A catalyst-free heterocyclization reaction of -chloroglycinates with thiobenzamides or thioureas leading to 2,4-disubstituted-5-acylamino-1,3-thiazoles has been developed. The methodology provides straightforward access to valuable building blocks for pharmaceutically relevant compounds.
Catalyst-Free Synthesis of Polysubstituted 5-Acylamino-1,3-Thiazoles via Hantzsch Cyclization of α-Chloroglycinates
Mara Tomassetti
;Gabriele Lupidi;Pamela Piermattei;Federico V. Rossi;Enrico Marcantoni
2019-01-01
Abstract
A catalyst-free heterocyclization reaction of -chloroglycinates with thiobenzamides or thioureas leading to 2,4-disubstituted-5-acylamino-1,3-thiazoles has been developed. The methodology provides straightforward access to valuable building blocks for pharmaceutically relevant compounds.File in questo prodotto:
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Molecules 2019, 24, 3846.pdf
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