 35
Philadelphia 34
Redwood City 34
Denver 32
Poplar 31
Stockholm 31
Zhengzhou 31
Johannesburg 28
Washington 28
Wuhan 28
Brooklyn 27
Falls Church 27
Frankfurt am Main 27
Hefei 27
Leawood 25
Montreal 25
Boston 24
Phoenix 24
Venice 24
Chennai 23
Orem 23
Taizhou 22
Centro 21
Ningbo 21
Nuremberg 21
Council Bluffs 20
Ankara 18
Bremen 18
Nürnberg 18
Rome 18
Monmouth Junction 17
Olomouc 17
Redondo Beach 17
Atlanta 16
Dong Ket 16
Fuzhou 16
Orange 16
Perugia 16
Totale 16.083
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Nome #
1,4-Dioxane, a Suitable Scaffold for the Development of Novel M3 Muscarinic Receptor Antagonists 591
1,4-DIOXANE NUCLEUS AS A SUITABLE SCAFFOLD FOR NOVEL D2-LIKE RECEPTOR LIGANDS 585
1,4-Dioxane nucleus as a suitable scaffold in the building of ligands interacting with NMDA and σ1 receptors 528
1'-Benzyl-3,4-dihydrospiro[2H-1-benzothiopyran-2,4'-piperidine] (Spipethiane), a potent and highly selective sigma1 lingand 521
1,4-Dioxane ring as a promising template of novel 5-HT1A full agonists 520
The Versatile 2-Substituted Imidazoline Nucleus as a Structural Motif of Ligands Directed to the Serotonin 5-HT1A Receptor 312
1-[3-(4-Butylpiperidin-1-yl)propyl]-1,2,3,4-tetrahydroquinolin-2-one (77-LH-28-1) as a Model for the Rational Design of a Novel Class of Brain Penetrant Ligands with High Affinity and Selectivity for Dopamine D4 Receptor 307
Antagonism/Agonism modulation to build novel antihypertensives selectively triggering i1-imidazoline receptor activation 306
Novel Potent N-Methyl-d-aspartate (NMDA) Receptor Antagonists or σ1 Receptor Ligands Based on Properly Substituted 1,4-Dioxane Ring 286
TP53 mutant MDM2-amplified cell lines selected for resistance to MDM2-p53 binding antagonists retain sensitivity to ionizing radiation 285
A Novel Class of Dopamine D4 Receptor Ligands Bearing an Imidazoline Nucleus 277
Combined Interactions with I1-, I2-Imidazoline Binding Sites and α2-Adrenoceptors To Manage Opioid Addiction 264
Novel ligands rationally designed for characterizing I2-imidazoline binding sites nature and functions 246
33rd camerino-Cyprus Symposium - Receptor Chemistry: Reality and Vision 245
31st Camerino-Cyprus-Noordwijkerhout Symposium - Receptor Chemistry Skyline 243
Novel antitumor copper(ii) complexes designed to act through synergistic mechanisms of action, due to the presence of an NMDA receptor ligand and copper in the same chemical entity 242
Synthesis and antimuscarinic activity of derivatives of 2-substituted-1,3-dioxolanes 241
Investigation of the Role of Chirality in the Interaction with σ Receptors and Effect on Binge Eating Episode of a Potent σ1 Antagonist Analogue of Spipethiane 235
2-(2-Phenylcyclopropyl)imidazolines: Reversed Enantioselective Interaction at I1 and I2 Imidazoline Receptors 234
Favourable involvement of α2A-adrenoreceptor antagonism in the I₂-imidazoline binding sites-mediated morphine analgesia enhancement. 231
Receptor Ligands as Helping Hands to L-DOPA in the Treatment of Parkinson's Disease 226
The replacement of the 2-methoxy substituent of N-((6,6-diphenyl-1,4-dioxan-2-yl)methyl)-2-(2-methoxyphenoxy)ethan-1-amine improves the selectivity for 5-HT1A receptor over α1-adrenoceptor and D2-like receptor subtypes 221
Multitarget 1,4-Dioxane Compounds Combining Favorable D2-like and 5-HT1A Receptor Interactions with Potential for the Treatment of Parkinson's Disease or Schizophrenia 221
alpha(2)-Adrenoreceptors profile modulation. 2. Biphenyline analogues as tools for selective activation of the alpha2C-subtype 220
Mode of interaction of 1,4-dioxane agonists at the M2 and M3 muscarinic receptor orthosteric sites 212
Discovery of Highly Selective Imidazoline Receptor Ligands 212
Identification of 2-aminopyrimidine derivatives as inhibitors of the canonical Wnt signaling pathway 210
Imidazoline binding sites (IBS) profile modulation: Key role of the bridge in determining I1-IBS or I2-IBS selectivity within a series of 2-phenoxymethylimidazoline analogues 209
14th Camerino-Noordwijkerhout Symposium - Ongoing Progress in Receptor Chemistry 206
Rapid novel divergent synthesis and muscarinic agonist profile of all four optical isomers of N,N,N-trimethyl(6-methyl-1,4-dioxan-2-yl)methanaminium iodide. 197
Novel 1,4-dioxane derivatives as NMDA receptor channel blockers 196
Role of the NMDA Receptor in the Antitumor Activity of Chiral 1,4-Dioxane Ligands in MCF-7 and SKBR3 Breast Cancer Cells 195
Structure-activity relationships in 1,4-benzodioxan-related compounds. 7. Selectivity of 4-phenylchroman analogues for alpha(1)-adrenoreceptor subtypes 194
33rd Camerino-Cyprus Symposium - Receptor Chemistry: Reality and Vision 194
Deoxamuscaroneoxime Devatives as useful Muscarinic Aginist to Explore the Muscarinic Subsite: Demox, Amodulator of Orthosteric and Allosteric Site at Cardiac Muscarinic M2 Receptors. 193
Dopamine D-5 receptors: A challenge to medicinal chemists 193
Novel Highly Potent and Selective σ1 Receptor Antagonists Related to Spipethiane 191
Design, Synthesis and Biological Evaluation of Novel Chemical Entities as Potential Anticancer Drugs and for the Control of the Metastatic Process 188
Muscarinic subtypes profile modulation within a series of new antagonists, bridged bicyclic derivatives of 2,2-diphenyl-[1,3]-dioxolan-4-ylmethyl-dimethylamine 188
Synthesis and muscarinic properties of (1S*,3R*,5R*)-trimethyl(1-methyl-6-oxabicyclo[3.1.0]hex-3-yl)methyl ammonium iodide 188
Chemical manipulations on the 1,4-dioxane ring of 5-HT1A receptor agonists lead to antagonists endowed with antitumor activity in prostate cancer cells 188
31st Camerino-Cyprus-Noordwijkerhout Symposium - Receptor Chemistry Skyline 187
Design, synthesis and muscarinic activity of deoxamuscarine-related derivatives 187
77-LH-28-1 as a model for the rational design of selective dopamine D4 receptor ligands 185
Use of frozen sections for the pharmacological characterization of compounds active on neurotransmitter receptors 184
Topical antiinflammatory activity of complexes of escin and sterols with phospholipids. Part I. 184
Roles of Wnt/β-catenin signalling pathway in the bony repair of injured growth plate cartilage in young rats 184
Low doses of allyphenyline and cyclomethyline, effective against morphine dependence, elicit an antidepressant-like effect 184
Homoazanicotine: A structure-affinity study for nicotinic acetylcholine (nACh) receptor binding 183
Structure−Activity Relationships in 1,4-Benzodioxan-Related Compounds. 11.1 Reversed Enantioselectivity of 1,4-Dioxane Derivatives in α1‑Adrenergic and 5‑HT1A Receptor Binding Sites Recognition 182
28th Camerino-Cyprus-Noordwijkerhout Symposium - Trekking through Receptor Chemistry 179
Potent muscarinic antagonists bearing 1,4-dioxane scaffold 178
Properly substituted 1,4-dioxane nucleus favours the selective M3 muscarinic receptor activation 177
Binding of nicotine and homoazanicotine analogues at neuronal nicotinic acetylcholinergic (nACh) receptors 177
Alpha(2)-Adrenoreceptors Profile Modulation. 3. (R)-(+)-m-Nitrobiphenyline, a New Efficient and alpha(2C)-Subtype Selective Agonist. 174
16th Camerino-Noordwijkerhout Symposium - An Overview of Receptor Chemistry 174
Might Adrenergic alpha2C-agonists/alpha2A-antagonists become novel therapeutic tools for pain treatment with morphine? 174
Synthesis and Biological Evaluation of a Novel Series of Heterobivalent Muscarinic Ligands Based on Xanomeline and 1‑[3- (4-Butylpiperidin-1-yl)propyl]-1,2,3,4-tetrahydroquinolin-2-one (77- LH-28-1) 173
Solution-phase synthesis of ICG-001, a beta-turn peptidomimetic molecule inhibitor of beta-catenin-Tcf-mediated transcription 172
Exploring multitarget interactions to reduce opiate withdrawal syndrome and psychiatric comorbidity 172
Synthesis and Structure-Activity Relationship Studies in a Series of 2-Substituted 1,3-Dioxolanes Modified at the Cationic Head. 171
4WD to Travel Inside the 5-HT1A Receptor World 171
Muscarinic Thioligands with Cyclopentane Nucleus 170
Allyphenyline analogues potentially useful in the management of chronic pain and opioid addiction. 169
Synthesis and dopamine receptor affinities of 2-(4-fluoro-3-hydroxyphenyl)ethylamine and N-substituted derivatives 169
Novel Potent 5-HT1a Agonists Selective over alpha1-Adrenoceptor Subtypes 168
Synthesis, Absolute Configuration, and Biological Profile of the Enantiomers of trans-[2-(2,6-Dimethoxypheoxy)ethyl] [(3-p-tolyl-2,3-dihydro-1,4-benzodioxin-2-yl)methyl]amine (Mephendioxan), a Potent Competitive alpha 1A-Adrenoreceptor Antagonist 167
Chain-lengthened and imidazoline analogues of nicotine 166
Dioxane and Oxathiane Nuclei: Suitable Substructures for Muscarinic Agonists 166
Alpha(2)-adrenoreceptors profile modulation and high antinociceptive activity of (S)-(-)-2-[1-(biphenyl-2-yloxy)ethyl]-4,5-dihydro-1H-imidazole 165
Structurally diverse MDM2–p53 antagonists act as modulators of MDR-1 function in neuroblastoma 165
Synthesis, molecular modeling, and pharmacological testing of bis-quinolinium cyclophanes: Potent, non-peptidic blockers of the apamin-sensitive Ca2+-activated K+ channel 164
Evaluation of an Agonist Index: Affinity Ratio for Compounds Active on Muscarinic Cholinergic M2 Receptors 163
Fruitful Adrenergic alpha(2C)-Agonism/alpha(2A)-Antagonism Combination to Prevent and Contrast Morphine Tolerance and Dependence 162
Structure-activity relationships in 1,4-benzodioxan-related compounds. 8.(1) {2-[2-(4 chlorobenzyloxy)phenoxy]ethyl}-[2-(2,6-dimethoxyphenoxy)ethyl]amine (clopenphendioxan) as a tool to highlight the involvement of alpha1D- and alpha1B-adrenoreceptor subtypes in the regulation of human PC-3 prostate cancer cell apoptosis and proliferation 161
Ligand binding to I2 imidazoline receptor: the role of lipophilicity in quantitative structure-activity relationship models 160
Synthesis and pharmacological testing of polyaminoquinolines as blockers of the apamin-sensitive Ca2+-activated K+ channel (SKCa) 159
Novel highly potent and selective sigma1 receptor antagonists effectively block the binge eating episode in female rats 159
alpha(2)-adrenoreceptors profile modulation. 4. From antagonist, to agonist behavior 158
DOPAMINE D2, D3, AND D4 RECEPTOR AFFINITIES OF 77-LH-28-1 AND ITS ANALOGUES 158
Novel muscarinic acetylcholine receptor hybrid ligands embedding quinuclidine and 1,4-dioxane fragments 158
The 2-substituted imidazoline ring linked to an aromatic moiety by a biatomic bridge: a bioversatile scaffold 158
Inhibition of WNT-β-catenin signalling promotes cartilage repair at injured growth plate in young rats 157
Enantioselective interactions to improve adrenergic α2C-agonism/α2A-antagonism 156
TESTING D2-LIKE RECEPTOR AFFINITY AND SELECTIVITY WITH NOVEL IMIDAZOLINE DERIVATIVES 156
NOVEL BIVALENT LIGANDS OF XANOMELINE AND 77-LH-28-1 AS POTENTIAL M1 MUSCARINIC AGONISTS 156
Agonists and antagonists targeting the different alpha(2)-adrenoceptor subtypes 154
Imidazoline receptors: Qualitative structure-activity relationships and discovery of tracizoline and benazoline. Two ligands with high affinity and unprecedented selectivity 154
Rational design of novel I1-imidazoline receptor agonists 153
Might adrenergic α2C-agonist/α2A-antagonist become a novel therapeutic multitarget tool for morphine chronic treatment of pain? 153
From benzodioxane to 1,4-dioxane scaffold in the design of 5-HT1A serotoninergic full agonists from α1-adrenergic antagonists 150
Pharmacophore development and 3D-QSAR study of I1 imidazoline binding site ligands 149
Byciclic dioxolanes as potential antimuscarinic agents 146
Rational design of new alpha(2)-adrenoreceptor agonists 144
Structure-activity relationships in 1,4-benzodioxan-related compounds. 9.From 1,4-benzodioxan to 1,4-dioxane ring as a promising template of novel alpha(1D)-adrenoreceptor antagonists, 5-HT1A full agonists, and cytotoxic agents. 144
Structure- Activity Relationships in 1,4-Benzodioxan-related Compounds. 4. Effect of aryl and alkyl Substituents at Position 3 on α-adrenoreceptor blocking activity 143
Synthesis and Muscarinic Receptors Affinity of a series of Antagonist Bivalent Ligands 141
Imidazoline nucleus as a biologically versatile scaffold 140
Synthesis and muscarinic activity of some muscarone analogs 137
MORPHINE TOLERANCE MODULATION INDUCED BY alpha2-ADRENERGIC OR/AND I2 IMIDAZOLINE BINDING SITES LIGANDS 137
Totale 20.628
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Categoria #
all - tutte 94.970
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 94.970
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/20211.525 0 0 0 0 0 150 302 68 205 123 448 229
2021/20221.426 127 330 20 89 109 80 42 98 109 169 87 166
2022/20232.041 240 68 96 297 214 257 14 132 376 121 146 80
2023/20241.432 190 86 95 43 54 132 61 46 144 56 40 485
2024/20254.631 196 100 379 207 127 241 561 1.098 370 292 313 747
2025/20264.788 436 523 1.574 1.056 769 430 0 0 0 0 0 0
Totale 24.834