2-(2-Phenylcyclopropyl)imidazolines: Reversed Enantioselective Interaction at I1 and I2 Imidazoline Receptors

Quaglia, Wilma; Bousquet, P.; Pigini, Maria; Carotti, A.; Carrieri, A.; Dontenwill, M.; Gentili, Francesco; Giannella, Mario; Maranca, F.; Piergentili, Alessandro; Brasili, L.

We have shown that the imidazoline I1 and I2 receptor binding sites have stereospecific requirements, the two subtypes showing a reversal of enatioselectivity, which may offer leads to the development of selective imidazoline receptor ligands. The couple of imidazoline enantiomers (1R,2R)-(-)-4b and (1S,2S)-(+)-4b reported herein, together with other properly designed chiral ligands, may be considered as valid tools for a more extensive eudismic analysis aimed at a necessary subtyping of the I receptors. Work along this line is in progress.

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Titolo:	2-(2-Phenylcyclopropyl)imidazolines: Reversed Enantioselective Interaction at I1 and I2 Imidazoline Receptors
Autori:	QUAGLIA, Wilma BOUSQUET P. PIGINI, Maria CAROTTI A. CARRIERI A. DONTENWILL M. GENTILI, Francesco GIANNELLA, Mario MARANCA F. PIERGENTILI, Alessandro BRASILI L. mostra contributor esterni nascondi contributor esterni
Data di pubblicazione:	1999
Rivista:	JOURNAL OF MEDICINAL CHEMISTRY
Abstract:	We have shown that the imidazoline I1 and I2 receptor binding sites have stereospecific requirements, the two subtypes showing a reversal of enatioselectivity, which may offer leads to the development of selective imidazoline receptor ligands. The couple of imidazoline enantiomers (1R,2R)-(-)-4b and (1S,2S)-(+)-4b reported herein, together with other properly designed chiral ligands, may be considered as valid tools for a more extensive eudismic analysis aimed at a necessary subtyping of the I receptors. Work along this line is in progress.
Handle:	http://hdl.handle.net/11581/114156
Appare nelle tipologie:	Articolo

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