PIGINI, Maria
 Distribuzione geografica
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Continente #
NA - Nord America 9.211
EU - Europa 4.228
AS - Asia 3.100
SA - Sud America 379
AF - Africa 48
Continente sconosciuto - Info sul continente non disponibili 39
OC - Oceania 19
Totale 17.024
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Nazione #
US - Stati Uniti d'America 8.889
CN - Cina 1.638
RU - Federazione Russa 1.020
DE - Germania 923
SG - Singapore 791
IT - Italia 593
BR - Brasile 329
UA - Ucraina 307
CA - Canada 280
SE - Svezia 274
GB - Regno Unito 265
FI - Finlandia 240
HK - Hong Kong 225
PL - Polonia 191
FR - Francia 149
TR - Turchia 116
KR - Corea 97
VN - Vietnam 68
IE - Irlanda 66
CZ - Repubblica Ceca 51
IN - India 49
BE - Belgio 44
EU - Europa 35
MX - Messico 29
ES - Italia 22
IR - Iran 22
ZA - Sudafrica 22
JP - Giappone 21
AR - Argentina 20
NL - Olanda 18
AU - Australia 17
LT - Lituania 17
EC - Ecuador 14
BD - Bangladesh 12
RO - Romania 12
EG - Egitto 9
IQ - Iraq 9
ID - Indonesia 8
MA - Marocco 7
AT - Austria 6
AE - Emirati Arabi Uniti 5
RS - Serbia 5
A2 - ???statistics.table.value.countryCode.A2??? 4
CH - Svizzera 4
CO - Colombia 4
DZ - Algeria 4
JO - Giordania 4
PE - Perù 4
AL - Albania 3
AZ - Azerbaigian 3
BG - Bulgaria 3
CL - Cile 3
GR - Grecia 3
HU - Ungheria 3
IL - Israele 3
JM - Giamaica 3
KH - Cambogia 3
NP - Nepal 3
PA - Panama 3
PH - Filippine 3
SA - Arabia Saudita 3
BY - Bielorussia 2
DK - Danimarca 2
KE - Kenya 2
KG - Kirghizistan 2
KZ - Kazakistan 2
NI - Nicaragua 2
NZ - Nuova Zelanda 2
PK - Pakistan 2
PY - Paraguay 2
QA - Qatar 2
SN - Senegal 2
VE - Venezuela 2
AD - Andorra 1
BO - Bolivia 1
BZ - Belize 1
DO - Repubblica Dominicana 1
GE - Georgia 1
GH - Ghana 1
GT - Guatemala 1
HN - Honduras 1
HR - Croazia 1
IS - Islanda 1
LB - Libano 1
LC - Santa Lucia 1
LK - Sri Lanka 1
LV - Lettonia 1
MN - Mongolia 1
MU - Mauritius 1
MY - Malesia 1
PS - Palestinian Territory 1
PT - Portogallo 1
TH - Thailandia 1
TW - Taiwan 1
UZ - Uzbekistan 1
Totale 17.024
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Città #
Dallas 960
Woodbridge 773
Jacksonville 745
Chandler 606
Ashburn 582
Fairfield 574
Ann Arbor 503
Wilmington 383
Houston 374
Singapore 363
Boardman 286
Nanjing 258
Beijing 257
Seattle 232
Hong Kong 219
Cambridge 188
Toronto 182
Dearborn 169
Los Angeles 146
Düsseldorf 139
Kraków 123
San Mateo 117
The Dalles 113
New York 111
Columbus 98
Nanchang 98
Helsinki 95
Seoul 95
Lawrence 93
Princeton 93
Tongling 93
Istanbul 86
Munich 74
Buffalo 72
Ogden 71
Lachine 67
Dublin 66
Moscow 66
Warsaw 64
Shanghai 59
Shenyang 59
London 58
Camerino 57
Kunming 57
Tianjin 54
Guangzhou 49
Brussels 44
Venezia 44
Turku 43
Changsha 41
Jiaxing 41
Brno 40
Milan 40
São Paulo 39
Hebei 37
Chicago 35
Jinan 33
Hangzhou 32
Nürnberg 32
Santa Clara 32
San Diego 29
Philadelphia 26
Venice 26
Zhengzhou 26
Washington 25
Denver 24
Falls Church 24
Ho Chi Minh City 23
Poplar 23
Wuhan 20
Orange 19
Redwood City 19
Tokyo 18
Brooklyn 17
Chennai 17
Orem 17
Taizhou 17
Boston 16
Fuzhou 16
Hanoi 16
Frankfurt am Main 15
Johannesburg 15
Leawood 15
Ningbo 15
Monmouth Junction 14
Old Bridge 14
Phoenix 14
Verona 14
Council Bluffs 13
Hefei 13
Stockholm 13
Ankara 12
Kocaeli 12
Montreal 12
Augusta 11
Bremen 11
Centro 11
Changchun 11
Olomouc 11
Perugia 11
Totale 11.235
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Nome #
1,4-Dioxane, a Suitable Scaffold for the Development of Novel M3 Muscarinic Receptor Antagonists 587
1,4-DIOXANE NUCLEUS AS A SUITABLE SCAFFOLD FOR NOVEL D2-LIKE RECEPTOR LIGANDS 582
1'-Benzyl-3,4-dihydrospiro[2H-1-benzothiopyran-2,4'-piperidine] (Spipethiane), a potent and highly selective sigma1 lingand 518
1,4-Dioxane ring as a promising template of novel 5-HT1A full agonists 517
The Versatile 2-Substituted Imidazoline Nucleus as a Structural Motif of Ligands Directed to the Serotonin 5-HT1A Receptor 308
Antagonism/Agonism modulation to build novel antihypertensives selectively triggering i1-imidazoline receptor activation 304
Hyperphagic effect of novel compounds with high affinity for imidazoline I2 binding sites 288
A Novel Class of Dopamine D4 Receptor Ligands Bearing an Imidazoline Nucleus 274
Combined Interactions with I1-, I2-Imidazoline Binding Sites and α2-Adrenoceptors To Manage Opioid Addiction 262
Novel ligands rationally designed for characterizing I2-imidazoline binding sites nature and functions 244
31st Camerino-Cyprus-Noordwijkerhout Symposium - Receptor Chemistry Skyline 240
Investigation of allyphenyline efficacy in the treatment of alcohol withdrawal symptoms 233
2-(2-Phenylcyclopropyl)imidazolines: Reversed Enantioselective Interaction at I1 and I2 Imidazoline Receptors 232
Favourable involvement of α2A-adrenoreceptor antagonism in the I₂-imidazoline binding sites-mediated morphine analgesia enhancement. 228
Biological profile and bioavailability of imidazoline compounds on morphine tolerance modulation 218
alpha(2)-Adrenoreceptors profile modulation. 2. Biphenyline analogues as tools for selective activation of the alpha2C-subtype 217
Discovery of Highly Selective Imidazoline Receptor Ligands 211
14th Camerino-Noordwijkerhout Symposium - Ongoing Progress in Receptor Chemistry 206
Imidazoline binding sites (IBS) profile modulation: Key role of the bridge in determining I1-IBS or I2-IBS selectivity within a series of 2-phenoxymethylimidazoline analogues 206
Structure-activity relationships in 1,4-benzodioxan-related compounds. Investigation on the role of the dehydrodioxane ring on alpha1-adrenoreceptor blocking activity 200
Novel 1,4-dioxane derivatives as NMDA receptor channel blockers 192
Structure-activity relationships in 1,4-benzodioxan-related compounds. 7. Selectivity of 4-phenylchroman analogues for alpha(1)-adrenoreceptor subtypes 191
Deoxamuscaroneoxime Devatives as useful Muscarinic Aginist to Explore the Muscarinic Subsite: Demox, Amodulator of Orthosteric and Allosteric Site at Cardiac Muscarinic M2 Receptors. 190
Novel Highly Potent and Selective σ1 Receptor Antagonists Related to Spipethiane 190
3-Phenyl analogues of 2-[[[2-(2,6-Dimethoxyphenoxyethyllamino]methyl]-1,4-benzodioxan (WB 4101) as highly selective alpha1-adrenoreceptor antagonists1 189
Novel Imidazoline Compounds as Partial or Full Agonists of D2-Like Dopamine Receptors Inspired by I2-Imidazoline Binding Sites Ligand 2-BFI 188
Muscarinic subtypes profile modulation within a series of new antagonists, bridged bicyclic derivatives of 2,2-diphenyl-[1,3]-dioxolan-4-ylmethyl-dimethylamine 186
31st Camerino-Cyprus-Noordwijkerhout Symposium - Receptor Chemistry Skyline 183
Synthesis and muscarinic properties of (1S*,3R*,5R*)-trimethyl(1-methyl-6-oxabicyclo[3.1.0]hex-3-yl)methyl ammonium iodide 183
Design, synthesis and muscarinic activity of deoxamuscarine-related derivatives 183
Homoazanicotine: A structure-affinity study for nicotinic acetylcholine (nACh) receptor binding 182
Use of frozen sections for the pharmacological characterization of compounds active on neurotransmitter receptors 182
Low doses of allyphenyline and cyclomethyline, effective against morphine dependence, elicit an antidepressant-like effect 181
Structure−Activity Relationships in 1,4-Benzodioxan-Related Compounds. 11.1 Reversed Enantioselectivity of 1,4-Dioxane Derivatives in α1‑Adrenergic and 5‑HT1A Receptor Binding Sites Recognition 179
28th Camerino-Cyprus-Noordwijkerhout Symposium - Trekking through Receptor Chemistry 177
Properly substituted 1,4-dioxane nucleus favours the selective M3 muscarinic receptor activation 176
Potent muscarinic antagonists bearing 1,4-dioxane scaffold 176
“Pharmacological Characterization of Muscarinic Receptor Subtypes in Rabbit Isolated Tissue Preparations” 175
Binding of nicotine and homoazanicotine analogues at neuronal nicotinic acetylcholinergic (nACh) receptors 174
Alpha(2)-Adrenoreceptors Profile Modulation. 3. (R)-(+)-m-Nitrobiphenyline, a New Efficient and alpha(2C)-Subtype Selective Agonist. 172
16th Camerino-Noordwijkerhout Symposium - An Overview of Receptor Chemistry 170
Exploring multitarget interactions to reduce opiate withdrawal syndrome and psychiatric comorbidity 170
Synthesis and Structure-Activity Relationship Studies in a Series of 2-Substituted 1,3-Dioxolanes Modified at the Cationic Head. 170
Might Adrenergic alpha2C-agonists/alpha2A-antagonists become novel therapeutic tools for pain treatment with morphine? 170
Muscarinic Thioligands with Cyclopentane Nucleus 168
Allyphenyline analogues potentially useful in the management of chronic pain and opioid addiction. 167
Chain-lengthened and imidazoline analogues of nicotine 165
Synthesis, Absolute Configuration, and Biological Profile of the Enantiomers of trans-[2-(2,6-Dimethoxypheoxy)ethyl] [(3-p-tolyl-2,3-dihydro-1,4-benzodioxin-2-yl)methyl]amine (Mephendioxan), a Potent Competitive alpha 1A-Adrenoreceptor Antagonist 164
Alpha(2)-adrenoreceptors profile modulation and high antinociceptive activity of (S)-(-)-2-[1-(biphenyl-2-yloxy)ethyl]-4,5-dihydro-1H-imidazole 164
Dual Alpha2C/5HT1A Receptor Agonist Allyphenyline Induces Gastroprotection and Inhibits Fundic and Colonic Contractility 161
Fruitful Adrenergic alpha(2C)-Agonism/alpha(2A)-Antagonism Combination to Prevent and Contrast Morphine Tolerance and Dependence 160
Novel Dopamine Receptor Ligands Bearing Imidazoline Nucleus. 158
Ligand binding to I2 imidazoline receptor: the role of lipophilicity in quantitative structure-activity relationship models 158
Structure-activity relationships in 1,4-benzodioxan-related compounds. 8.(1) {2-[2-(4 chlorobenzyloxy)phenoxy]ethyl}-[2-(2,6-dimethoxyphenoxy)ethyl]amine (clopenphendioxan) as a tool to highlight the involvement of alpha1D- and alpha1B-adrenoreceptor subtypes in the regulation of human PC-3 prostate cancer cell apoptosis and proliferation 158
Age-related Changes in the Density of Muscarinic Cholinergic M1 and M2 Receptor Subtypes in Pyramidal Neurons or the rat Hippocampus 156
alpha(2)-adrenoreceptors profile modulation. 4. From antagonist, to agonist behavior 155
TESTING D2-LIKE RECEPTOR AFFINITY AND SELECTIVITY WITH NOVEL IMIDAZOLINE DERIVATIVES 154
Enantioselective interactions to improve adrenergic α2C-agonism/α2A-antagonism 153
NOVEL BIVALENT LIGANDS OF XANOMELINE AND 77-LH-28-1 AS POTENTIAL M1 MUSCARINIC AGONISTS 153
Agonists and antagonists targeting the different alpha(2)-adrenoceptor subtypes 152
Imidazoline receptors: Qualitative structure-activity relationships and discovery of tracizoline and benazoline. Two ligands with high affinity and unprecedented selectivity 152
Rational design of novel I1-imidazoline receptor agonists 150
Might adrenergic α2C-agonist/α2A-antagonist become a novel therapeutic multitarget tool for morphine chronic treatment of pain? 150
I1 imidazoline receptor-mediated effects on apoptotic processes in PC12 cells. 149
From benzodioxane to 1,4-dioxane scaffold in the design of 5-HT1A serotoninergic full agonists from α1-adrenergic antagonists 148
Pharmacophore development and 3D-QSAR study of I1 imidazoline binding site ligands 146
Alpha 1-adrenoreceptor antagonists bearing a quinazoline or a benzodioxane moiety 145
Adrenoceptors as targets in drug discovery: Medicinal chemistry and therapeutical potential 143
Byciclic dioxolanes as potential antimuscarinic agents 143
Structure-activity relationships in 1,4-benzodioxan-related compounds. 9.From 1,4-benzodioxan to 1,4-dioxane ring as a promising template of novel alpha(1D)-adrenoreceptor antagonists, 5-HT1A full agonists, and cytotoxic agents. 142
Structure- Activity Relationships in 1,4-Benzodioxan-related Compounds. 4. Effect of aryl and alkyl Substituents at Position 3 on α-adrenoreceptor blocking activity 141
Structure-activity relationship at alpha-adrenergic receptors within a series of imidazoline analogues of cirazoline 140
Rational design of new alpha(2)-adrenoreceptor agonists 140
Imidazoline nucleus as a biologically versatile scaffold 139
Effects of allyphenyline on chronic alcohol intoxication model 138
MORPHINE TOLERANCE MODULATION INDUCED BY alpha2-ADRENERGIC OR/AND I2 IMIDAZOLINE BINDING SITES LIGANDS 136
Hybrid molecules from xanomeline and 77-LH-28-1 as potential novel M1 muscarinic agonists 134
Binding of Tracizolines to the Imidazoline Receptor. Role of Lipophilicity in Quantitative Structure-Activity Relationship Models. 134
Structure-Activity Relationships in 1,4-Benzodioxan-Related Compounds. 6. Role of the Dioxane Unit on Selectivity for Alpha1-Adrenoreceptor Subtypes 128
Molecular determinants in the binding of novel 1,4-benzodioxan-related α1D-adrenergic receptor antagonists: a computational study 127
Separation of alpha-adrenergic and imidazoline/guanidinium receptive sites (IGRS) activity in a series of imidazoline analogues of cirazoline 123
Copresence of 1,4-dioxane and quinuclidine nuclei in the design of novel muscarinic antagonists 121
Structure-activity relationships in 1,4-benzodioxan-related compounds. 10. Novel alpha1-adrenoreceptor antagonists related to openphendioxan: synthesis, biological evaluation, and alpha1d computational study 119
Enantiomers of 6,6-diphenyl-1,4-dioxane derivatives to highlight stereochemical requirements for selective alpha1D-AR and 5- HT1A receptor recognition 118
Structure- Activity Relationships in 1,4-Benzodioxan-related Compounds. 5. Effects of Modification of the side chain on alpha-adrenoreceptor blocking Activity 116
Might the observed alpha2A-adrenoreceptor agonism or antagonism of allyphenyline analogues be ascribed to different molecular conformations? 115
Structural motives of imidazoline molecules favouring the serotonin 5-HT1A receptor activation 113
Synthesis and alpha-blocking activity of some analogues of idazoxan 108
Novel α1-adrenoreceptor antagonists related to openphendioxan: biological evaluation and α1d computational study 106
Novel muscarinic antagonists designed on the 1,4-dioxane scaffold 104
Coupling of I-1 Imidazoline Receptors to the cAMP Pathway: Studies with a Highly Selective Ligand, Benazoline 102
Alpha2C-adrenoceptor modulators: a patent review 102
Synergic stimulation of serotonin 5-HT1A receptor and α2-adrenoceptors for neuropathic pain relief: Preclinical effects of 2-substituted imidazoline derivatives 102
Totale 17.224
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Categoria #
all - tutte 63.001
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 63.001
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/2021941 0 0 0 0 0 83 159 20 132 60 322 165
2021/20221.016 88 241 15 74 66 61 25 75 74 118 63 116
2022/20231.528 176 54 66 238 172 204 10 102 284 87 85 50
2023/2024967 156 61 66 28 41 85 34 15 100 37 23 321
2024/20253.009 118 78 250 136 74 156 377 719 246 187 203 465
2025/20263.010 289 353 1.083 667 524 94 0 0 0 0 0 0
Totale 17.224