A catalyst-free heterocyclization reaction of -chloroglycinates with thiobenzamides or thioureas leading to 2,4-disubstituted-5-acylamino-1,3-thiazoles has been developed. The methodology provides straightforward access to valuable building blocks for pharmaceutically relevant compounds.

Catalyst-Free Synthesis of Polysubstituted 5-Acylamino-1,3-Thiazoles via Hantzsch Cyclization of α-Chloroglycinates

Mara Tomassetti
;
Gabriele Lupidi;Pamela Piermattei;Federico V. Rossi;Enrico Marcantoni
2019-01-01

Abstract

A catalyst-free heterocyclization reaction of -chloroglycinates with thiobenzamides or thioureas leading to 2,4-disubstituted-5-acylamino-1,3-thiazoles has been developed. The methodology provides straightforward access to valuable building blocks for pharmaceutically relevant compounds.
2019
262
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11581/447427
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