The search for new bioactive substances with anticancer activity and the understanding of their mechanisms of action are high priorities in the research effort toward more effective cancer treat- ments. In this article, we analyzed, for the first time, the chemical composition of the essential oil (EO) hydrodistilled from the aerial parts of Vicia ochroleuca Ten. (Leguminosae) by GC–MS. A total of sixteen compounds representing 82.2% of the total composition were identified. The major compounds were phytone (20.11%), hexadecanoic acid (10.23%), 1-octen-3-ol (9.84%), and 10-epi- a-cadinol (7.13%). Additionally, using the MTT (3-[4,5-dimethylthia- zol-2-yl]-2,5-diphenyltetrazolium bromide) method, the EO was tested in vitro against a panel of human cancer cells, including breast (MDA-MB 231), colon (HCT116), melanoma (A375), and glioblastoma (T98G), with corresponding IC50 values of 23.07, 47.05, 51.64, and 64.07lg/mL, respectively. The results demon- strate cytotoxic activity and suggest that V. ochroleuca EO could be regarded as a natural bioactive source.

Chemical composition and anticancer activity of the essential oil from Vicia ochroleuca Ten., Quite rare plant in Kabylia (Algeria)

M. Bramucci
Secondo
;
L. Quassinti;F. Maggi
Ultimo
2023-01-01

Abstract

The search for new bioactive substances with anticancer activity and the understanding of their mechanisms of action are high priorities in the research effort toward more effective cancer treat- ments. In this article, we analyzed, for the first time, the chemical composition of the essential oil (EO) hydrodistilled from the aerial parts of Vicia ochroleuca Ten. (Leguminosae) by GC–MS. A total of sixteen compounds representing 82.2% of the total composition were identified. The major compounds were phytone (20.11%), hexadecanoic acid (10.23%), 1-octen-3-ol (9.84%), and 10-epi- a-cadinol (7.13%). Additionally, using the MTT (3-[4,5-dimethylthia- zol-2-yl]-2,5-diphenyltetrazolium bromide) method, the EO was tested in vitro against a panel of human cancer cells, including breast (MDA-MB 231), colon (HCT116), melanoma (A375), and glioblastoma (T98G), with corresponding IC50 values of 23.07, 47.05, 51.64, and 64.07lg/mL, respectively. The results demon- strate cytotoxic activity and suggest that V. ochroleuca EO could be regarded as a natural bioactive source.
2023
262
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Natural Product Research 2023, vol. 37 n. 24 pp. 4181-4187 Chemical composition and anticancer activity of the essential oil from Vicia ochroleuca Ten. quite rare plant in Kabylia Algeria .pdf

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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11581/468934
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