Two new cocrystalline compounds, (Hen)(H2L2)$2/3H2O (2) and (Him)(H3L3)$2H2O (8), were prepared by the reaction of 5-(2-(4-chlorophenyl)hydrazono)pyrimidine-2,4,6(1H,3H,5H)-trione (H3L2) and the sodium salt of 2-(2-(2,4,6-trioxotetrahydropyrimidin-5(2H)-ylidene)hydrazinyl)benzenesulfonic acid (H4L3), [Na(H3L3)(m-H2O)(H2O)2]2 (1) with protonated ethylenediamine (Hen) and imidazole (Him), respectively. By using 5-(2-(2-hydroxyphenyl)hydrazono)pyrimidine-2,4,6(1H,3H,5H)-trione (H4L1) and 1, several known CuII, CoII, CoII/III and new AgI complexes, [Cu(H2L1)(H2O)(im)]$3H2O (3), [Co(H2O)6]- [Co(H2L1)2]2$8H2O (4), [Co(H2L3)(im)3] (5), [Cu(H2L3)(im)2]$H2O (6), [Ag(H2O)(m-H3L3)]n (7) and [Co(H2O)6]- [H3L3]2$8H2O (9), were also prepared in order to study their DNA and BSA binding, anticancer and antimicrobial properties. The complexes are able to interact with DNA and BSA with high binding constant values. In particular, complex 4 strongly intercalates DNA and binds BSA. The antimicrobial activity of all compounds, determined against a panel of reference bacterial and fungal strains, indicates that only 2 and 7 possess antimicrobial activity. The same compounds 2 and 7 show a pronounced antiproliferative activity against the human tumor cell lines A375, MDA-MB 231 and HCT116.
DNA and BSA binding, anticancer and antimicrobial properties of Co(II), Co(II/III), Cu(II) and Ag(I) complexes of arylhydrazones of barbituric acid
PALMUCCI, JESSICA;MARCHETTI, Fabio;PETTINARI, Claudio;PETRELLI, Dezemona;VITALI, Luca Agostino;QUASSINTI, Luana;BRAMUCCI, Massimo;LUPIDI, Giulio;
2016-01-01
Abstract
Two new cocrystalline compounds, (Hen)(H2L2)$2/3H2O (2) and (Him)(H3L3)$2H2O (8), were prepared by the reaction of 5-(2-(4-chlorophenyl)hydrazono)pyrimidine-2,4,6(1H,3H,5H)-trione (H3L2) and the sodium salt of 2-(2-(2,4,6-trioxotetrahydropyrimidin-5(2H)-ylidene)hydrazinyl)benzenesulfonic acid (H4L3), [Na(H3L3)(m-H2O)(H2O)2]2 (1) with protonated ethylenediamine (Hen) and imidazole (Him), respectively. By using 5-(2-(2-hydroxyphenyl)hydrazono)pyrimidine-2,4,6(1H,3H,5H)-trione (H4L1) and 1, several known CuII, CoII, CoII/III and new AgI complexes, [Cu(H2L1)(H2O)(im)]$3H2O (3), [Co(H2O)6]- [Co(H2L1)2]2$8H2O (4), [Co(H2L3)(im)3] (5), [Cu(H2L3)(im)2]$H2O (6), [Ag(H2O)(m-H3L3)]n (7) and [Co(H2O)6]- [H3L3]2$8H2O (9), were also prepared in order to study their DNA and BSA binding, anticancer and antimicrobial properties. The complexes are able to interact with DNA and BSA with high binding constant values. In particular, complex 4 strongly intercalates DNA and binds BSA. The antimicrobial activity of all compounds, determined against a panel of reference bacterial and fungal strains, indicates that only 2 and 7 possess antimicrobial activity. The same compounds 2 and 7 show a pronounced antiproliferative activity against the human tumor cell lines A375, MDA-MB 231 and HCT116.File | Dimensione | Formato | |
---|---|---|---|
RSC ADVANCES 2016, 6, 4237-4249.pdf
accesso aperto
Descrizione: Articolo principale
Tipologia:
Versione Editoriale
Licenza:
PUBBLICO - Creative Commons
Dimensione
1.1 MB
Formato
Adobe PDF
|
1.1 MB | Adobe PDF | Visualizza/Apri |
RSC ADVANCES 2016, 6, Suppl. mat.pdf
accesso aperto
Tipologia:
Versione Editoriale
Licenza:
PUBBLICO - Creative Commons
Dimensione
8.75 MB
Formato
Adobe PDF
|
8.75 MB | Adobe PDF | Visualizza/Apri |
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.