PIGINI, Maria
 Distribuzione geografica
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Continente #
NA - Nord America 10.190
EU - Europa 4.451
AS - Asia 3.795
SA - Sud America 416
AF - Africa 141
Continente sconosciuto - Info sul continente non disponibili 39
OC - Oceania 25
Totale 19.057
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Nazione #
US - Stati Uniti d'America 9.836
CN - Cina 1.720
SG - Singapore 1.051
RU - Federazione Russa 1.020
DE - Germania 931
IT - Italia 617
BR - Brasile 353
UA - Ucraina 310
CA - Canada 299
GB - Regno Unito 296
VN - Vietnam 283
SE - Svezia 276
FI - Finlandia 264
HK - Hong Kong 253
FR - Francia 250
PL - Polonia 200
TR - Turchia 117
ZA - Sudafrica 103
KR - Corea 98
IN - India 70
IE - Irlanda 68
CZ - Repubblica Ceca 51
BD - Bangladesh 50
BE - Belgio 45
MX - Messico 36
EU - Europa 35
JP - Giappone 33
NL - Olanda 29
AR - Argentina 27
IR - Iran 26
AU - Australia 23
ES - Italia 23
LT - Lituania 17
EC - Ecuador 14
IQ - Iraq 14
PK - Pakistan 12
RO - Romania 12
EG - Egitto 11
ID - Indonesia 9
MA - Marocco 8
RS - Serbia 7
AT - Austria 6
CO - Colombia 6
DZ - Algeria 6
PH - Filippine 6
AE - Emirati Arabi Uniti 5
CH - Svizzera 5
JM - Giamaica 5
JO - Giordania 5
KE - Kenya 5
NP - Nepal 5
SA - Arabia Saudita 5
TW - Taiwan 5
A2 - ???statistics.table.value.countryCode.A2??? 4
CL - Cile 4
HU - Ungheria 4
IL - Israele 4
PE - Perù 4
VE - Venezuela 4
AL - Albania 3
AZ - Azerbaigian 3
BG - Bulgaria 3
GR - Grecia 3
HN - Honduras 3
KH - Cambogia 3
MY - Malesia 3
NI - Nicaragua 3
PA - Panama 3
PY - Paraguay 3
SN - Senegal 3
BY - Bielorussia 2
DK - Danimarca 2
KG - Kirghizistan 2
KZ - Kazakistan 2
NZ - Nuova Zelanda 2
QA - Qatar 2
UZ - Uzbekistan 2
AD - Andorra 1
BH - Bahrain 1
BO - Bolivia 1
BZ - Belize 1
DO - Repubblica Dominicana 1
GA - Gabon 1
GE - Georgia 1
GH - Ghana 1
GT - Guatemala 1
HR - Croazia 1
IS - Islanda 1
LB - Libano 1
LC - Santa Lucia 1
LK - Sri Lanka 1
LV - Lettonia 1
LY - Libia 1
MK - Macedonia 1
MN - Mongolia 1
MT - Malta 1
MU - Mauritius 1
NG - Nigeria 1
PS - Palestinian Territory 1
PT - Portogallo 1
Totale 19.055
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Città #
Dallas 963
Woodbridge 773
Jacksonville 745
Ashburn 707
Chandler 606
Singapore 590
Fairfield 574
Ann Arbor 503
San Jose 397
Wilmington 383
Houston 377
Beijing 288
Boardman 286
Nanjing 258
Hong Kong 244
Seattle 234
Cambridge 188
Toronto 186
Dearborn 169
Los Angeles 165
The Dalles 153
Düsseldorf 139
New York 127
Kraków 123
Helsinki 119
San Mateo 117
Ho Chi Minh City 103
Council Bluffs 100
Columbus 98
Nanchang 98
Seoul 96
Johannesburg 95
Lawrence 93
Princeton 93
Tongling 93
Lauterbourg 90
Istanbul 86
Munich 74
Buffalo 73
Warsaw 73
Ogden 71
Dublin 68
Lachine 67
Moscow 66
London 61
Shanghai 59
Shenyang 59
Camerino 57
Kunming 57
Hanoi 56
Orem 56
Santa Clara 56
Tianjin 55
Guangzhou 50
São Paulo 46
Brussels 45
Venezia 44
Turku 43
Changsha 41
Jiaxing 41
Milan 41
Brno 40
Hebei 37
Chicago 35
Jinan 33
Hangzhou 32
Nürnberg 32
Chennai 31
San Diego 29
Tokyo 27
Philadelphia 26
Venice 26
Washington 26
Zhengzhou 26
Denver 25
Poplar 25
Falls Church 24
Frankfurt am Main 21
Wuhan 20
Boston 19
Orange 19
Redwood City 19
Brooklyn 18
Montreal 18
Da Nang 17
Manchester 17
Taizhou 17
Fuzhou 16
Amsterdam 15
Leawood 15
Mexico City 15
Ningbo 15
Phoenix 15
Stockholm 15
Verona 15
Atlanta 14
Monmouth Junction 14
Old Bridge 14
Hefei 13
Ankara 12
Totale 12.665
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Nome #
1,4-Dioxane, a Suitable Scaffold for the Development of Novel M3 Muscarinic Receptor Antagonists 623
1,4-DIOXANE NUCLEUS AS A SUITABLE SCAFFOLD FOR NOVEL D2-LIKE RECEPTOR LIGANDS 622
1,4-Dioxane ring as a promising template of novel 5-HT1A full agonists 560
1'-Benzyl-3,4-dihydrospiro[2H-1-benzothiopyran-2,4'-piperidine] (Spipethiane), a potent and highly selective sigma1 lingand 555
Antagonism/Agonism modulation to build novel antihypertensives selectively triggering i1-imidazoline receptor activation 339
The Versatile 2-Substituted Imidazoline Nucleus as a Structural Motif of Ligands Directed to the Serotonin 5-HT1A Receptor 332
31st Camerino-Cyprus-Noordwijkerhout Symposium - Receptor Chemistry Skyline 323
Hyperphagic effect of novel compounds with high affinity for imidazoline I2 binding sites 302
A Novel Class of Dopamine D4 Receptor Ligands Bearing an Imidazoline Nucleus 299
Combined Interactions with I1-, I2-Imidazoline Binding Sites and α2-Adrenoceptors To Manage Opioid Addiction 290
Novel ligands rationally designed for characterizing I2-imidazoline binding sites nature and functions 268
2-(2-Phenylcyclopropyl)imidazolines: Reversed Enantioselective Interaction at I1 and I2 Imidazoline Receptors 259
Investigation of allyphenyline efficacy in the treatment of alcohol withdrawal symptoms 252
Favourable involvement of α2A-adrenoreceptor antagonism in the I₂-imidazoline binding sites-mediated morphine analgesia enhancement. 250
Biological profile and bioavailability of imidazoline compounds on morphine tolerance modulation 243
alpha(2)-Adrenoreceptors profile modulation. 2. Biphenyline analogues as tools for selective activation of the alpha2C-subtype 237
14th Camerino-Noordwijkerhout Symposium - Ongoing Progress in Receptor Chemistry 236
Discovery of Highly Selective Imidazoline Receptor Ligands 224
Deoxamuscaroneoxime Devatives as useful Muscarinic Aginist to Explore the Muscarinic Subsite: Demox, Amodulator of Orthosteric and Allosteric Site at Cardiac Muscarinic M2 Receptors. 218
Imidazoline binding sites (IBS) profile modulation: Key role of the bridge in determining I1-IBS or I2-IBS selectivity within a series of 2-phenoxymethylimidazoline analogues 218
Structure-activity relationships in 1,4-benzodioxan-related compounds. Investigation on the role of the dehydrodioxane ring on alpha1-adrenoreceptor blocking activity 218
Binding of nicotine and homoazanicotine analogues at neuronal nicotinic acetylcholinergic (nACh) receptors 218
Novel 1,4-dioxane derivatives as NMDA receptor channel blockers 217
3-Phenyl analogues of 2-[[[2-(2,6-Dimethoxyphenoxyethyllamino]methyl]-1,4-benzodioxan (WB 4101) as highly selective alpha1-adrenoreceptor antagonists1 212
Structure−Activity Relationships in 1,4-Benzodioxan-Related Compounds. 11.1 Reversed Enantioselectivity of 1,4-Dioxane Derivatives in α1‑Adrenergic and 5‑HT1A Receptor Binding Sites Recognition 212
Novel Highly Potent and Selective σ1 Receptor Antagonists Related to Spipethiane 211
Structure-activity relationships in 1,4-benzodioxan-related compounds. 7. Selectivity of 4-phenylchroman analogues for alpha(1)-adrenoreceptor subtypes 209
31st Camerino-Cyprus-Noordwijkerhout Symposium - Receptor Chemistry Skyline 209
Novel Imidazoline Compounds as Partial or Full Agonists of D2-Like Dopamine Receptors Inspired by I2-Imidazoline Binding Sites Ligand 2-BFI 208
Design, synthesis and muscarinic activity of deoxamuscarine-related derivatives 208
Synthesis and muscarinic properties of (1S*,3R*,5R*)-trimethyl(1-methyl-6-oxabicyclo[3.1.0]hex-3-yl)methyl ammonium iodide 206
Muscarinic subtypes profile modulation within a series of new antagonists, bridged bicyclic derivatives of 2,2-diphenyl-[1,3]-dioxolan-4-ylmethyl-dimethylamine 204
Homoazanicotine: A structure-affinity study for nicotinic acetylcholine (nACh) receptor binding 202
16th Camerino-Noordwijkerhout Symposium - An Overview of Receptor Chemistry 201
Low doses of allyphenyline and cyclomethyline, effective against morphine dependence, elicit an antidepressant-like effect 200
Alpha(2)-Adrenoreceptors Profile Modulation. 3. (R)-(+)-m-Nitrobiphenyline, a New Efficient and alpha(2C)-Subtype Selective Agonist. 198
Use of frozen sections for the pharmacological characterization of compounds active on neurotransmitter receptors 197
Properly substituted 1,4-dioxane nucleus favours the selective M3 muscarinic receptor activation 197
28th Camerino-Cyprus-Noordwijkerhout Symposium - Trekking through Receptor Chemistry 195
Might Adrenergic alpha2C-agonists/alpha2A-antagonists become novel therapeutic tools for pain treatment with morphine? 193
Potent muscarinic antagonists bearing 1,4-dioxane scaffold 192
Enantioselective interactions to improve adrenergic α2C-agonism/α2A-antagonism 191
“Pharmacological Characterization of Muscarinic Receptor Subtypes in Rabbit Isolated Tissue Preparations” 190
Alpha(2)-adrenoreceptors profile modulation and high antinociceptive activity of (S)-(-)-2-[1-(biphenyl-2-yloxy)ethyl]-4,5-dihydro-1H-imidazole 189
Novel Dopamine Receptor Ligands Bearing Imidazoline Nucleus. 189
Allyphenyline analogues potentially useful in the management of chronic pain and opioid addiction. 188
Chain-lengthened and imidazoline analogues of nicotine 187
Muscarinic Thioligands with Cyclopentane Nucleus 187
Exploring multitarget interactions to reduce opiate withdrawal syndrome and psychiatric comorbidity 186
NOVEL BIVALENT LIGANDS OF XANOMELINE AND 77-LH-28-1 AS POTENTIAL M1 MUSCARINIC AGONISTS 183
Synthesis and Structure-Activity Relationship Studies in a Series of 2-Substituted 1,3-Dioxolanes Modified at the Cationic Head. 181
Synthesis, Absolute Configuration, and Biological Profile of the Enantiomers of trans-[2-(2,6-Dimethoxypheoxy)ethyl] [(3-p-tolyl-2,3-dihydro-1,4-benzodioxin-2-yl)methyl]amine (Mephendioxan), a Potent Competitive alpha 1A-Adrenoreceptor Antagonist 180
Age-related Changes in the Density of Muscarinic Cholinergic M1 and M2 Receptor Subtypes in Pyramidal Neurons or the rat Hippocampus 179
Ligand binding to I2 imidazoline receptor: the role of lipophilicity in quantitative structure-activity relationship models 179
Fruitful Adrenergic alpha(2C)-Agonism/alpha(2A)-Antagonism Combination to Prevent and Contrast Morphine Tolerance and Dependence 178
Structure-activity relationships in 1,4-benzodioxan-related compounds. 8.(1) {2-[2-(4 chlorobenzyloxy)phenoxy]ethyl}-[2-(2,6-dimethoxyphenoxy)ethyl]amine (clopenphendioxan) as a tool to highlight the involvement of alpha1D- and alpha1B-adrenoreceptor subtypes in the regulation of human PC-3 prostate cancer cell apoptosis and proliferation 178
TESTING D2-LIKE RECEPTOR AFFINITY AND SELECTIVITY WITH NOVEL IMIDAZOLINE DERIVATIVES 176
Agonists and antagonists targeting the different alpha(2)-adrenoceptor subtypes 175
Imidazoline receptors: Qualitative structure-activity relationships and discovery of tracizoline and benazoline. Two ligands with high affinity and unprecedented selectivity 173
alpha(2)-adrenoreceptors profile modulation. 4. From antagonist, to agonist behavior 172
Dual Alpha2C/5HT1A Receptor Agonist Allyphenyline Induces Gastroprotection and Inhibits Fundic and Colonic Contractility 172
Pharmacophore development and 3D-QSAR study of I1 imidazoline binding site ligands 171
Rational design of novel I1-imidazoline receptor agonists 170
MORPHINE TOLERANCE MODULATION INDUCED BY alpha2-ADRENERGIC OR/AND I2 IMIDAZOLINE BINDING SITES LIGANDS 169
Structure-activity relationships in 1,4-benzodioxan-related compounds. 9.From 1,4-benzodioxan to 1,4-dioxane ring as a promising template of novel alpha(1D)-adrenoreceptor antagonists, 5-HT1A full agonists, and cytotoxic agents. 169
Might adrenergic α2C-agonist/α2A-antagonist become a novel therapeutic multitarget tool for morphine chronic treatment of pain? 168
Adrenoceptors as targets in drug discovery: Medicinal chemistry and therapeutical potential 166
From benzodioxane to 1,4-dioxane scaffold in the design of 5-HT1A serotoninergic full agonists from α1-adrenergic antagonists 164
Imidazoline nucleus as a biologically versatile scaffold 162
I1 imidazoline receptor-mediated effects on apoptotic processes in PC12 cells. 162
Byciclic dioxolanes as potential antimuscarinic agents 161
Alpha 1-adrenoreceptor antagonists bearing a quinazoline or a benzodioxane moiety 159
Effects of allyphenyline on chronic alcohol intoxication model 157
Rational design of new alpha(2)-adrenoreceptor agonists 157
Structure- Activity Relationships in 1,4-Benzodioxan-related Compounds. 4. Effect of aryl and alkyl Substituents at Position 3 on α-adrenoreceptor blocking activity 156
Structure-activity relationship at alpha-adrenergic receptors within a series of imidazoline analogues of cirazoline 156
Hybrid molecules from xanomeline and 77-LH-28-1 as potential novel M1 muscarinic agonists 151
Structure-Activity Relationships in 1,4-Benzodioxan-Related Compounds. 6. Role of the Dioxane Unit on Selectivity for Alpha1-Adrenoreceptor Subtypes 143
Binding of Tracizolines to the Imidazoline Receptor. Role of Lipophilicity in Quantitative Structure-Activity Relationship Models. 143
Molecular determinants in the binding of novel 1,4-benzodioxan-related α1D-adrenergic receptor antagonists: a computational study 141
Separation of alpha-adrenergic and imidazoline/guanidinium receptive sites (IGRS) activity in a series of imidazoline analogues of cirazoline 137
Enantiomers of 6,6-diphenyl-1,4-dioxane derivatives to highlight stereochemical requirements for selective alpha1D-AR and 5- HT1A receptor recognition 136
Copresence of 1,4-dioxane and quinuclidine nuclei in the design of novel muscarinic antagonists 135
Structure-activity relationships in 1,4-benzodioxan-related compounds. 10. Novel alpha1-adrenoreceptor antagonists related to openphendioxan: synthesis, biological evaluation, and alpha1d computational study 131
Structural motives of imidazoline molecules favouring the serotonin 5-HT1A receptor activation 130
Might the observed alpha2A-adrenoreceptor agonism or antagonism of allyphenyline analogues be ascribed to different molecular conformations? 129
Novel muscarinic antagonists designed on the 1,4-dioxane scaffold 129
Structure- Activity Relationships in 1,4-Benzodioxan-related Compounds. 5. Effects of Modification of the side chain on alpha-adrenoreceptor blocking Activity 126
Synthesis and alpha-blocking activity of some analogues of idazoxan 122
Novel α1-adrenoreceptor antagonists related to openphendioxan: biological evaluation and α1d computational study 121
Coupling of I-1 Imidazoline Receptors to the cAMP Pathway: Studies with a Highly Selective Ligand, Benazoline 119
Synergic stimulation of serotonin 5-HT1A receptor and α2-adrenoceptors for neuropathic pain relief: Preclinical effects of 2-substituted imidazoline derivatives 116
Alpha2C-adrenoceptor modulators: a patent review 111
Totale 19.257
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Categoria #
all - tutte 69.645
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 69.645
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/2021165 0 0 0 0 0 0 0 0 0 0 0 165
2021/20221.016 88 241 15 74 66 61 25 75 74 118 63 116
2022/20231.528 176 54 66 238 172 204 10 102 284 87 85 50
2023/2024967 156 61 66 28 41 85 34 15 100 37 23 321
2024/20253.009 118 78 250 136 74 156 377 719 246 187 203 465
2025/20265.043 289 353 1.083 667 524 387 692 282 246 248 207 65
Totale 19.257