PIGINI, Maria
 Distribuzione geografica
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Continente #
NA - Nord America 6.783
EU - Europa 2.777
AS - Asia 1.046
Continente sconosciuto - Info sul continente non disponibili 39
SA - Sud America 11
OC - Oceania 8
AF - Africa 2
Totale 10.666
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Nazione #
US - Stati Uniti d'America 6.537
CN - Cina 977
DE - Germania 824
IT - Italia 559
UA - Ucraina 300
SE - Svezia 263
CA - Canada 244
GB - Regno Unito 210
FI - Finlandia 176
PL - Polonia 165
FR - Francia 129
IE - Irlanda 65
EU - Europa 35
BE - Belgio 34
IR - Iran 18
IN - India 14
TR - Turchia 13
NL - Olanda 11
RO - Romania 11
RU - Federazione Russa 11
AU - Australia 8
HK - Hong Kong 6
VN - Vietnam 6
A2 - ???statistics.table.value.countryCode.A2??? 4
BR - Brasile 4
RS - Serbia 4
CL - Cile 3
ES - Italia 3
KH - Cambogia 3
LT - Lituania 3
SG - Singapore 3
AR - Argentina 2
BG - Bulgaria 2
CH - Svizzera 2
HU - Ungheria 2
IL - Israele 2
BY - Bielorussia 1
DK - Danimarca 1
DZ - Algeria 1
IQ - Iraq 1
MN - Mongolia 1
MX - Messico 1
MY - Malesia 1
PA - Panama 1
PE - Perù 1
PT - Portogallo 1
TH - Thailandia 1
VE - Venezuela 1
ZA - Sudafrica 1
Totale 10.666
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Città #
Woodbridge 773
Jacksonville 745
Chandler 606
Fairfield 574
Ann Arbor 503
Wilmington 382
Houston 367
Ashburn 337
Nanjing 256
Seattle 227
Cambridge 187
Toronto 176
Dearborn 169
Düsseldorf 135
Kraków 123
San Mateo 117
Nanchang 98
Lawrence 93
Princeton 93
Beijing 92
Boardman 87
Columbus 86
Helsinki 82
Ogden 71
Lachine 67
Dublin 65
Kunming 57
Shenyang 56
Camerino 54
Tianjin 52
London 49
Venezia 44
Warsaw 42
Changsha 40
Hebei 37
New York 37
Brussels 34
Jinan 32
Nürnberg 32
Jiaxing 30
Milan 30
Hangzhou 28
San Diego 28
Venice 26
Philadelphia 25
Falls Church 24
Los Angeles 24
Zhengzhou 24
Washington 23
Guangzhou 19
Orange 19
Redwood City 19
Shanghai 19
Leawood 15
Ningbo 15
Taizhou 15
Monmouth Junction 14
Old Bridge 14
Verona 14
Fuzhou 13
Hefei 13
Kocaeli 12
Bremen 11
Centro 11
Changchun 11
Perugia 11
Ardabil 10
Auburn Hills 10
Lanzhou 9
Augusta 8
Baotou 8
Hanover 8
Indiana 8
Mountain View 8
Tulsa 8
Horia 7
Tappahannock 7
Berlin 6
Buffalo 6
Buti 6
Detroit 6
Dronten 6
Nuremberg 6
Strasbourg 6
West Jordan 6
New Delhi 5
Norwalk 5
Pesaro 5
Portland 5
Porto Sant'elpidio 5
Ascoli Piceno 4
Campbell 4
Campobasso 4
Chengdu 4
Council Bluffs 4
Hanoi 4
Hounslow 4
Jesi 4
Kharkiv 4
Latina 4
Totale 7.788
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Nome #
1,4-DIOXANE NUCLEUS AS A SUITABLE SCAFFOLD FOR NOVEL D2-LIKE RECEPTOR LIGANDS 242
The Versatile 2-Substituted Imidazoline Nucleus as a Structural Motif of Ligands Directed to the Serotonin 5-HT1A Receptor 239
1,4-Dioxane, a Suitable Scaffold for the Development of Novel M3 Muscarinic Receptor Antagonists 231
Hyperphagic effect of novel compounds with high affinity for imidazoline I2 binding sites 228
Antagonism/Agonism modulation to build novel antihypertensives selectively triggering i1-imidazoline receptor activation 208
A Novel Class of Dopamine D4 Receptor Ligands Bearing an Imidazoline Nucleus 196
Combined Interactions with I1-, I2-Imidazoline Binding Sites and α2-Adrenoceptors To Manage Opioid Addiction 196
1'-Benzyl-3,4-dihydrospiro[2H-1-benzothiopyran-2,4'-piperidine] (Spipethiane), a potent and highly selective sigma1 lingand 178
Novel ligands rationally designed for characterizing I2-imidazoline binding sites nature and functions 178
1,4-Dioxane ring as a promising template of novel 5-HT1A full agonists 168
Investigation of allyphenyline efficacy in the treatment of alcohol withdrawal symptoms 166
Discovery of Highly Selective Imidazoline Receptor Ligands 164
Structure-activity relationships in 1,4-benzodioxan-related compounds. Investigation on the role of the dehydrodioxane ring on alpha1-adrenoreceptor blocking activity 159
Biological profile and bioavailability of imidazoline compounds on morphine tolerance modulation 150
2-(2-Phenylcyclopropyl)imidazolines: Reversed Enantioselective Interaction at I1 and I2 Imidazoline Receptors 147
31st Camerino-Cyprus-Noordwijkerhout Symposium - Receptor Chemistry Skyline 144
Favourable involvement of α2A-adrenoreceptor antagonism in the I₂-imidazoline binding sites-mediated morphine analgesia enhancement. 141
Structure−Activity Relationships in 1,4-Benzodioxan-Related Compounds. 11.1 Reversed Enantioselectivity of 1,4-Dioxane Derivatives in α1‑Adrenergic and 5‑HT1A Receptor Binding Sites Recognition 140
“Pharmacological Characterization of Muscarinic Receptor Subtypes in Rabbit Isolated Tissue Preparations” 139
Novel Highly Potent and Selective σ1 Receptor Antagonists Related to Spipethiane 139
Novel Imidazoline Compounds as Partial or Full Agonists of D2-Like Dopamine Receptors Inspired by I2-Imidazoline Binding Sites Ligand 2-BFI 138
Use of frozen sections for the pharmacological characterization of compounds active on neurotransmitter receptors 138
Imidazoline binding sites (IBS) profile modulation: Key role of the bridge in determining I1-IBS or I2-IBS selectivity within a series of 2-phenoxymethylimidazoline analogues 138
Homoazanicotine: A structure-affinity study for nicotinic acetylcholine (nACh) receptor binding 137
Properly substituted 1,4-dioxane nucleus favours the selective M3 muscarinic receptor activation 137
Binding of nicotine and homoazanicotine analogues at neuronal nicotinic acetylcholinergic (nACh) receptors 135
Muscarinic Thioligands with Cyclopentane Nucleus 133
Chain-lengthened and imidazoline analogues of nicotine 131
Potent muscarinic antagonists bearing 1,4-dioxane scaffold 131
Muscarinic subtypes profile modulation within a series of new antagonists, bridged bicyclic derivatives of 2,2-diphenyl-[1,3]-dioxolan-4-ylmethyl-dimethylamine 130
Synthesis and muscarinic properties of (1S*,3R*,5R*)-trimethyl(1-methyl-6-oxabicyclo[3.1.0]hex-3-yl)methyl ammonium iodide 127
Low doses of allyphenyline and cyclomethyline, effective against morphine dependence, elicit an antidepressant-like effect 127
3-Phenyl analogues of 2-[[[2-(2,6-Dimethoxyphenoxyethyllamino]methyl]-1,4-benzodioxan (WB 4101) as highly selective alpha1-adrenoreceptor antagonists1 125
Synthesis and Structure-Activity Relationship Studies in a Series of 2-Substituted 1,3-Dioxolanes Modified at the Cationic Head. 125
alpha(2)-Adrenoreceptors profile modulation. 2. Biphenyline analogues as tools for selective activation of the alpha2C-subtype 124
Deoxamuscaroneoxime Devatives as useful Muscarinic Aginist to Explore the Muscarinic Subsite: Demox, Amodulator of Orthosteric and Allosteric Site at Cardiac Muscarinic M2 Receptors. 122
Dual Alpha2C/5HT1A Receptor Agonist Allyphenyline Induces Gastroprotection and Inhibits Fundic and Colonic Contractility 121
Exploring multitarget interactions to reduce opiate withdrawal syndrome and psychiatric comorbidity 120
Novel 1,4-dioxane derivatives as NMDA receptor channel blockers 119
Structure-activity relationships in 1,4-benzodioxan-related compounds. 7. Selectivity of 4-phenylchroman analogues for alpha(1)-adrenoreceptor subtypes 118
14th Camerino-Noordwijkerhout Symposium - Ongoing Progress in Receptor Chemistry 118
Synthesis, Absolute Configuration, and Biological Profile of the Enantiomers of trans-[2-(2,6-Dimethoxypheoxy)ethyl] [(3-p-tolyl-2,3-dihydro-1,4-benzodioxin-2-yl)methyl]amine (Mephendioxan), a Potent Competitive alpha 1A-Adrenoreceptor Antagonist 117
I1 imidazoline receptor-mediated effects on apoptotic processes in PC12 cells. 116
Might Adrenergic alpha2C-agonists/alpha2A-antagonists become novel therapeutic tools for pain treatment with morphine? 112
Imidazoline receptors: Qualitative structure-activity relationships and discovery of tracizoline and benazoline. Two ligands with high affinity and unprecedented selectivity 109
Ligand binding to I2 imidazoline receptor: the role of lipophilicity in quantitative structure-activity relationship models 107
Alpha(2)-Adrenoreceptors Profile Modulation. 3. (R)-(+)-m-Nitrobiphenyline, a New Efficient and alpha(2C)-Subtype Selective Agonist. 104
TESTING D2-LIKE RECEPTOR AFFINITY AND SELECTIVITY WITH NOVEL IMIDAZOLINE DERIVATIVES 101
From benzodioxane to 1,4-dioxane scaffold in the design of 5-HT1A serotoninergic full agonists from α1-adrenergic antagonists 100
Fruitful Adrenergic alpha(2C)-Agonism/alpha(2A)-Antagonism Combination to Prevent and Contrast Morphine Tolerance and Dependence 100
Structure-activity relationships in 1,4-benzodioxan-related compounds. 8.(1) {2-[2-(4 chlorobenzyloxy)phenoxy]ethyl}-[2-(2,6-dimethoxyphenoxy)ethyl]amine (clopenphendioxan) as a tool to highlight the involvement of alpha1D- and alpha1B-adrenoreceptor subtypes in the regulation of human PC-3 prostate cancer cell apoptosis and proliferation 100
Structure- Activity Relationships in 1,4-Benzodioxan-related Compounds. 4. Effect of aryl and alkyl Substituents at Position 3 on α-adrenoreceptor blocking activity 99
alpha(2)-adrenoreceptors profile modulation. 4. From antagonist, to agonist behavior 99
Alpha(2)-adrenoreceptors profile modulation and high antinociceptive activity of (S)-(-)-2-[1-(biphenyl-2-yloxy)ethyl]-4,5-dihydro-1H-imidazole 96
Design, synthesis and muscarinic activity of deoxamuscarine-related derivatives 96
31st Camerino-Cyprus-Noordwijkerhout Symposium - Receptor Chemistry Skyline 95
Molecular determinants in the binding of novel 1,4-benzodioxan-related α1D-adrenergic receptor antagonists: a computational study 94
28th Camerino-Cyprus-Noordwijkerhout Symposium - Trekking through Receptor Chemistry 93
Rational design of novel I1-imidazoline receptor agonists 92
16th Camerino-Noordwijkerhout Symposium - An Overview of Receptor Chemistry 92
Age-related Changes in the Density of Muscarinic Cholinergic M1 and M2 Receptor Subtypes in Pyramidal Neurons or the rat Hippocampus 92
Novel Dopamine Receptor Ligands Bearing Imidazoline Nucleus. 90
Structure-activity relationships in 1,4-benzodioxan-related compounds. 9.From 1,4-benzodioxan to 1,4-dioxane ring as a promising template of novel alpha(1D)-adrenoreceptor antagonists, 5-HT1A full agonists, and cytotoxic agents. 90
Imidazoline nucleus as a biologically versatile scaffold 89
Effects of allyphenyline on chronic alcohol intoxication model 89
Allyphenyline analogues potentially useful in the management of chronic pain and opioid addiction. 88
Structure-activity relationships in 1,4-benzodioxan-related compounds. 10. Novel alpha1-adrenoreceptor antagonists related to openphendioxan: synthesis, biological evaluation, and alpha1d computational study 88
Agonists and antagonists targeting the different alpha(2)-adrenoceptor subtypes 87
Structure-Activity Relationships in 1,4-Benzodioxan-Related Compounds. 6. Role of the Dioxane Unit on Selectivity for Alpha1-Adrenoreceptor Subtypes 87
Byciclic dioxolanes as potential antimuscarinic agents 87
Pharmacophore development and 3D-QSAR study of I1 imidazoline binding site ligands 87
Might adrenergic α2C-agonist/α2A-antagonist become a novel therapeutic multitarget tool for morphine chronic treatment of pain? 86
Copresence of 1,4-dioxane and quinuclidine nuclei in the design of novel muscarinic antagonists 85
NOVEL BIVALENT LIGANDS OF XANOMELINE AND 77-LH-28-1 AS POTENTIAL M1 MUSCARINIC AGONISTS 85
Separation of alpha-adrenergic and imidazoline/guanidinium receptive sites (IGRS) activity in a series of imidazoline analogues of cirazoline 85
Hybrid molecules from xanomeline and 77-LH-28-1 as potential novel M1 muscarinic agonists 84
Rational design of new alpha(2)-adrenoreceptor agonists 84
Might the observed alpha2A-adrenoreceptor agonism or antagonism of allyphenyline analogues be ascribed to different molecular conformations? 82
Enantioselective interactions to improve adrenergic α2C-agonism/α2A-antagonism 81
Alpha 1-adrenoreceptor antagonists bearing a quinazoline or a benzodioxane moiety 80
Structure- Activity Relationships in 1,4-Benzodioxan-related Compounds. 5. Effects of Modification of the side chain on alpha-adrenoreceptor blocking Activity 79
Enantiomers of 6,6-diphenyl-1,4-dioxane derivatives to highlight stereochemical requirements for selective alpha1D-AR and 5- HT1A receptor recognition 79
Adrenoceptors as targets in drug discovery: Medicinal chemistry and therapeutical potential 78
MORPHINE TOLERANCE MODULATION INDUCED BY alpha2-ADRENERGIC OR/AND I2 IMIDAZOLINE BINDING SITES LIGANDS 78
Structure-activity relationship at alpha-adrenergic receptors within a series of imidazoline analogues of cirazoline 78
Structural motives of imidazoline molecules favouring the serotonin 5-HT1A receptor activation 77
Binding of Tracizolines to the Imidazoline Receptor. Role of Lipophilicity in Quantitative Structure-Activity Relationship Models. 76
Coupling of I-1 Imidazoline Receptors to the cAMP Pathway: Studies with a Highly Selective Ligand, Benazoline 74
Alpha2C-adrenoceptor modulators: a patent review 73
Synthesis and alpha-blocking activity of some analogues of idazoxan 71
Synergic stimulation of serotonin 5-HT1A receptor and α2-adrenoceptors for neuropathic pain relief: Preclinical effects of 2-substituted imidazoline derivatives 71
Novel α1-adrenoreceptor antagonists related to openphendioxan: biological evaluation and α1d computational study 70
Novel muscarinic antagonists designed on the 1,4-dioxane scaffold 67
Totale 10.866
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Categoria #
all - tutte 35.737
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 35.737
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2018/2019497 0 0 0 0 0 0 0 0 0 0 193 304
2019/20202.388 316 85 239 406 129 277 246 233 125 142 51 139
2020/20211.440 79 119 81 137 83 83 159 20 132 60 322 165
2021/20221.016 88 241 15 74 66 61 25 75 74 118 63 116
2022/20231.528 176 54 66 238 172 204 10 102 284 87 85 50
2023/2024628 156 61 66 28 41 85 34 15 100 37 5 0
Totale 10.866