PIERGENTILI, Alessandro
 Distribuzione geografica
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Continente #
NA - Nord America 9.814
EU - Europa 3.926
AS - Asia 1.923
Continente sconosciuto - Info sul continente non disponibili 39
SA - Sud America 16
OC - Oceania 11
AF - Africa 8
Totale 15.737
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Nazione #
US - Stati Uniti d'America 9.504
CN - Cina 1.614
IT - Italia 925
DE - Germania 892
PL - Polonia 405
UA - Ucraina 382
SE - Svezia 361
CA - Canada 307
GB - Regno Unito 258
FI - Finlandia 230
SG - Singapore 165
FR - Francia 156
IE - Irlanda 97
CZ - Repubblica Ceca 84
BE - Belgio 47
EU - Europa 37
VN - Vietnam 25
IN - India 23
NL - Olanda 23
IR - Iran 21
RU - Federazione Russa 19
JP - Giappone 18
TR - Turchia 16
RO - Romania 12
AU - Australia 11
BR - Brasile 6
ZA - Sudafrica 6
HK - Hong Kong 5
ID - Indonesia 5
PT - Portogallo 5
RS - Serbia 5
AE - Emirati Arabi Uniti 4
CL - Cile 4
GR - Grecia 4
IQ - Iraq 4
KR - Corea 4
IL - Israele 3
LT - Lituania 3
A2 - ???statistics.table.value.countryCode.A2??? 2
AZ - Azerbaigian 2
BG - Bulgaria 2
BY - Bielorussia 2
CH - Svizzera 2
CO - Colombia 2
DK - Danimarca 2
ES - Italia 2
HU - Ungheria 2
IS - Islanda 2
KH - Cambogia 2
MY - Malesia 2
PE - Perù 2
TH - Thailandia 2
UZ - Uzbekistan 2
AR - Argentina 1
AT - Austria 1
DZ - Algeria 1
EE - Estonia 1
GE - Georgia 1
JM - Giamaica 1
KG - Kirghizistan 1
KZ - Kazakistan 1
LV - Lettonia 1
MA - Marocco 1
MN - Mongolia 1
MX - Messico 1
NO - Norvegia 1
PA - Panama 1
QA - Qatar 1
SA - Arabia Saudita 1
VE - Venezuela 1
Totale 15.737
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Città #
Woodbridge 1.039
Fairfield 955
Jacksonville 955
Chandler 756
Ann Arbor 599
Ashburn 560
Houston 558
Wilmington 534
Boardman 400
Seattle 381
Nanjing 333
Cambridge 307
Warsaw 272
Dearborn 233
Toronto 224
Camerino 180
Beijing 156
San Mateo 152
Düsseldorf 143
Kraków 129
Lawrence 128
Princeton 128
Helsinki 119
Nanchang 116
Columbus 105
Singapore 102
Dublin 97
Ogden 97
Kunming 86
Lachine 80
Shenyang 72
Shanghai 68
London 67
Brno 66
Jiaxing 56
Los Angeles 54
Guangzhou 53
Tianjin 52
New York 51
Jinan 50
Brussels 45
Venezia 45
Hebei 44
Changsha 37
Milan 36
San Diego 35
Redwood City 34
Hangzhou 33
Philadelphia 33
Wuhan 28
Falls Church 27
Hefei 26
Zhengzhou 26
Leawood 25
Washington 25
Venice 24
Munich 23
Taizhou 22
Centro 21
Ningbo 21
Chicago 19
Bremen 18
Nürnberg 18
Monmouth Junction 17
Dong Ket 16
Fuzhou 16
Orange 16
Perugia 16
Verona 16
Old Bridge 15
Olomouc 15
Dronten 14
Kocaeli 14
Ardabil 13
Auburn Hills 13
Lanzhou 13
Norwalk 13
Buffalo 12
Changchun 12
Tulsa 12
Yiwu 11
Enterprise 10
Hanover 10
Nantong 10
Pesaro 10
Augusta 9
Baotou 9
Buti 9
Shenzhen 9
Chongqing 8
Horia 8
Mountain View 8
Portland 8
Tappahannock 8
West Jordan 8
Hanoi 7
Indiana 7
Jinhua 7
Nuremberg 7
Porto San Giorgio 7
Totale 11.591
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Nome #
1,4-DIOXANE NUCLEUS AS A SUITABLE SCAFFOLD FOR NOVEL D2-LIKE RECEPTOR LIGANDS 263
1,4-Dioxane, a Suitable Scaffold for the Development of Novel M3 Muscarinic Receptor Antagonists 263
The Versatile 2-Substituted Imidazoline Nucleus as a Structural Motif of Ligands Directed to the Serotonin 5-HT1A Receptor 247
TP53 mutant MDM2-amplified cell lines selected for resistance to MDM2-p53 binding antagonists retain sensitivity to ionizing radiation 239
1-[3-(4-Butylpiperidin-1-yl)propyl]-1,2,3,4-tetrahydroquinolin-2-one (77-LH-28-1) as a Model for the Rational Design of a Novel Class of Brain Penetrant Ligands with High Affinity and Selectivity for Dopamine D4 Receptor 233
Novel Potent N-Methyl-d-aspartate (NMDA) Receptor Antagonists or σ1 Receptor Ligands Based on Properly Substituted 1,4-Dioxane Ring 228
Antagonism/Agonism modulation to build novel antihypertensives selectively triggering i1-imidazoline receptor activation 217
A Novel Class of Dopamine D4 Receptor Ligands Bearing an Imidazoline Nucleus 206
Combined Interactions with I1-, I2-Imidazoline Binding Sites and α2-Adrenoceptors To Manage Opioid Addiction 205
Novel antitumor copper(ii) complexes designed to act through synergistic mechanisms of action, due to the presence of an NMDA receptor ligand and copper in the same chemical entity 204
1'-Benzyl-3,4-dihydrospiro[2H-1-benzothiopyran-2,4'-piperidine] (Spipethiane), a potent and highly selective sigma1 lingand 194
Receptor Ligands as Helping Hands to L-DOPA in the Treatment of Parkinson's Disease 192
1,4-Dioxane nucleus as a suitable scaffold in the building of ligands interacting with NMDA and σ1 receptors 191
1,4-Dioxane ring as a promising template of novel 5-HT1A full agonists 187
Novel ligands rationally designed for characterizing I2-imidazoline binding sites nature and functions 185
The replacement of the 2-methoxy substituent of N-((6,6-diphenyl-1,4-dioxan-2-yl)methyl)-2-(2-methoxyphenoxy)ethan-1-amine improves the selectivity for 5-HT1A receptor over α1-adrenoceptor and D2-like receptor subtypes 184
Synthesis and antimuscarinic activity of derivatives of 2-substituted-1,3-dioxolanes 179
Identification of 2-aminopyrimidine derivatives as inhibitors of the canonical Wnt signaling pathway 172
Discovery of Highly Selective Imidazoline Receptor Ligands 168
Multitarget 1,4-Dioxane Compounds Combining Favorable D2-like and 5-HT1A Receptor Interactions with Potential for the Treatment of Parkinson's Disease or Schizophrenia 162
33rd camerino-Cyprus Symposium - Receptor Chemistry: Reality and Vision 161
2-(2-Phenylcyclopropyl)imidazolines: Reversed Enantioselective Interaction at I1 and I2 Imidazoline Receptors 157
31st Camerino-Cyprus-Noordwijkerhout Symposium - Receptor Chemistry Skyline 157
Rapid novel divergent synthesis and muscarinic agonist profile of all four optical isomers of N,N,N-trimethyl(6-methyl-1,4-dioxan-2-yl)methanaminium iodide. 156
Investigation of the Role of Chirality in the Interaction with σ Receptors and Effect on Binge Eating Episode of a Potent σ1 Antagonist Analogue of Spipethiane 154
Mode of interaction of 1,4-dioxane agonists at the M2 and M3 muscarinic receptor orthosteric sites 153
Roles of Wnt/β-catenin signalling pathway in the bony repair of injured growth plate cartilage in young rats 152
Favourable involvement of α2A-adrenoreceptor antagonism in the I₂-imidazoline binding sites-mediated morphine analgesia enhancement. 152
Structure−Activity Relationships in 1,4-Benzodioxan-Related Compounds. 11.1 Reversed Enantioselectivity of 1,4-Dioxane Derivatives in α1‑Adrenergic and 5‑HT1A Receptor Binding Sites Recognition 148
Synthesis and Biological Evaluation of a Novel Series of Heterobivalent Muscarinic Ligands Based on Xanomeline and 1‑[3- (4-Butylpiperidin-1-yl)propyl]-1,2,3,4-tetrahydroquinolin-2-one (77- LH-28-1) 147
Dopamine D-5 receptors: A challenge to medicinal chemists 147
Novel Highly Potent and Selective σ1 Receptor Antagonists Related to Spipethiane 146
Homoazanicotine: A structure-affinity study for nicotinic acetylcholine (nACh) receptor binding 144
Use of frozen sections for the pharmacological characterization of compounds active on neurotransmitter receptors 144
Properly substituted 1,4-dioxane nucleus favours the selective M3 muscarinic receptor activation 144
Imidazoline binding sites (IBS) profile modulation: Key role of the bridge in determining I1-IBS or I2-IBS selectivity within a series of 2-phenoxymethylimidazoline analogues 144
Binding of nicotine and homoazanicotine analogues at neuronal nicotinic acetylcholinergic (nACh) receptors 143
alpha(2)-Adrenoreceptors profile modulation. 2. Biphenyline analogues as tools for selective activation of the alpha2C-subtype 141
Dioxane and Oxathiane Nuclei: Suitable Substructures for Muscarinic Agonists 140
Synthesis and dopamine receptor affinities of 2-(4-fluoro-3-hydroxyphenyl)ethylamine and N-substituted derivatives 140
Muscarinic Thioligands with Cyclopentane Nucleus 140
Muscarinic subtypes profile modulation within a series of new antagonists, bridged bicyclic derivatives of 2,2-diphenyl-[1,3]-dioxolan-4-ylmethyl-dimethylamine 138
Chain-lengthened and imidazoline analogues of nicotine 138
Potent muscarinic antagonists bearing 1,4-dioxane scaffold 138
Role of the NMDA Receptor in the Antitumor Activity of Chiral 1,4-Dioxane Ligands in MCF-7 and SKBR3 Breast Cancer Cells 138
Structurally diverse MDM2–p53 antagonists act as modulators of MDR-1 function in neuroblastoma 137
Deoxamuscaroneoxime Devatives as useful Muscarinic Aginist to Explore the Muscarinic Subsite: Demox, Amodulator of Orthosteric and Allosteric Site at Cardiac Muscarinic M2 Receptors. 135
Synthesis and muscarinic properties of (1S*,3R*,5R*)-trimethyl(1-methyl-6-oxabicyclo[3.1.0]hex-3-yl)methyl ammonium iodide 134
Synthesis, molecular modeling, and pharmacological testing of bis-quinolinium cyclophanes: Potent, non-peptidic blockers of the apamin-sensitive Ca2+-activated K+ channel 134
Low doses of allyphenyline and cyclomethyline, effective against morphine dependence, elicit an antidepressant-like effect 133
Synthesis and pharmacological testing of polyaminoquinolines as blockers of the apamin-sensitive Ca2+-activated K+ channel (SKCa) 132
Chemical manipulations on the 1,4-dioxane ring of 5-HT1A receptor agonists lead to antagonists endowed with antitumor activity in prostate cancer cells 132
Synthesis and Structure-Activity Relationship Studies in a Series of 2-Substituted 1,3-Dioxolanes Modified at the Cationic Head. 130
Design, Synthesis and Biological Evaluation of Novel Chemical Entities as Potential Anticancer Drugs and for the Control of the Metastatic Process 129
null 129
Novel 1,4-dioxane derivatives as NMDA receptor channel blockers 128
14th Camerino-Noordwijkerhout Symposium - Ongoing Progress in Receptor Chemistry 127
Exploring multitarget interactions to reduce opiate withdrawal syndrome and psychiatric comorbidity 127
Structure-activity relationships in 1,4-benzodioxan-related compounds. 7. Selectivity of 4-phenylchroman analogues for alpha(1)-adrenoreceptor subtypes 126
The 2-substituted imidazoline ring linked to an aromatic moiety by a biatomic bridge: a bioversatile scaffold 126
Topical antiinflammatory activity of complexes of escin and sterols with phospholipids. Part I. 125
Synthesis, Absolute Configuration, and Biological Profile of the Enantiomers of trans-[2-(2,6-Dimethoxypheoxy)ethyl] [(3-p-tolyl-2,3-dihydro-1,4-benzodioxin-2-yl)methyl]amine (Mephendioxan), a Potent Competitive alpha 1A-Adrenoreceptor Antagonist 124
Evaluation of an Agonist Index: Affinity Ratio for Compounds Active on Muscarinic Cholinergic M2 Receptors 124
Inhibition of WNT-β-catenin signalling promotes cartilage repair at injured growth plate in young rats 123
Might Adrenergic alpha2C-agonists/alpha2A-antagonists become novel therapeutic tools for pain treatment with morphine? 120
Imidazoline receptors: Qualitative structure-activity relationships and discovery of tracizoline and benazoline. Two ligands with high affinity and unprecedented selectivity 118
Alpha(2)-Adrenoreceptors Profile Modulation. 3. (R)-(+)-m-Nitrobiphenyline, a New Efficient and alpha(2C)-Subtype Selective Agonist. 115
Solution-phase synthesis of ICG-001, a beta-turn peptidomimetic molecule inhibitor of beta-catenin-Tcf-mediated transcription 115
Ligand binding to I2 imidazoline receptor: the role of lipophilicity in quantitative structure-activity relationship models 113
Fruitful Adrenergic alpha(2C)-Agonism/alpha(2A)-Antagonism Combination to Prevent and Contrast Morphine Tolerance and Dependence 111
33rd Camerino-Cyprus Symposium - Receptor Chemistry: Reality and Vision 110
From benzodioxane to 1,4-dioxane scaffold in the design of 5-HT1A serotoninergic full agonists from α1-adrenergic antagonists 108
31st Camerino-Cyprus-Noordwijkerhout Symposium - Receptor Chemistry Skyline 108
alpha(2)-adrenoreceptors profile modulation. 4. From antagonist, to agonist behavior 108
Structure-activity relationships in 1,4-benzodioxan-related compounds. 8.(1) {2-[2-(4 chlorobenzyloxy)phenoxy]ethyl}-[2-(2,6-dimethoxyphenoxy)ethyl]amine (clopenphendioxan) as a tool to highlight the involvement of alpha1D- and alpha1B-adrenoreceptor subtypes in the regulation of human PC-3 prostate cancer cell apoptosis and proliferation 108
Synthesis and muscarinic activity of some muscarone analogs 107
Novel muscarinic acetylcholine receptor hybrid ligands embedding quinuclidine and 1,4-dioxane fragments 107
TESTING D2-LIKE RECEPTOR AFFINITY AND SELECTIVITY WITH NOVEL IMIDAZOLINE DERIVATIVES 106
Synthesis and Muscarinic Receptors Affinity of a series of Antagonist Bivalent Ligands 105
16th Camerino-Noordwijkerhout Symposium - An Overview of Receptor Chemistry 105
Structure- Activity Relationships in 1,4-Benzodioxan-related Compounds. 4. Effect of aryl and alkyl Substituents at Position 3 on α-adrenoreceptor blocking activity 105
Design, synthesis and muscarinic activity of deoxamuscarine-related derivatives 105
Alpha(2)-adrenoreceptors profile modulation and high antinociceptive activity of (S)-(-)-2-[1-(biphenyl-2-yloxy)ethyl]-4,5-dihydro-1H-imidazole 104
28th Camerino-Cyprus-Noordwijkerhout Symposium - Trekking through Receptor Chemistry 104
Novel Potent 5-HT1a Agonists Selective over alpha1-Adrenoceptor Subtypes 102
Molecular determinants in the binding of novel 1,4-benzodioxan-related α1D-adrenergic receptor antagonists: a computational study 101
Rational design of novel I1-imidazoline receptor agonists 99
Allyphenyline analogues potentially useful in the management of chronic pain and opioid addiction. 98
Pharmacophore development and 3D-QSAR study of I1 imidazoline binding site ligands 96
Structure-activity relationships in 1,4-benzodioxan-related compounds. 9.From 1,4-benzodioxan to 1,4-dioxane ring as a promising template of novel alpha(1D)-adrenoreceptor antagonists, 5-HT1A full agonists, and cytotoxic agents. 96
Agonists and antagonists targeting the different alpha(2)-adrenoceptor subtypes 95
Structure-Activity Relationships in 1,4-Benzodioxan-Related Compounds. 6. Role of the Dioxane Unit on Selectivity for Alpha1-Adrenoreceptor Subtypes 95
Imidazoline nucleus as a biologically versatile scaffold 95
Design and synthesis of novel imidazoline derivatives potentially targeting dopamine receptors 94
Byciclic dioxolanes as potential antimuscarinic agents 94
Structure-activity relationships in 1,4-benzodioxan-related compounds. 10. Novel alpha1-adrenoreceptor antagonists related to openphendioxan: synthesis, biological evaluation, and alpha1d computational study 93
Rational design of the new antihypertensive I1-receptor ligand 2-(2-Biphenyl-2-yl-1-methyl-ethyl)-4,5-dihydro-1H-imidazole 92
Hybrid molecules from xanomeline and 77-LH-28-1 as potential novel M1 muscarinic agonists 92
Might adrenergic α2C-agonist/α2A-antagonist become a novel therapeutic multitarget tool for morphine chronic treatment of pain? 92
Copresence of 1,4-dioxane and quinuclidine nuclei in the design of novel muscarinic antagonists 91
Totale 13.943
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Categoria #
all - tutte 62.686
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 62.686
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2019/20202.460 0 0 0 588 184 372 324 321 194 191 83 203
2020/20212.447 138 219 179 223 163 150 302 68 205 123 448 229
2021/20221.426 127 330 20 89 109 80 42 98 109 169 87 166
2022/20232.041 240 68 96 297 214 257 14 132 376 121 146 80
2023/20241.431 190 86 95 43 54 132 61 46 144 56 40 484
2024/2025662 190 100 372 0 0 0 0 0 0 0 0 0
Totale 16.076