Solution-phase synthesis of ICG-001, a beta-turn peptidomimetic molecule inhibitor of beta-catenin-Tcf-mediated transcription

Piergentili, Alessandro; Del Bello, Fabio; Gentili, Francesco; Giannella, Mario; Quaglia, Wilma; Vesprini, Christian; Thomas, R. J.; Robertson, G. M.

The solution-phase synthesis of the beta-turn peptidomimetic ICG-001, a selective inhibitor of Wnt/beta-catenin signalling, which has been found to be important for both initiation and progression of cancers of different tissues and has been exploited as an extremely useful chemogenomic tool, was developed. This route is particularly suitable for the multigram scale preparation of ICG-001.

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Titolo:	Solution-phase synthesis of ICG-001, a beta-turn peptidomimetic molecule inhibitor of beta-catenin-Tcf-mediated transcription
Autori:	PIERGENTILI, Alessandro DEL BELLO, Fabio GENTILI, Francesco GIANNELLA, Mario QUAGLIA, Wilma VESPRINI, Christian THOMAS R. J. ROBERTSON G. M. mostra contributor esterni nascondi contributor esterni
Data di pubblicazione:	2007
Rivista:	TETRAHEDRON
Abstract:	The solution-phase synthesis of the beta-turn peptidomimetic ICG-001, a selective inhibitor of Wnt/beta-catenin signalling, which has been found to be important for both initiation and progression of cancers of different tissues and has been exploited as an extremely useful chemogenomic tool, was developed. This route is particularly suitable for the multigram scale preparation of ICG-001.
Handle:	http://hdl.handle.net/11581/113647
Appare nelle tipologie:	Articolo

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