PIGINI, Maria
 Distribuzione geografica
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Continente #
NA - Nord America 7.109
EU - Europa 3.016
AS - Asia 1.622
Continente sconosciuto - Info sul continente non disponibili 39
SA - Sud America 23
OC - Oceania 9
AF - Africa 4
Totale 11.822
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Nazione #
US - Stati Uniti d'America 6.859
CN - Cina 1.269
DE - Germania 848
IT - Italia 576
UA - Ucraina 300
SE - Svezia 263
CA - Canada 246
GB - Regno Unito 213
SG - Singapore 205
FI - Finlandia 197
PL - Polonia 165
FR - Francia 130
RU - Federazione Russa 119
TR - Turchia 83
IE - Irlanda 65
CZ - Repubblica Ceca 51
BE - Belgio 40
EU - Europa 35
IR - Iran 18
BR - Brasile 15
IN - India 14
NL - Olanda 13
RO - Romania 11
AU - Australia 9
HK - Hong Kong 7
VN - Vietnam 7
LT - Lituania 5
A2 - ???statistics.table.value.countryCode.A2??? 4
ID - Indonesia 4
RS - Serbia 4
CH - Svizzera 3
CL - Cile 3
ES - Italia 3
KH - Cambogia 3
AR - Argentina 2
BG - Bulgaria 2
DK - Danimarca 2
HU - Ungheria 2
IL - Israele 2
MX - Messico 2
ZA - Sudafrica 2
AE - Emirati Arabi Uniti 1
AZ - Azerbaigian 1
BD - Bangladesh 1
BY - Bielorussia 1
CO - Colombia 1
DZ - Algeria 1
GE - Georgia 1
GR - Grecia 1
IQ - Iraq 1
JM - Giamaica 1
JP - Giappone 1
KG - Kirghizistan 1
LV - Lettonia 1
MA - Marocco 1
MN - Mongolia 1
MY - Malesia 1
PA - Panama 1
PE - Perù 1
PT - Portogallo 1
TH - Thailandia 1
VE - Venezuela 1
Totale 11.822
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Città #
Woodbridge 773
Jacksonville 745
Chandler 606
Fairfield 574
Ann Arbor 503
Wilmington 382
Houston 367
Ashburn 364
Boardman 286
Nanjing 258
Seattle 227
Cambridge 187
Toronto 176
Dearborn 169
Singapore 143
Düsseldorf 135
Kraków 123
San Mateo 117
Beijing 116
Nanchang 98
Helsinki 95
Lawrence 93
Princeton 93
Columbus 86
Ogden 71
Istanbul 70
Lachine 67
Dublin 65
Shenyang 59
Kunming 57
Shanghai 57
Camerino 56
Tianjin 52
London 51
Guangzhou 48
Venezia 44
Los Angeles 43
Moscow 43
Warsaw 42
Jiaxing 41
Brno 40
Brussels 40
Changsha 40
New York 38
Hebei 37
Jinan 33
Nürnberg 32
Milan 30
Hangzhou 29
San Diego 28
Venice 26
Philadelphia 25
Zhengzhou 25
Falls Church 24
Washington 23
Munich 20
Wuhan 20
Orange 19
Redwood City 19
Taizhou 17
Fuzhou 16
Leawood 15
Ningbo 15
Chicago 14
Monmouth Junction 14
Old Bridge 14
Verona 14
Hefei 13
Kocaeli 12
Bremen 11
Centro 11
Changchun 11
Olomouc 11
Perugia 11
Ardabil 10
Auburn Hills 10
Yiwu 10
Buffalo 9
Lanzhou 9
Augusta 8
Baotou 8
Espoo 8
Hanover 8
Indiana 8
Mountain View 8
Nantong 8
Tulsa 8
Horia 7
Tappahannock 7
Berlin 6
Buti 6
Detroit 6
Dronten 6
Nuremberg 6
Santa Clara 6
Strasbourg 6
West Jordan 6
Chengdu 5
Frankfurt am Main 5
Heze 5
Totale 8.518
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Nome #
1,4-DIOXANE NUCLEUS AS A SUITABLE SCAFFOLD FOR NOVEL D2-LIKE RECEPTOR LIGANDS 269
1,4-Dioxane, a Suitable Scaffold for the Development of Novel M3 Muscarinic Receptor Antagonists 266
The Versatile 2-Substituted Imidazoline Nucleus as a Structural Motif of Ligands Directed to the Serotonin 5-HT1A Receptor 250
Antagonism/Agonism modulation to build novel antihypertensives selectively triggering i1-imidazoline receptor activation 247
Hyperphagic effect of novel compounds with high affinity for imidazoline I2 binding sites 242
Combined Interactions with I1-, I2-Imidazoline Binding Sites and α2-Adrenoceptors To Manage Opioid Addiction 211
A Novel Class of Dopamine D4 Receptor Ligands Bearing an Imidazoline Nucleus 210
1'-Benzyl-3,4-dihydrospiro[2H-1-benzothiopyran-2,4'-piperidine] (Spipethiane), a potent and highly selective sigma1 lingand 200
1,4-Dioxane ring as a promising template of novel 5-HT1A full agonists 196
Novel ligands rationally designed for characterizing I2-imidazoline binding sites nature and functions 189
Investigation of allyphenyline efficacy in the treatment of alcohol withdrawal symptoms 175
Discovery of Highly Selective Imidazoline Receptor Ligands 170
Structure-activity relationships in 1,4-benzodioxan-related compounds. Investigation on the role of the dehydrodioxane ring on alpha1-adrenoreceptor blocking activity 166
Biological profile and bioavailability of imidazoline compounds on morphine tolerance modulation 165
2-(2-Phenylcyclopropyl)imidazolines: Reversed Enantioselective Interaction at I1 and I2 Imidazoline Receptors 163
31st Camerino-Cyprus-Noordwijkerhout Symposium - Receptor Chemistry Skyline 163
Favourable involvement of α2A-adrenoreceptor antagonism in the I₂-imidazoline binding sites-mediated morphine analgesia enhancement. 159
Novel Imidazoline Compounds as Partial or Full Agonists of D2-Like Dopamine Receptors Inspired by I2-Imidazoline Binding Sites Ligand 2-BFI 151
Structure−Activity Relationships in 1,4-Benzodioxan-Related Compounds. 11.1 Reversed Enantioselectivity of 1,4-Dioxane Derivatives in α1‑Adrenergic and 5‑HT1A Receptor Binding Sites Recognition 150
Properly substituted 1,4-dioxane nucleus favours the selective M3 muscarinic receptor activation 148
Novel Highly Potent and Selective σ1 Receptor Antagonists Related to Spipethiane 148
“Pharmacological Characterization of Muscarinic Receptor Subtypes in Rabbit Isolated Tissue Preparations” 147
Imidazoline binding sites (IBS) profile modulation: Key role of the bridge in determining I1-IBS or I2-IBS selectivity within a series of 2-phenoxymethylimidazoline analogues 146
alpha(2)-Adrenoreceptors profile modulation. 2. Biphenyline analogues as tools for selective activation of the alpha2C-subtype 145
Use of frozen sections for the pharmacological characterization of compounds active on neurotransmitter receptors 145
Binding of nicotine and homoazanicotine analogues at neuronal nicotinic acetylcholinergic (nACh) receptors 145
Homoazanicotine: A structure-affinity study for nicotinic acetylcholine (nACh) receptor binding 144
Muscarinic Thioligands with Cyclopentane Nucleus 143
Muscarinic subtypes profile modulation within a series of new antagonists, bridged bicyclic derivatives of 2,2-diphenyl-[1,3]-dioxolan-4-ylmethyl-dimethylamine 142
Chain-lengthened and imidazoline analogues of nicotine 141
Potent muscarinic antagonists bearing 1,4-dioxane scaffold 141
Deoxamuscaroneoxime Devatives as useful Muscarinic Aginist to Explore the Muscarinic Subsite: Demox, Amodulator of Orthosteric and Allosteric Site at Cardiac Muscarinic M2 Receptors. 140
3-Phenyl analogues of 2-[[[2-(2,6-Dimethoxyphenoxyethyllamino]methyl]-1,4-benzodioxan (WB 4101) as highly selective alpha1-adrenoreceptor antagonists1 137
Synthesis and muscarinic properties of (1S*,3R*,5R*)-trimethyl(1-methyl-6-oxabicyclo[3.1.0]hex-3-yl)methyl ammonium iodide 137
Low doses of allyphenyline and cyclomethyline, effective against morphine dependence, elicit an antidepressant-like effect 136
14th Camerino-Noordwijkerhout Symposium - Ongoing Progress in Receptor Chemistry 135
Novel 1,4-dioxane derivatives as NMDA receptor channel blockers 133
Exploring multitarget interactions to reduce opiate withdrawal syndrome and psychiatric comorbidity 131
Synthesis and Structure-Activity Relationship Studies in a Series of 2-Substituted 1,3-Dioxolanes Modified at the Cationic Head. 131
Structure-activity relationships in 1,4-benzodioxan-related compounds. 7. Selectivity of 4-phenylchroman analogues for alpha(1)-adrenoreceptor subtypes 128
Dual Alpha2C/5HT1A Receptor Agonist Allyphenyline Induces Gastroprotection and Inhibits Fundic and Colonic Contractility 128
Synthesis, Absolute Configuration, and Biological Profile of the Enantiomers of trans-[2-(2,6-Dimethoxypheoxy)ethyl] [(3-p-tolyl-2,3-dihydro-1,4-benzodioxin-2-yl)methyl]amine (Mephendioxan), a Potent Competitive alpha 1A-Adrenoreceptor Antagonist 126
I1 imidazoline receptor-mediated effects on apoptotic processes in PC12 cells. 124
Might Adrenergic alpha2C-agonists/alpha2A-antagonists become novel therapeutic tools for pain treatment with morphine? 122
Alpha(2)-Adrenoreceptors Profile Modulation. 3. (R)-(+)-m-Nitrobiphenyline, a New Efficient and alpha(2C)-Subtype Selective Agonist. 119
Imidazoline receptors: Qualitative structure-activity relationships and discovery of tracizoline and benazoline. Two ligands with high affinity and unprecedented selectivity 119
Ligand binding to I2 imidazoline receptor: the role of lipophilicity in quantitative structure-activity relationship models 116
Fruitful Adrenergic alpha(2C)-Agonism/alpha(2A)-Antagonism Combination to Prevent and Contrast Morphine Tolerance and Dependence 115
Structure-activity relationships in 1,4-benzodioxan-related compounds. 8.(1) {2-[2-(4 chlorobenzyloxy)phenoxy]ethyl}-[2-(2,6-dimethoxyphenoxy)ethyl]amine (clopenphendioxan) as a tool to highlight the involvement of alpha1D- and alpha1B-adrenoreceptor subtypes in the regulation of human PC-3 prostate cancer cell apoptosis and proliferation 113
From benzodioxane to 1,4-dioxane scaffold in the design of 5-HT1A serotoninergic full agonists from α1-adrenergic antagonists 111
Allyphenyline analogues potentially useful in the management of chronic pain and opioid addiction. 111
31st Camerino-Cyprus-Noordwijkerhout Symposium - Receptor Chemistry Skyline 111
Design, synthesis and muscarinic activity of deoxamuscarine-related derivatives 111
alpha(2)-adrenoreceptors profile modulation. 4. From antagonist, to agonist behavior 111
TESTING D2-LIKE RECEPTOR AFFINITY AND SELECTIVITY WITH NOVEL IMIDAZOLINE DERIVATIVES 110
28th Camerino-Cyprus-Noordwijkerhout Symposium - Trekking through Receptor Chemistry 109
16th Camerino-Noordwijkerhout Symposium - An Overview of Receptor Chemistry 109
Alpha(2)-adrenoreceptors profile modulation and high antinociceptive activity of (S)-(-)-2-[1-(biphenyl-2-yloxy)ethyl]-4,5-dihydro-1H-imidazole 108
Novel Dopamine Receptor Ligands Bearing Imidazoline Nucleus. 108
Structure- Activity Relationships in 1,4-Benzodioxan-related Compounds. 4. Effect of aryl and alkyl Substituents at Position 3 on α-adrenoreceptor blocking activity 107
Rational design of novel I1-imidazoline receptor agonists 104
Age-related Changes in the Density of Muscarinic Cholinergic M1 and M2 Receptor Subtypes in Pyramidal Neurons or the rat Hippocampus 104
Molecular determinants in the binding of novel 1,4-benzodioxan-related α1D-adrenergic receptor antagonists: a computational study 103
Effects of allyphenyline on chronic alcohol intoxication model 102
Imidazoline nucleus as a biologically versatile scaffold 101
Pharmacophore development and 3D-QSAR study of I1 imidazoline binding site ligands 101
Agonists and antagonists targeting the different alpha(2)-adrenoceptor subtypes 100
NOVEL BIVALENT LIGANDS OF XANOMELINE AND 77-LH-28-1 AS POTENTIAL M1 MUSCARINIC AGONISTS 98
Structure-activity relationships in 1,4-benzodioxan-related compounds. 9.From 1,4-benzodioxan to 1,4-dioxane ring as a promising template of novel alpha(1D)-adrenoreceptor antagonists, 5-HT1A full agonists, and cytotoxic agents. 98
Structure-Activity Relationships in 1,4-Benzodioxan-Related Compounds. 6. Role of the Dioxane Unit on Selectivity for Alpha1-Adrenoreceptor Subtypes 97
Byciclic dioxolanes as potential antimuscarinic agents 97
Might adrenergic α2C-agonist/α2A-antagonist become a novel therapeutic multitarget tool for morphine chronic treatment of pain? 97
Hybrid molecules from xanomeline and 77-LH-28-1 as potential novel M1 muscarinic agonists 96
Structure-activity relationships in 1,4-benzodioxan-related compounds. 10. Novel alpha1-adrenoreceptor antagonists related to openphendioxan: synthesis, biological evaluation, and alpha1d computational study 95
Copresence of 1,4-dioxane and quinuclidine nuclei in the design of novel muscarinic antagonists 94
Rational design of new alpha(2)-adrenoreceptor agonists 94
Separation of alpha-adrenergic and imidazoline/guanidinium receptive sites (IGRS) activity in a series of imidazoline analogues of cirazoline 94
Adrenoceptors as targets in drug discovery: Medicinal chemistry and therapeutical potential 93
Enantioselective interactions to improve adrenergic α2C-agonism/α2A-antagonism 93
Alpha 1-adrenoreceptor antagonists bearing a quinazoline or a benzodioxane moiety 91
MORPHINE TOLERANCE MODULATION INDUCED BY alpha2-ADRENERGIC OR/AND I2 IMIDAZOLINE BINDING SITES LIGANDS 91
Enantiomers of 6,6-diphenyl-1,4-dioxane derivatives to highlight stereochemical requirements for selective alpha1D-AR and 5- HT1A receptor recognition 91
Structure- Activity Relationships in 1,4-Benzodioxan-related Compounds. 5. Effects of Modification of the side chain on alpha-adrenoreceptor blocking Activity 88
Might the observed alpha2A-adrenoreceptor agonism or antagonism of allyphenyline analogues be ascribed to different molecular conformations? 88
Structure-activity relationship at alpha-adrenergic receptors within a series of imidazoline analogues of cirazoline 88
Binding of Tracizolines to the Imidazoline Receptor. Role of Lipophilicity in Quantitative Structure-Activity Relationship Models. 88
Structural motives of imidazoline molecules favouring the serotonin 5-HT1A receptor activation 85
Coupling of I-1 Imidazoline Receptors to the cAMP Pathway: Studies with a Highly Selective Ligand, Benazoline 83
Alpha2C-adrenoceptor modulators: a patent review 81
Novel α1-adrenoreceptor antagonists related to openphendioxan: biological evaluation and α1d computational study 80
Synthesis and alpha-blocking activity of some analogues of idazoxan 80
Synergic stimulation of serotonin 5-HT1A receptor and α2-adrenoceptors for neuropathic pain relief: Preclinical effects of 2-substituted imidazoline derivatives 78
Novel muscarinic antagonists designed on the 1,4-dioxane scaffold 76
Totale 12.022
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Categoria #
all - tutte 46.272
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 46.272
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2019/2020936 0 0 0 0 0 0 246 233 125 142 51 139
2020/20211.440 79 119 81 137 83 83 159 20 132 60 322 165
2021/20221.016 88 241 15 74 66 61 25 75 74 118 63 116
2022/20231.528 176 54 66 238 172 204 10 102 284 87 85 50
2023/2024967 156 61 66 28 41 85 34 15 100 37 23 321
2024/2025817 118 78 250 136 74 156 5 0 0 0 0 0
Totale 12.022