PIERGENTILI, Alessandro
 Distribuzione geografica
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Continente #
NA - Nord America 15.381
EU - Europa 6.552
AS - Asia 5.767
SA - Sud America 645
Continente sconosciuto - Info sul continente non disponibili 406
AF - Africa 229
OC - Oceania 50
Totale 29.030
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Nazione #
US - Stati Uniti d'America 14.901
CN - Cina 2.375
SG - Singapore 1.660
RU - Federazione Russa 1.485
IT - Italia 1.226
DE - Germania 1.053
BR - Brasile 534
VN - Vietnam 471
PL - Polonia 458
HK - Hong Kong 444
GB - Regno Unito 396
UA - Ucraina 394
SE - Svezia 392
CA - Canada 389
FI - Finlandia 354
FR - Francia 336
ZA - Sudafrica 165
TR - Turchia 161
KR - Corea 143
IN - India 120
IE - Irlanda 105
CZ - Repubblica Ceca 86
BD - Bangladesh 79
JP - Giappone 78
NL - Olanda 60
MX - Messico 57
BE - Belgio 55
AU - Australia 47
AR - Argentina 41
EU - Europa 37
ES - Italia 36
IQ - Iraq 34
IR - Iran 31
PK - Pakistan 29
EC - Ecuador 20
EG - Egitto 19
ID - Indonesia 16
LT - Lituania 16
CO - Colombia 14
HR - Croazia 14
MA - Marocco 14
RO - Romania 14
AE - Emirati Arabi Uniti 13
AT - Austria 13
PH - Filippine 12
SA - Arabia Saudita 12
MY - Malesia 10
UZ - Uzbekistan 10
CH - Svizzera 9
VE - Venezuela 9
RS - Serbia 8
TW - Taiwan 8
AL - Albania 7
DZ - Algeria 7
JM - Giamaica 7
JO - Giordania 7
KE - Kenya 7
PE - Perù 7
CL - Cile 6
NP - Nepal 6
PT - Portogallo 6
PY - Paraguay 6
UY - Uruguay 6
AZ - Azerbaigian 5
BY - Bielorussia 5
GR - Grecia 5
HN - Honduras 5
IL - Israele 5
PA - Panama 5
SN - Senegal 5
TH - Thailandia 5
HU - Ungheria 4
KG - Kirghizistan 4
KH - Cambogia 4
TN - Tunisia 4
BG - Bulgaria 3
CR - Costa Rica 3
DO - Repubblica Dominicana 3
GE - Georgia 3
GT - Guatemala 3
IS - Islanda 3
KZ - Kazakistan 3
QA - Qatar 3
TT - Trinidad e Tobago 3
A2 - ???statistics.table.value.countryCode.A2??? 2
DK - Danimarca 2
GA - Gabon 2
LA - Repubblica Popolare Democratica del Laos 2
LB - Libano 2
LV - Lettonia 2
NI - Nicaragua 2
NZ - Nuova Zelanda 2
OM - Oman 2
PS - Palestinian Territory 2
AD - Andorra 1
AM - Armenia 1
AO - Angola 1
BH - Bahrain 1
BO - Bolivia 1
BS - Bahamas 1
Totale 28.644
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Città #
Dallas 1.331
Ashburn 1.138
Woodbridge 1.039
Jacksonville 958
Fairfield 955
Singapore 913
Chandler 756
San Jose 621
Ann Arbor 600
Houston 578
Wilmington 535
Council Bluffs 517
Hong Kong 431
Beijing 412
Boardman 405
Seattle 393
Nanjing 333
Warsaw 316
Cambridge 308
Los Angeles 257
Toronto 239
Dearborn 233
Camerino 208
New York 202
Helsinki 174
Ho Chi Minh City 169
The Dalles 169
Düsseldorf 153
San Mateo 152
Johannesburg 149
Seoul 138
Tongling 134
Kraków 129
Lawrence 128
Princeton 128
Lauterbourg 121
Columbus 120
Istanbul 119
Nanchang 116
Munich 107
Dublin 104
Orem 104
Hanoi 103
Moscow 100
Buffalo 99
Santa Clara 99
Ogden 97
Kunming 86
London 86
Lachine 80
Shanghai 79
Milan 75
Shenyang 74
Brno 66
Guangzhou 57
Jiaxing 57
Tokyo 57
Turku 54
São Paulo 53
Tianjin 53
Brussels 52
Chicago 50
Jinan 50
Venezia 45
Hebei 44
Chennai 42
Frankfurt am Main 42
Changsha 39
Phoenix 39
Hangzhou 38
Denver 36
San Diego 36
Philadelphia 35
Redwood City 34
Manchester 33
Montreal 33
Poplar 33
Zhengzhou 33
Brooklyn 32
Stockholm 32
Washington 30
Wuhan 30
Rome 28
Boston 27
Falls Church 27
Hefei 27
St Louis 26
Leawood 25
Mexico City 25
Da Nang 24
Nuremberg 24
Trieste 24
Venice 24
Amsterdam 23
Ascoli Piceno 23
Taizhou 22
Atlanta 21
Centro 21
Ningbo 21
Sydney 21
Totale 18.738
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Nome #
1,4-Dioxane nucleus as a suitable scaffold in the building of ligands interacting with NMDA and σ1 receptors 655
1,4-DIOXANE NUCLEUS AS A SUITABLE SCAFFOLD FOR NOVEL D2-LIKE RECEPTOR LIGANDS 632
1,4-Dioxane, a Suitable Scaffold for the Development of Novel M3 Muscarinic Receptor Antagonists 629
1,4-Dioxane ring as a promising template of novel 5-HT1A full agonists 564
1'-Benzyl-3,4-dihydrospiro[2H-1-benzothiopyran-2,4'-piperidine] (Spipethiane), a potent and highly selective sigma1 lingand 558
Roles of Wnt/β-catenin signalling pathway in the bony repair of injured growth plate cartilage in young rats 467
Antagonism/Agonism modulation to build novel antihypertensives selectively triggering i1-imidazoline receptor activation 344
The Versatile 2-Substituted Imidazoline Nucleus as a Structural Motif of Ligands Directed to the Serotonin 5-HT1A Receptor 336
1-[3-(4-Butylpiperidin-1-yl)propyl]-1,2,3,4-tetrahydroquinolin-2-one (77-LH-28-1) as a Model for the Rational Design of a Novel Class of Brain Penetrant Ligands with High Affinity and Selectivity for Dopamine D4 Receptor 331
31st Camerino-Cyprus-Noordwijkerhout Symposium - Receptor Chemistry Skyline 330
Novel Potent N-Methyl-d-aspartate (NMDA) Receptor Antagonists or σ1 Receptor Ligands Based on Properly Substituted 1,4-Dioxane Ring 310
TP53 mutant MDM2-amplified cell lines selected for resistance to MDM2-p53 binding antagonists retain sensitivity to ionizing radiation 306
A Novel Class of Dopamine D4 Receptor Ligands Bearing an Imidazoline Nucleus 303
Combined Interactions with I1-, I2-Imidazoline Binding Sites and α2-Adrenoceptors To Manage Opioid Addiction 294
33rd camerino-Cyprus Symposium - Receptor Chemistry: Reality and Vision 273
Novel ligands rationally designed for characterizing I2-imidazoline binding sites nature and functions 271
Synthesis and antimuscarinic activity of derivatives of 2-substituted-1,3-dioxolanes 269
Novel antitumor copper(ii) complexes designed to act through synergistic mechanisms of action, due to the presence of an NMDA receptor ligand and copper in the same chemical entity 268
2-(2-Phenylcyclopropyl)imidazolines: Reversed Enantioselective Interaction at I1 and I2 Imidazoline Receptors 266
Investigation of the Role of Chirality in the Interaction with σ Receptors and Effect on Binge Eating Episode of a Potent σ1 Antagonist Analogue of Spipethiane 262
Favourable involvement of α2A-adrenoreceptor antagonism in the I₂-imidazoline binding sites-mediated morphine analgesia enhancement. 254
The replacement of the 2-methoxy substituent of N-((6,6-diphenyl-1,4-dioxan-2-yl)methyl)-2-(2-methoxyphenoxy)ethan-1-amine improves the selectivity for 5-HT1A receptor over α1-adrenoceptor and D2-like receptor subtypes 252
Multitarget 1,4-Dioxane Compounds Combining Favorable D2-like and 5-HT1A Receptor Interactions with Potential for the Treatment of Parkinson's Disease or Schizophrenia 246
Receptor Ligands as Helping Hands to L-DOPA in the Treatment of Parkinson's Disease 244
alpha(2)-Adrenoreceptors profile modulation. 2. Biphenyline analogues as tools for selective activation of the alpha2C-subtype 240
14th Camerino-Noordwijkerhout Symposium - Ongoing Progress in Receptor Chemistry 239
Identification of 2-aminopyrimidine derivatives as inhibitors of the canonical Wnt signaling pathway 234
Mode of interaction of 1,4-dioxane agonists at the M2 and M3 muscarinic receptor orthosteric sites 230
Binding of nicotine and homoazanicotine analogues at neuronal nicotinic acetylcholinergic (nACh) receptors 230
Imidazoline binding sites (IBS) profile modulation: Key role of the bridge in determining I1-IBS or I2-IBS selectivity within a series of 2-phenoxymethylimidazoline analogues 228
Discovery of Highly Selective Imidazoline Receptor Ligands 227
Inhibition of WNT-β-catenin signalling promotes cartilage repair at injured growth plate in young rats 226
33rd Camerino-Cyprus Symposium - Receptor Chemistry: Reality and Vision 225
Novel 1,4-dioxane derivatives as NMDA receptor channel blockers 224
Deoxamuscaroneoxime Devatives as useful Muscarinic Aginist to Explore the Muscarinic Subsite: Demox, Amodulator of Orthosteric and Allosteric Site at Cardiac Muscarinic M2 Receptors. 221
Role of the NMDA Receptor in the Antitumor Activity of Chiral 1,4-Dioxane Ligands in MCF-7 and SKBR3 Breast Cancer Cells 221
77-LH-28-1 as a model for the rational design of selective dopamine D4 receptor ligands 220
Novel Highly Potent and Selective σ1 Receptor Antagonists Related to Spipethiane 218
Structure−Activity Relationships in 1,4-Benzodioxan-Related Compounds. 11.1 Reversed Enantioselectivity of 1,4-Dioxane Derivatives in α1‑Adrenergic and 5‑HT1A Receptor Binding Sites Recognition 217
Design, synthesis and muscarinic activity of deoxamuscarine-related derivatives 214
Structure-activity relationships in 1,4-benzodioxan-related compounds. 7. Selectivity of 4-phenylchroman analogues for alpha(1)-adrenoreceptor subtypes 213
31st Camerino-Cyprus-Noordwijkerhout Symposium - Receptor Chemistry Skyline 213
Rapid novel divergent synthesis and muscarinic agonist profile of all four optical isomers of N,N,N-trimethyl(6-methyl-1,4-dioxan-2-yl)methanaminium iodide. 212
Dopamine D-5 receptors: A challenge to medicinal chemists 212
Synthesis and muscarinic properties of (1S*,3R*,5R*)-trimethyl(1-methyl-6-oxabicyclo[3.1.0]hex-3-yl)methyl ammonium iodide 211
Design, Synthesis and Biological Evaluation of Novel Chemical Entities as Potential Anticancer Drugs and for the Control of the Metastatic Process 209
Muscarinic subtypes profile modulation within a series of new antagonists, bridged bicyclic derivatives of 2,2-diphenyl-[1,3]-dioxolan-4-ylmethyl-dimethylamine 208
Low doses of allyphenyline and cyclomethyline, effective against morphine dependence, elicit an antidepressant-like effect 208
Homoazanicotine: A structure-affinity study for nicotinic acetylcholine (nACh) receptor binding 207
Might Adrenergic alpha2C-agonists/alpha2A-antagonists become novel therapeutic tools for pain treatment with morphine? 207
Chemical manipulations on the 1,4-dioxane ring of 5-HT1A receptor agonists lead to antagonists endowed with antitumor activity in prostate cancer cells 207
Targeting orexin receptors: Recent advances in the development of subtype selective or dual ligands for the treatment of neuropsychiatric disorders 205
16th Camerino-Noordwijkerhout Symposium - An Overview of Receptor Chemistry 205
Alpha(2)-Adrenoreceptors Profile Modulation. 3. (R)-(+)-m-Nitrobiphenyline, a New Efficient and alpha(2C)-Subtype Selective Agonist. 204
Topical antiinflammatory activity of complexes of escin and sterols with phospholipids. Part I. 204
Properly substituted 1,4-dioxane nucleus favours the selective M3 muscarinic receptor activation 203
Use of frozen sections for the pharmacological characterization of compounds active on neurotransmitter receptors 202
28th Camerino-Cyprus-Noordwijkerhout Symposium - Trekking through Receptor Chemistry 201
4WD to Travel Inside the 5-HT1A Receptor World 201
Enantioselective interactions to improve adrenergic α2C-agonism/α2A-antagonism 196
Potent muscarinic antagonists bearing 1,4-dioxane scaffold 195
Synthesis and Biological Evaluation of a Novel Series of Heterobivalent Muscarinic Ligands Based on Xanomeline and 1‑[3- (4-Butylpiperidin-1-yl)propyl]-1,2,3,4-tetrahydroquinolin-2-one (77- LH-28-1) 195
Solution-phase synthesis of ICG-001, a beta-turn peptidomimetic molecule inhibitor of beta-catenin-Tcf-mediated transcription 194
Exploring multitarget interactions to reduce opiate withdrawal syndrome and psychiatric comorbidity 194
Chain-lengthened and imidazoline analogues of nicotine 192
Alpha(2)-adrenoreceptors profile modulation and high antinociceptive activity of (S)-(-)-2-[1-(biphenyl-2-yloxy)ethyl]-4,5-dihydro-1H-imidazole 192
Muscarinic Thioligands with Cyclopentane Nucleus 192
Allyphenyline analogues potentially useful in the management of chronic pain and opioid addiction. 191
Synthesis and dopamine receptor affinities of 2-(4-fluoro-3-hydroxyphenyl)ethylamine and N-substituted derivatives 190
NOVEL BIVALENT LIGANDS OF XANOMELINE AND 77-LH-28-1 AS POTENTIAL M1 MUSCARINIC AGONISTS 189
Novel Potent 5-HT1a Agonists Selective over alpha1-Adrenoceptor Subtypes 189
DOPAMINE D2, D3, AND D4 RECEPTOR AFFINITIES OF 77-LH-28-1 AND ITS ANALOGUES 186
Dioxane and Oxathiane Nuclei: Suitable Substructures for Muscarinic Agonists 185
Synthesis and Structure-Activity Relationship Studies in a Series of 2-Substituted 1,3-Dioxolanes Modified at the Cationic Head. 185
Ligand binding to I2 imidazoline receptor: the role of lipophilicity in quantitative structure-activity relationship models 185
Fruitful Adrenergic alpha(2C)-Agonism/alpha(2A)-Antagonism Combination to Prevent and Contrast Morphine Tolerance and Dependence 184
Novel muscarinic acetylcholine receptor hybrid ligands embedding quinuclidine and 1,4-dioxane fragments 184
Synthesis, Absolute Configuration, and Biological Profile of the Enantiomers of trans-[2-(2,6-Dimethoxypheoxy)ethyl] [(3-p-tolyl-2,3-dihydro-1,4-benzodioxin-2-yl)methyl]amine (Mephendioxan), a Potent Competitive alpha 1A-Adrenoreceptor Antagonist 183
Structurally diverse MDM2–p53 antagonists act as modulators of MDR-1 function in neuroblastoma 182
Novel highly potent and selective sigma1 receptor antagonists effectively block the binge eating episode in female rats 182
Synthesis, molecular modeling, and pharmacological testing of bis-quinolinium cyclophanes: Potent, non-peptidic blockers of the apamin-sensitive Ca2+-activated K+ channel 181
Structure-activity relationships in 1,4-benzodioxan-related compounds. 8.(1) {2-[2-(4 chlorobenzyloxy)phenoxy]ethyl}-[2-(2,6-dimethoxyphenoxy)ethyl]amine (clopenphendioxan) as a tool to highlight the involvement of alpha1D- and alpha1B-adrenoreceptor subtypes in the regulation of human PC-3 prostate cancer cell apoptosis and proliferation 181
Agonists and antagonists targeting the different alpha(2)-adrenoceptor subtypes 180
TESTING D2-LIKE RECEPTOR AFFINITY AND SELECTIVITY WITH NOVEL IMIDAZOLINE DERIVATIVES 180
Assessing the role of ghrelin and the enzyme ghrelin O-acyltransferase (GOAT) system in food reward, food motivation, and binge eating behavior 179
Advances in the Development of Nonpeptide Small Molecules Targeting Ghrelin Receptor 179
Evaluation of an Agonist Index: Affinity Ratio for Compounds Active on Muscarinic Cholinergic M2 Receptors 178
Imidazoline receptors: Qualitative structure-activity relationships and discovery of tracizoline and benazoline. Two ligands with high affinity and unprecedented selectivity 178
Synthesis and pharmacological testing of polyaminoquinolines as blockers of the apamin-sensitive Ca2+-activated K+ channel (SKCa) 176
Pharmacophore development and 3D-QSAR study of I1 imidazoline binding site ligands 176
alpha(2)-adrenoreceptors profile modulation. 4. From antagonist, to agonist behavior 176
The 2-substituted imidazoline ring linked to an aromatic moiety by a biatomic bridge: a bioversatile scaffold 176
Structure-activity relationships in 1,4-benzodioxan-related compounds. 9.From 1,4-benzodioxan to 1,4-dioxane ring as a promising template of novel alpha(1D)-adrenoreceptor antagonists, 5-HT1A full agonists, and cytotoxic agents. 175
MORPHINE TOLERANCE MODULATION INDUCED BY alpha2-ADRENERGIC OR/AND I2 IMIDAZOLINE BINDING SITES LIGANDS 174
Rational design of novel I1-imidazoline receptor agonists 173
Might adrenergic α2C-agonist/α2A-antagonist become a novel therapeutic multitarget tool for morphine chronic treatment of pain? 172
Advances in drug design and therapeutic potential of selective or multitarget 5‐HT1A receptor ligands 170
Imidazoline nucleus as a biologically versatile scaffold 168
Byciclic dioxolanes as potential antimuscarinic agents 167
From benzodioxane to 1,4-dioxane scaffold in the design of 5-HT1A serotoninergic full agonists from α1-adrenergic antagonists 166
Totale 23.680
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Categoria #
all - tutte 108.842
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 108.842
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2021/20221.299 0 330 20 89 109 80 42 98 109 169 87 166
2022/20232.041 240 68 96 297 214 257 14 132 376 121 146 80
2023/20241.438 190 86 95 43 54 132 61 46 146 56 41 488
2024/20254.611 197 100 378 207 127 240 559 1.094 369 292 313 735
2025/20268.135 436 523 1.587 1.048 773 567 1.054 479 445 533 431 259
2026/2027863 684 179 0 0 0 0 0 0 0 0 0 0
Totale 29.030