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Analysis of the Associations Among Gut Microbiota, Intestinal Parasites, and Nutritional Conditions in Mothers and Children from Zanzibar, Tanzania

Large intestine-dwelling helminths affect microbiome composition. In sub-Saharan Africa, where helminth infections are endemic, the use of chemotherapeutic drugs is the primary strategy for controlling soil-transmitted helminthiases (STHs). However, the emergence of anthelmintic resistance necessitates the urgent exploration of alternative and complementary treatments to achieve the World Health Organization’s goal of eliminating STHs. One promising avenue involves the manipulation of gu...

Model-Driven Engineering for IoT Applications: a focus on Reusability and Portability

The Internet of Things (IoT) has ushered in a paradigm shift, reshaping our worldview and unlocking new horizons for delivering advanced services by connecting billions of devices and sensors. Complexity characterises the landscape of IoT applications, as they encompass heterogeneous devices with different scopes, from manufacturers that use distinct communication protocols, producing diverse data types and computational capabilities that hinder their interoperability. This heterogenei...

Mechanism of walnut-derived antioxidant pepetides for improving learning and memory dysfunction

Walnut residues, the byproducts of walnut oil extraction, are often regarded as waste or used as low-value feed, fertilizer, etc. However, walnut residues are rich in proteins (40-55%) and have a multitude of physiological and pharmacological properties that provide a wide range of potential applications for the generation of bioactive peptides. In this thesis work, the neuroprotective effect of walnut-derived peptides on learning and memory dysfunction was addressed. Firstly, CHAPTER 1...

Valorization of Edible Mushroom and Fish Waste for the production of Vitamin D

This study highlights the importance of looking into novel approaches to optimize the use of mushroom and fish waste as a beneficial source of vitamin D, which can help address nutritional deficiencies and promote sustainable practices in food production by utilizing the potential of fish waste. This study contributes to the larger objective of efficiently producing vital nutrients like vitamin D from food by-products, such as edible mushroom and fish waste. Furthermore, it also increase...

PFAS: a new threat to human health Multi-analyte method development and background levels monitoring

“PFAS are defined as fluorinated substances that contain at least one fully fluorinated methyl or methylene carbon atom (without any H/Cl/Br/I atom attached to it), i.e., with a few noted exceptions, any chemical with at least a perfluorinated methyl group (−CF3) or a perfluorinated methylene group (−CF2−) is a PFAS”. The “noted exceptions” refer to a carbon atom with a H/Cl/Br/I atom attached to it (Organisation for Economic Co-operation and Development (OECD), 2021; Wang et al., 2021). ...

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