Two triterpenoid saponins have been isolated from the seed kernels of Entada rheedii. Their structures have been established using 1D- and 2D-NMR and mass spectrometry as 3-O-b-D-xylopyranosyl- (1 -3)-O-a-L-arabinopyranosyl-(1 -6)-2-acetylamino-2-deoxy-b-D-glucopyranosylentagenic acid 28- O-b-apiofuranosyl-(1-3)-b-D-xylopyranosyl-(1 -2)-b-D-glucopyranoside (Rheediinoside A, 1) and 3-O-b-D-glucopyranosyl-(1 -3)-O-[b-D-xylopyranosyl-(1-3)-a-L-arabinopyranosyl-(1 -6)]-2-acetylamino- 2-deoxy-b-D-glucopyranosylentagenic acid 28-O-b-apiofuranosyl-(1-3)-b-D-xylopyranosyl- (1-2)-b-D-glucopyranoside (Rheediinoside B, 2). Compounds 1 and 2 were tested for their antiproliferative activity against T98G, A431, PC3 and B16-F1 cell lines, and further for their antioxidant properties. Moderate cytotoxic potency and antioxidant properties were found for these compounds whereas Rheediinoside B was in all assays more active than Rheediinoside A.
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|Titolo:||Rheediinosides A and B, two antiproliferative and antioxidant triterpene saponins from Entada rheedii|
|Data di pubblicazione:||2010|
|Appare nelle tipologie:||Articolo|