Schizogyne sericea (Asteraceae) is a species endemic to the Canary Islands and traditionally employed as analgesic, astringent, anti-inflammatory and vulnerary. A comprehensive phytochemical investigation was conducted on the flowering aerial parts by analyzing both essential oil constituents and polar compounds. The essential oil was dominated by p-cymene, with the noteworthy occurrence of β-pinene and thymol esters. From the ethanolic extract eight compounds were isolated and structurally elucidated. Essential oil, polar fractions and isolates (2), (4) and (5) were separately in vitro assayed for antiproliferative activity on human tumor cell lines (A375, MDA-MB 231, HCT 116) by MTT assay, for antioxidant potential by DPPH, ABTS and FRAP assays, and for antimicrobial activity by the agar disc diffusion method. Results revealed that essential oil and compounds 1 and 2 exert a strong inhibition on tumor cells, in some cases higher than that of cisplatin. Fractions containing thymol derivatives (1 and 2) and compounds 4 and 5 displayed antioxidant activity comparable to that of Trolox, making S. sericea extract an interesting natural product with potential applications as preservative or in the treatment of diseases in which oxidative stress plays an important role.

Bioactive secondary metabolites from Schizogyne sericea (Asteraceae) endemic to Canary Islands

QUASSINTI, Luana;BRAMUCCI, Massimo;DAMIANO, SILVIA;IANNARELLI, ROMILDE;LUPIDI, Giulio;PAPA, Fabrizio;PETRELLI, Dezemona;VITALI, Luca Agostino;VITTORI, Sauro;MAGGI, Filippo
2016-01-01

Abstract

Schizogyne sericea (Asteraceae) is a species endemic to the Canary Islands and traditionally employed as analgesic, astringent, anti-inflammatory and vulnerary. A comprehensive phytochemical investigation was conducted on the flowering aerial parts by analyzing both essential oil constituents and polar compounds. The essential oil was dominated by p-cymene, with the noteworthy occurrence of β-pinene and thymol esters. From the ethanolic extract eight compounds were isolated and structurally elucidated. Essential oil, polar fractions and isolates (2), (4) and (5) were separately in vitro assayed for antiproliferative activity on human tumor cell lines (A375, MDA-MB 231, HCT 116) by MTT assay, for antioxidant potential by DPPH, ABTS and FRAP assays, and for antimicrobial activity by the agar disc diffusion method. Results revealed that essential oil and compounds 1 and 2 exert a strong inhibition on tumor cells, in some cases higher than that of cisplatin. Fractions containing thymol derivatives (1 and 2) and compounds 4 and 5 displayed antioxidant activity comparable to that of Trolox, making S. sericea extract an interesting natural product with potential applications as preservative or in the treatment of diseases in which oxidative stress plays an important role.
2016
262
File in questo prodotto:
File Dimensione Formato  
Bioactive Secondary Metabolites from Schizogyne sericea (Asteraceae) Endemic to Canary Islands.pdf

accesso aperto

Tipologia: Documento in Post-print
Licenza: DRM non definito
Dimensione 115.4 kB
Formato Adobe PDF
115.4 kB Adobe PDF Visualizza/Apri
Venditti_et_al-2016-Chemistry and Biodiversity.pdf

solo gestori di archivio

Tipologia: Versione Editoriale
Licenza: NON PUBBLICO - Accesso privato/ristretto
Dimensione 114.92 kB
Formato Adobe PDF
114.92 kB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11581/392349
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 10
  • ???jsp.display-item.citation.isi??? 9
social impact