We have shown that the imidazoline I1 and I2 receptor binding sites have stereospecific requirements, the two subtypes showing a reversal of enatioselectivity, which may offer leads to the development of selective imidazoline receptor ligands. The couple of imidazoline enantiomers (1R,2R)-(-)-4b and (1S,2S)-(+)-4b reported herein, together with other properly designed chiral ligands, may be considered as valid tools for a more extensive eudismic analysis aimed at a necessary subtyping of the I receptors. Work along this line is in progress.

2-(2-Phenylcyclopropyl)imidazolines: Reversed Enantioselective Interaction at I1 and I2 Imidazoline Receptors

QUAGLIA, Wilma;PIGINI, Maria;GENTILI, Francesco;GIANNELLA, Mario;PIERGENTILI, Alessandro;
1999-01-01

Abstract

We have shown that the imidazoline I1 and I2 receptor binding sites have stereospecific requirements, the two subtypes showing a reversal of enatioselectivity, which may offer leads to the development of selective imidazoline receptor ligands. The couple of imidazoline enantiomers (1R,2R)-(-)-4b and (1S,2S)-(+)-4b reported herein, together with other properly designed chiral ligands, may be considered as valid tools for a more extensive eudismic analysis aimed at a necessary subtyping of the I receptors. Work along this line is in progress.
1999
262
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11581/114156
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