Potential neuroprotective effect of spent coffee grounds extracts against neurodegeneration

Spent Coffee Grounds (SCG), a waste product of the coffee industry, are a renewable source of a wide range of nutraceutical compounds. Coffee wastes are particularly rich in phenols like phenolic acids such as chlorogenic, ellagic, caffeic, gallic, trans-ferulic, p-coumaric, p-hydroxybenzoic, tannic, and protocatechuic acids; flavonoids such as rutin, catechin, epicatechin, and quercetin. The positive effects of polyphenols in counteracting neurodegeneration have been highlighted by several studies. Although neurodegenerative diseases have a multifactorial aetiology, oxidative stress and neuroinflammation play a key role in their onset.