9 TESI DI DOTTORATO

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Tesi di dottorato 376

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Machine Learning in clinical biology and medicine: from prediction of multidrug resistant infections in humans to pre-mRNA splicing control in Ciliates

Machine Learning methods have broadly begun to infiltrate the clinical literature in such a way that the correct use of algorithms and tools can facilitate both diagnosis and therapies. The availability of large quantities of high-quality data could lead to an improved understanding of risk factors in community and healthcare-acquired infections. In the first part of my PhD program, I refined my skills in Machine Learning by developing and evaluate with a real antibiotic stewardship data...

Electron Spectroscopy with the SLICES setup

The subject of this thesis is the setup of a new spectrometer for internal conversion elec- tron measurements, SLICES (Spes Low energy Internal Conversion Electron Spectrom- eter), and its first use in an experiment aimed to study the structure of the low-lying states in 106Pd. Electron spectroscopy is a powerful tool in the investigation of fundamental properties of the atomic nucleus, essential in the study of nuclear structure, where empirical nuclear models provide a framework to ...

Machine Learning applications to e-learning courses

The Ph.D. thesis project is aimed at improving the quality and the effectiveness of on-line teaching in scientific degree courses at the University Level that required the use of E-learning platform, based on the Moodle Content Management System. The aim of this research project is to assist the teacher, through the development of new tools based on Artificial Intelligence, to design innovative successful e-learning courses to give to the students the opportunity to improve their learni...

The role of stress, sex and early-life environment in shaping alcohol vulnerability

Background: Genetically-selected Marchigian Sardinian alcohol-preferring (msP) rats represent a unique animal model of excessive alcohol drinking and anxiety disorder. They show innate upregulation of the corticotropin-releasing factor receptor 1 (CRF1) which correlates with heightened ethanol consumption and stress sensitivity. Stress, dysregulation of the hypothalamic-pituitary-adrenal axis (HPA) and alterations in glucocorticoid receptor (GR) function have been linked to transition fr...

Impact of individual differences in the development of opioid dependence

Opioid use disorder (OUD) is a chronic relapsing brain disease characterized by compulsion to seek and take the drug despite adverse consequences that has recently risen epidemic proportion becoming a global health problem. Opioids belong to a class of highly addictive narcotics used for pain management in a number of acute and chronic medical conditions; however their abuse leads to tolerance, dependence and risk of overdose. By binding opioid receptors in many areasof the brain involve...

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