L-arginine is an essential precursor for the production of nitric oxide (NO) which mediates the protective effects of the intact endothelium, acting as a vasodilator and endogenous antiatherogenic factor [...]. Furthermore, NO plays an important role in the regulation of the renal blood flow, glomerular filtration rate and saline homeostasis [...] The effects of arginine administration have been investigated in humans affected by cardiovascular diseases [...]. In hypertensive patients under pharmacological therapies, oral administration of arginine for six weeks resulted in a reduction in systolic and diastolic blood pressure [...] At the present time, there is a paucity of data about the role of L- arginine in chronic cardiovascular and kidney disease in dogs. On the basis of the current literature, the objective of this research was to assess the effectiveness of oral L-arginine (integrated feed) in dogs with chronic cardiovascular and kidney diseases by assessing some clinical and ematochemical parameters that are usually altered in animals affected by these chronic diseases

Study of a new formulation of functional food for dogs with chronic renal and cardiovascular diseases

FRATINI, MARGHERITA
2019-09-02

Abstract

L-arginine is an essential precursor for the production of nitric oxide (NO) which mediates the protective effects of the intact endothelium, acting as a vasodilator and endogenous antiatherogenic factor [...]. Furthermore, NO plays an important role in the regulation of the renal blood flow, glomerular filtration rate and saline homeostasis [...] The effects of arginine administration have been investigated in humans affected by cardiovascular diseases [...]. In hypertensive patients under pharmacological therapies, oral administration of arginine for six weeks resulted in a reduction in systolic and diastolic blood pressure [...] At the present time, there is a paucity of data about the role of L- arginine in chronic cardiovascular and kidney disease in dogs. On the basis of the current literature, the objective of this research was to assess the effectiveness of oral L-arginine (integrated feed) in dogs with chronic cardiovascular and kidney diseases by assessing some clinical and ematochemical parameters that are usually altered in animals affected by these chronic diseases
2-set-2019
Doctoral course in One Health
-2
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11581/433720
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