Opioid addiction is often characterized as a chronic relapsing condition due to the severe somatic and behavioral signs, associated with depressive disorders, triggered by opiate withdrawal. Since prolonged abstinence remains a major challenge, our interest has been addressed to such objective. Exploring multitarget interactions, the present investigation suggests that 3 or its (S)-enantiomer and 4, endowed with effective α2C-AR agonism/α2A-AR antagonism/5-HT1A-R agonism, or 7 and 9−11 producing efficacious α2C-AR agonism/α2A-AR antagonism/I2−IBS interaction might represent novel multifunctional tools potentially useful for reducing withdrawal syndrome and associated depression. Such agents, lacking in sedative side effects due to their α2A-AR antagonism, might afford an improvement over current therapies with clonidine-like drugs

Exploring multitarget interactions to reduce opiate withdrawal syndrome and psychiatric comorbidity

DEL BELLO, FABIO;GIANNELLA, Mario;MATTIOLI, LAURA;PIERGENTILI, Alessandro;QUAGLIA, Wilma;PIGINI, Maria
2013-01-01

Abstract

Opioid addiction is often characterized as a chronic relapsing condition due to the severe somatic and behavioral signs, associated with depressive disorders, triggered by opiate withdrawal. Since prolonged abstinence remains a major challenge, our interest has been addressed to such objective. Exploring multitarget interactions, the present investigation suggests that 3 or its (S)-enantiomer and 4, endowed with effective α2C-AR agonism/α2A-AR antagonism/5-HT1A-R agonism, or 7 and 9−11 producing efficacious α2C-AR agonism/α2A-AR antagonism/I2−IBS interaction might represent novel multifunctional tools potentially useful for reducing withdrawal syndrome and associated depression. Such agents, lacking in sedative side effects due to their α2A-AR antagonism, might afford an improvement over current therapies with clonidine-like drugs
2013
262
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11581/311382
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