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Abstract su rivista 47
Altre tipologie di pubblicazione (Recensione) 233
Articolo 15353
Nota a sentenza 85
Scheda bibliografica 9
Traduzione (Rivista) 15

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NOP receptor antagonism reduces alcohol drinking in male and female rats through mechanisms involving the central amygdala and ventral tegmental area

Nociceptin/orphanin FQ (N/OFQ) peptide and its cognate receptor (NOP) are widely expressed in mesolimbic brain regions where they play an important role in modulating reward and motivation. Early evidence suggested that NOP receptor activation attenuates the rewarding effects of drugs of abuse, including alcohol. However, emerging data indicate that NOP receptor blockade also effectively attenuates alcohol drinking and relapse. To advance our understanding of the role of the N/OFQ-NOP recepto...

Process-oriented knowledge management and learning in public administrations

The capability to easily access and acquire knowledge is a key enabler for complex organisations that need to adapt to frequent changes of their operative contexts. These changes generally challenge workers that need to acquire new competences and skills. Such a situation is particularly evident in public administrations that nowadays are undergoing complex re-organisations in order to implement new regulations, and to deliver simplified services to both citizens and enterprises. This paper r...

The Au-Ag (Zn, Pb, Mo, Cu) Sulfuro Vein, La Paloma district, Deseado Massif, Argentina: Geochemical characterization and new insights into the 4D evolution of ore shoots

Unravelling the 3D architecture of ore shoots and its evolution through time, thereby moving towards a 4D understanding of mineralization processes, requires an interdisciplinary approach based on the capability of carrying out extensive trenching and drilling as well as effectively integrating structural and geochemical analyses. Such conditions are offered in La Paloma district of the Deseado Massif, Argentina. Here, eight epithermal Au-Ag veins are hosted in Middle Jurassic volcanic rocks ...

RLN3/RXFP3 Signaling in the PVN Inhibits Magnocellular Neurons via M-like Current Activation and Contributes to Binge Eating Behavior

Binge-eating disorder is the most common eating disorder. Various neuropeptides play important roles in the regulation of feeding behavior, including relaxin-3 (RLN3), which stimulates food intake in rats through the activation of the relaxin-family peptide-3 receptor (RXFP3). Here we demonstrate that a likely mechanism underlying the orexigenic action of RLN3 is RXFP3-mediated inhibition of oxytocin- and arginine-vasopressin-synthesizing paraventricular nucleus (PVN) magnocellular neurosecre...

RLN3/RXFP3 signaling in the PVN inhibits magnocellular neurons via M-like current activation and contributes to binge eating behavior

Binge-eating disorder (BED) is the most common eating disorder. Various neuropeptides play important role in the regulation of feeding behavior, including relaxin-3 (RLN3), which stimulates food intake through the activation of relaxin-family peptide 3 receptor (RXFP3). We demonstrated that the likely mechanism underlying RLN3 orexigenic action involves RXFP3-mediated inhibition of oxytocin- and arginine-vasopressin-synthesizing PVN magnocellular neurosecretory cells. Moreover, we showed that...

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