The replacement of the carbon chain separating the amine and the phenoxy groups of 21 with a cyclopentane ring afforded stereoisomers (-)-31, (+)-31, (-)-32 and (+)-32 that retained good affinity for alpha1 adrenoreceptor subtypes or 5-HT1A receptors according to the cnfiguration of cyclopentane unit.
Alpha 1-adrenoreceptor antagonists bearing a quinazoline or a benzodioxane moiety
ANGELI, Piero;MARUCCI, Gabriella;PIGINI, Maria;QUAGLIA, Wilma;
2000-01-01
Abstract
The replacement of the carbon chain separating the amine and the phenoxy groups of 21 with a cyclopentane ring afforded stereoisomers (-)-31, (+)-31, (-)-32 and (+)-32 that retained good affinity for alpha1 adrenoreceptor subtypes or 5-HT1A receptors according to the cnfiguration of cyclopentane unit.File in questo prodotto:
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