Sulfonyl indoles can be converted into 3-alkylidene-2-oxindoles using NCS as single reagent under flow chemical conditions. The conjugated oxindole derivatives are obtained as E stereoisomers in moderate to satisfactory yields. The transformation entails the oxidation of the indole ring by NCS followed by elimination of the arylsulfinic acid in order to install the exocyclic unsaturation.
Oxidative Conversion of Sulfonyl Indoles into 3-Alkylidene-2-oxindoles under Flow Chemical Conditions
M. Petrini;E. Chiurchiù;ROSSI, Federico Vittorio;A. Palmieri
2018-01-01
Abstract
Sulfonyl indoles can be converted into 3-alkylidene-2-oxindoles using NCS as single reagent under flow chemical conditions. The conjugated oxindole derivatives are obtained as E stereoisomers in moderate to satisfactory yields. The transformation entails the oxidation of the indole ring by NCS followed by elimination of the arylsulfinic acid in order to install the exocyclic unsaturation.File in questo prodotto:
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Synthesis 2018, 50, 371-376.pdf
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