Microemulsions are attractive delivery systems for therapeutic proteins and peptides due to their ability to enhance bioavailability. Although different proteins and peptides have been successfully delivered through such ternary systems, no information can be found about protein loading and the formulation stability when such microemulsions are prepared with pharmaceuticallyapproved oils and surfactants. The aim of this work was to optimise a ternary system consisting of water/ ethyl oleate/Span® 80-Tween® 80 and to determine its protein loading capacity and stability, using bovine serum albumin (BSA) as a model of biomolecule.

Water-in-Oil Microemulsions for Protein Delivery: Loading Optimization and Stability

PERINELLI, DIEGO ROMANO;CESPI, MARCO;PUCCIARELLI, Stefania;VINCENZETTI, Silvia;LOGRIPPO, SERENA;BONACUCINA, Giulia;PALMIERI, Giovanni Filippo
2017-01-01

Abstract

Microemulsions are attractive delivery systems for therapeutic proteins and peptides due to their ability to enhance bioavailability. Although different proteins and peptides have been successfully delivered through such ternary systems, no information can be found about protein loading and the formulation stability when such microemulsions are prepared with pharmaceuticallyapproved oils and surfactants. The aim of this work was to optimise a ternary system consisting of water/ ethyl oleate/Span® 80-Tween® 80 and to determine its protein loading capacity and stability, using bovine serum albumin (BSA) as a model of biomolecule.
2017
262
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11581/403852
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