The imidazoline nucleus linked in position 2 via an oxyethylene bridge to a phenyl ring carrying an ortho substituent of moderate steric bulk provided α2-adrenergic (AR) ligands endowed with significant α2C-agonism/α2A-antagonism. Similar behavior was displayed by cirazoline (12). For their positive morphine analgesia modulation (due to α2C-AR stimulation) and sedation overcoming (due to α2A-AR antagonism), 8 and 11 might be useful as adjuvant agents in the management of pain with morphine.
Might Adrenergic alpha2C-agonists/alpha2A-antagonists become novel therapeutic tools for pain treatment with morphine?
CARDINALETTI, CLAUDIA;MATTIOLI, LAURA;GHELFI, Francesca;DEL BELLO, FABIO;GIANNELLA, Mario;PERFUMI, Marina Cecilia;PIERGENTILI, Alessandro;QUAGLIA, Wilma;PIGINI, Maria
2009-01-01
Abstract
The imidazoline nucleus linked in position 2 via an oxyethylene bridge to a phenyl ring carrying an ortho substituent of moderate steric bulk provided α2-adrenergic (AR) ligands endowed with significant α2C-agonism/α2A-antagonism. Similar behavior was displayed by cirazoline (12). For their positive morphine analgesia modulation (due to α2C-AR stimulation) and sedation overcoming (due to α2A-AR antagonism), 8 and 11 might be useful as adjuvant agents in the management of pain with morphine.File in questo prodotto:
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