PIGINI, Maria
 Distribuzione geografica
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Continente #
NA - Nord America 6.856
EU - Europa 2.856
AS - Asia 1.425
Continente sconosciuto - Info sul continente non disponibili 39
SA - Sud America 12
OC - Oceania 9
AF - Africa 2
Totale 11.199
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Nazione #
US - Stati Uniti d'America 6.609
CN - Cina 1.245
DE - Germania 838
IT - Italia 567
UA - Ucraina 300
SE - Svezia 263
CA - Canada 244
GB - Regno Unito 210
FI - Finlandia 177
PL - Polonia 165
FR - Francia 129
SG - Singapore 114
IE - Irlanda 65
CZ - Repubblica Ceca 51
BE - Belgio 38
EU - Europa 35
IR - Iran 18
IN - India 14
TR - Turchia 13
RU - Federazione Russa 12
NL - Olanda 11
RO - Romania 11
AU - Australia 9
HK - Hong Kong 6
VN - Vietnam 6
BR - Brasile 5
A2 - ???statistics.table.value.countryCode.A2??? 4
RS - Serbia 4
CL - Cile 3
ES - Italia 3
KH - Cambogia 3
LT - Lituania 3
AR - Argentina 2
BG - Bulgaria 2
CH - Svizzera 2
HU - Ungheria 2
IL - Israele 2
BY - Bielorussia 1
DK - Danimarca 1
DZ - Algeria 1
IQ - Iraq 1
JM - Giamaica 1
MN - Mongolia 1
MX - Messico 1
MY - Malesia 1
PA - Panama 1
PE - Perù 1
PT - Portogallo 1
TH - Thailandia 1
VE - Venezuela 1
ZA - Sudafrica 1
Totale 11.199
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Città #
Woodbridge 773
Jacksonville 745
Chandler 606
Fairfield 574
Ann Arbor 503
Wilmington 382
Houston 367
Ashburn 346
Nanjing 258
Seattle 227
Cambridge 187
Toronto 176
Dearborn 169
Düsseldorf 135
Kraków 123
San Mateo 117
Beijing 116
Boardman 100
Nanchang 98
Lawrence 93
Princeton 93
Columbus 86
Helsinki 83
Ogden 71
Singapore 68
Lachine 67
Dublin 65
Shenyang 58
Kunming 57
Shanghai 56
Camerino 55
Tianjin 52
London 49
Guangzhou 47
Venezia 44
Warsaw 42
Brno 40
Changsha 40
Jiaxing 40
Los Angeles 39
Brussels 38
Hebei 37
New York 37
Jinan 33
Nürnberg 32
Milan 30
Hangzhou 29
San Diego 28
Venice 26
Philadelphia 25
Falls Church 24
Zhengzhou 24
Washington 23
Wuhan 20
Orange 19
Redwood City 19
Taizhou 17
Fuzhou 16
Leawood 15
Ningbo 15
Chicago 14
Monmouth Junction 14
Munich 14
Old Bridge 14
Verona 14
Hefei 13
Kocaeli 12
Bremen 11
Centro 11
Changchun 11
Olomouc 11
Perugia 11
Ardabil 10
Auburn Hills 10
Yiwu 10
Buffalo 9
Lanzhou 9
Augusta 8
Baotou 8
Hanover 8
Indiana 8
Mountain View 8
Tulsa 8
Horia 7
Tappahannock 7
Berlin 6
Buti 6
Detroit 6
Dronten 6
Nuremberg 6
Santa Clara 6
Strasbourg 6
West Jordan 6
Chengdu 5
Heze 5
Jinhua 5
New Delhi 5
Norwalk 5
Pesaro 5
Portland 5
Totale 8.097
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Nome #
1,4-Dioxane, a Suitable Scaffold for the Development of Novel M3 Muscarinic Receptor Antagonists 256
1,4-DIOXANE NUCLEUS AS A SUITABLE SCAFFOLD FOR NOVEL D2-LIKE RECEPTOR LIGANDS 255
The Versatile 2-Substituted Imidazoline Nucleus as a Structural Motif of Ligands Directed to the Serotonin 5-HT1A Receptor 244
Hyperphagic effect of novel compounds with high affinity for imidazoline I2 binding sites 235
Antagonism/Agonism modulation to build novel antihypertensives selectively triggering i1-imidazoline receptor activation 214
A Novel Class of Dopamine D4 Receptor Ligands Bearing an Imidazoline Nucleus 203
Combined Interactions with I1-, I2-Imidazoline Binding Sites and α2-Adrenoceptors To Manage Opioid Addiction 203
1'-Benzyl-3,4-dihydrospiro[2H-1-benzothiopyran-2,4'-piperidine] (Spipethiane), a potent and highly selective sigma1 lingand 191
Novel ligands rationally designed for characterizing I2-imidazoline binding sites nature and functions 183
1,4-Dioxane ring as a promising template of novel 5-HT1A full agonists 179
Investigation of allyphenyline efficacy in the treatment of alcohol withdrawal symptoms 170
Discovery of Highly Selective Imidazoline Receptor Ligands 166
Structure-activity relationships in 1,4-benzodioxan-related compounds. Investigation on the role of the dehydrodioxane ring on alpha1-adrenoreceptor blocking activity 161
Biological profile and bioavailability of imidazoline compounds on morphine tolerance modulation 156
2-(2-Phenylcyclopropyl)imidazolines: Reversed Enantioselective Interaction at I1 and I2 Imidazoline Receptors 154
31st Camerino-Cyprus-Noordwijkerhout Symposium - Receptor Chemistry Skyline 152
Favourable involvement of α2A-adrenoreceptor antagonism in the I₂-imidazoline binding sites-mediated morphine analgesia enhancement. 149
Novel Imidazoline Compounds as Partial or Full Agonists of D2-Like Dopamine Receptors Inspired by I2-Imidazoline Binding Sites Ligand 2-BFI 145
Structure−Activity Relationships in 1,4-Benzodioxan-Related Compounds. 11.1 Reversed Enantioselectivity of 1,4-Dioxane Derivatives in α1‑Adrenergic and 5‑HT1A Receptor Binding Sites Recognition 145
Novel Highly Potent and Selective σ1 Receptor Antagonists Related to Spipethiane 144
“Pharmacological Characterization of Muscarinic Receptor Subtypes in Rabbit Isolated Tissue Preparations” 143
Homoazanicotine: A structure-affinity study for nicotinic acetylcholine (nACh) receptor binding 142
Use of frozen sections for the pharmacological characterization of compounds active on neurotransmitter receptors 142
Properly substituted 1,4-dioxane nucleus favours the selective M3 muscarinic receptor activation 142
Imidazoline binding sites (IBS) profile modulation: Key role of the bridge in determining I1-IBS or I2-IBS selectivity within a series of 2-phenoxymethylimidazoline analogues 142
Binding of nicotine and homoazanicotine analogues at neuronal nicotinic acetylcholinergic (nACh) receptors 140
alpha(2)-Adrenoreceptors profile modulation. 2. Biphenyline analogues as tools for selective activation of the alpha2C-subtype 138
Muscarinic Thioligands with Cyclopentane Nucleus 138
Muscarinic subtypes profile modulation within a series of new antagonists, bridged bicyclic derivatives of 2,2-diphenyl-[1,3]-dioxolan-4-ylmethyl-dimethylamine 136
Chain-lengthened and imidazoline analogues of nicotine 136
Potent muscarinic antagonists bearing 1,4-dioxane scaffold 136
Synthesis and muscarinic properties of (1S*,3R*,5R*)-trimethyl(1-methyl-6-oxabicyclo[3.1.0]hex-3-yl)methyl ammonium iodide 132
Deoxamuscaroneoxime Devatives as useful Muscarinic Aginist to Explore the Muscarinic Subsite: Demox, Amodulator of Orthosteric and Allosteric Site at Cardiac Muscarinic M2 Receptors. 131
Low doses of allyphenyline and cyclomethyline, effective against morphine dependence, elicit an antidepressant-like effect 131
3-Phenyl analogues of 2-[[[2-(2,6-Dimethoxyphenoxyethyllamino]methyl]-1,4-benzodioxan (WB 4101) as highly selective alpha1-adrenoreceptor antagonists1 128
Synthesis and Structure-Activity Relationship Studies in a Series of 2-Substituted 1,3-Dioxolanes Modified at the Cationic Head. 128
Exploring multitarget interactions to reduce opiate withdrawal syndrome and psychiatric comorbidity 125
Dual Alpha2C/5HT1A Receptor Agonist Allyphenyline Induces Gastroprotection and Inhibits Fundic and Colonic Contractility 125
Structure-activity relationships in 1,4-benzodioxan-related compounds. 7. Selectivity of 4-phenylchroman analogues for alpha(1)-adrenoreceptor subtypes 124
14th Camerino-Noordwijkerhout Symposium - Ongoing Progress in Receptor Chemistry 124
Novel 1,4-dioxane derivatives as NMDA receptor channel blockers 123
Synthesis, Absolute Configuration, and Biological Profile of the Enantiomers of trans-[2-(2,6-Dimethoxypheoxy)ethyl] [(3-p-tolyl-2,3-dihydro-1,4-benzodioxin-2-yl)methyl]amine (Mephendioxan), a Potent Competitive alpha 1A-Adrenoreceptor Antagonist 122
I1 imidazoline receptor-mediated effects on apoptotic processes in PC12 cells. 120
Might Adrenergic alpha2C-agonists/alpha2A-antagonists become novel therapeutic tools for pain treatment with morphine? 118
Imidazoline receptors: Qualitative structure-activity relationships and discovery of tracizoline and benazoline. Two ligands with high affinity and unprecedented selectivity 115
Ligand binding to I2 imidazoline receptor: the role of lipophilicity in quantitative structure-activity relationship models 111
Alpha(2)-Adrenoreceptors Profile Modulation. 3. (R)-(+)-m-Nitrobiphenyline, a New Efficient and alpha(2C)-Subtype Selective Agonist. 110
Fruitful Adrenergic alpha(2C)-Agonism/alpha(2A)-Antagonism Combination to Prevent and Contrast Morphine Tolerance and Dependence 108
From benzodioxane to 1,4-dioxane scaffold in the design of 5-HT1A serotoninergic full agonists from α1-adrenergic antagonists 106
alpha(2)-adrenoreceptors profile modulation. 4. From antagonist, to agonist behavior 106
Structure-activity relationships in 1,4-benzodioxan-related compounds. 8.(1) {2-[2-(4 chlorobenzyloxy)phenoxy]ethyl}-[2-(2,6-dimethoxyphenoxy)ethyl]amine (clopenphendioxan) as a tool to highlight the involvement of alpha1D- and alpha1B-adrenoreceptor subtypes in the regulation of human PC-3 prostate cancer cell apoptosis and proliferation 106
31st Camerino-Cyprus-Noordwijkerhout Symposium - Receptor Chemistry Skyline 105
TESTING D2-LIKE RECEPTOR AFFINITY AND SELECTIVITY WITH NOVEL IMIDAZOLINE DERIVATIVES 104
Structure- Activity Relationships in 1,4-Benzodioxan-related Compounds. 4. Effect of aryl and alkyl Substituents at Position 3 on α-adrenoreceptor blocking activity 103
Design, synthesis and muscarinic activity of deoxamuscarine-related derivatives 103
16th Camerino-Noordwijkerhout Symposium - An Overview of Receptor Chemistry 102
Alpha(2)-adrenoreceptors profile modulation and high antinociceptive activity of (S)-(-)-2-[1-(biphenyl-2-yloxy)ethyl]-4,5-dihydro-1H-imidazole 101
28th Camerino-Cyprus-Noordwijkerhout Symposium - Trekking through Receptor Chemistry 101
Molecular determinants in the binding of novel 1,4-benzodioxan-related α1D-adrenergic receptor antagonists: a computational study 99
Age-related Changes in the Density of Muscarinic Cholinergic M1 and M2 Receptor Subtypes in Pyramidal Neurons or the rat Hippocampus 99
Novel Dopamine Receptor Ligands Bearing Imidazoline Nucleus. 98
Rational design of novel I1-imidazoline receptor agonists 97
Allyphenyline analogues potentially useful in the management of chronic pain and opioid addiction. 95
Effects of allyphenyline on chronic alcohol intoxication model 94
Pharmacophore development and 3D-QSAR study of I1 imidazoline binding site ligands 94
Structure-activity relationships in 1,4-benzodioxan-related compounds. 9.From 1,4-benzodioxan to 1,4-dioxane ring as a promising template of novel alpha(1D)-adrenoreceptor antagonists, 5-HT1A full agonists, and cytotoxic agents. 94
Agonists and antagonists targeting the different alpha(2)-adrenoceptor subtypes 93
Imidazoline nucleus as a biologically versatile scaffold 93
Structure-Activity Relationships in 1,4-Benzodioxan-Related Compounds. 6. Role of the Dioxane Unit on Selectivity for Alpha1-Adrenoreceptor Subtypes 92
Byciclic dioxolanes as potential antimuscarinic agents 92
Structure-activity relationships in 1,4-benzodioxan-related compounds. 10. Novel alpha1-adrenoreceptor antagonists related to openphendioxan: synthesis, biological evaluation, and alpha1d computational study 91
Copresence of 1,4-dioxane and quinuclidine nuclei in the design of novel muscarinic antagonists 89
Might adrenergic α2C-agonist/α2A-antagonist become a novel therapeutic multitarget tool for morphine chronic treatment of pain? 89
NOVEL BIVALENT LIGANDS OF XANOMELINE AND 77-LH-28-1 AS POTENTIAL M1 MUSCARINIC AGONISTS 89
Rational design of new alpha(2)-adrenoreceptor agonists 88
Separation of alpha-adrenergic and imidazoline/guanidinium receptive sites (IGRS) activity in a series of imidazoline analogues of cirazoline 88
Hybrid molecules from xanomeline and 77-LH-28-1 as potential novel M1 muscarinic agonists 86
Adrenoceptors as targets in drug discovery: Medicinal chemistry and therapeutical potential 85
Might the observed alpha2A-adrenoreceptor agonism or antagonism of allyphenyline analogues be ascribed to different molecular conformations? 85
Enantioselective interactions to improve adrenergic α2C-agonism/α2A-antagonism 85
Enantiomers of 6,6-diphenyl-1,4-dioxane derivatives to highlight stereochemical requirements for selective alpha1D-AR and 5- HT1A receptor recognition 85
Alpha 1-adrenoreceptor antagonists bearing a quinazoline or a benzodioxane moiety 84
Binding of Tracizolines to the Imidazoline Receptor. Role of Lipophilicity in Quantitative Structure-Activity Relationship Models. 84
Structure- Activity Relationships in 1,4-Benzodioxan-related Compounds. 5. Effects of Modification of the side chain on alpha-adrenoreceptor blocking Activity 83
MORPHINE TOLERANCE MODULATION INDUCED BY alpha2-ADRENERGIC OR/AND I2 IMIDAZOLINE BINDING SITES LIGANDS 83
Structure-activity relationship at alpha-adrenergic receptors within a series of imidazoline analogues of cirazoline 82
Structural motives of imidazoline molecules favouring the serotonin 5-HT1A receptor activation 80
Coupling of I-1 Imidazoline Receptors to the cAMP Pathway: Studies with a Highly Selective Ligand, Benazoline 79
Alpha2C-adrenoceptor modulators: a patent review 77
Synthesis and alpha-blocking activity of some analogues of idazoxan 76
Novel α1-adrenoreceptor antagonists related to openphendioxan: biological evaluation and α1d computational study 75
Synergic stimulation of serotonin 5-HT1A receptor and α2-adrenoceptors for neuropathic pain relief: Preclinical effects of 2-substituted imidazoline derivatives 74
Novel muscarinic antagonists designed on the 1,4-dioxane scaffold 70
Totale 11.399
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Categoria #
all - tutte 40.615
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 40.615
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2019/20202.072 0 85 239 406 129 277 246 233 125 142 51 139
2020/20211.440 79 119 81 137 83 83 159 20 132 60 322 165
2021/20221.016 88 241 15 74 66 61 25 75 74 118 63 116
2022/20231.528 176 54 66 238 172 204 10 102 284 87 85 50
2023/2024967 156 61 66 28 41 85 34 15 100 37 23 321
2024/2025194 118 76 0 0 0 0 0 0 0 0 0 0
Totale 11.399