Next-Generation Technologies for the Development of Novel C-C and C-X Bond Formation Pathways from Functionalized Nitroolefins

This thesis explores the “Next-Generation Technologies for the Development of Novel C–C and C–X Bond Formation Pathways from Functionalized Nitroolefins” with the aim of developing green and sustainable synthetic methodologies for biologically important molecules. The First chapter enlights the emerging trends and technologies being used in the modern organic synthesis with a focus on photochemistry, flow-chemistry, microwave irradiation and one-pot reactions. The second chapter encounters my research work conducted at University of Camerino (Chemistry Interdisciplinary Project, ChIP, Camerino, Italy) in the Green Chemistry Group, under the supervision of Prof. Alessandro Palmieri, where I specifically studied the reactivity of  -nitroenones and explored the possibility to utilize them as a precursor for various bioactive heterocyclic systems including pyridazines, Isoxazoles, and conjugated nitrotriene systems. These works promoted sustainability in terms of green energy conditions including microwave, photochemistry and flow chemistry. The third chapter describes my research work performed during visiting research stay at the State key laboratory of Green Chemistry and Chemical process at East China Normal University, Shanghai, China. Where I worked with Dr. Xuefeng Jiang on the selective C-H activation of alkyl benzenes under photochemical conditions. In parallel to the core project, I was also involved in co-authorship of a review article published in Artificial Intelligence Chemistry.