A voltammetric method for the determination of 3-mercapto-D-2-methylpropanoyl-L-proline, a hypotensive drug whose pharmaceutical name is Captopril (CPT), in the concentration range from 9.0×10-10 M to 3×10-6 M, is described. In this range the peak current increases linearly with drug concentration even when different collection periods are used. A self-cleaning Hanging Mercury Drop Electrode (HMDE) was used and a negative Differential Pulse potential (DP) was applied to the indicator electrode. The stripping peak of CPT splits into two peaks as soon as the concentration is increased over about 10-5 M; in the oxidation DP scan, instead, this splitting is observed at a concentration of 2.0×10-4 M. Some attempts were made to verify the suitability of other techniques such as Alternating Current polarography (AC) and the use of a different electrode, the Wax-Impregnated Graphite Electrode (WIGE).

Determination of captopril using adsorptive cathodic differential pulse stripping voltammetry with the HMDE

PASSAMONTI, Paolo;
1987-01-01

Abstract

A voltammetric method for the determination of 3-mercapto-D-2-methylpropanoyl-L-proline, a hypotensive drug whose pharmaceutical name is Captopril (CPT), in the concentration range from 9.0×10-10 M to 3×10-6 M, is described. In this range the peak current increases linearly with drug concentration even when different collection periods are used. A self-cleaning Hanging Mercury Drop Electrode (HMDE) was used and a negative Differential Pulse potential (DP) was applied to the indicator electrode. The stripping peak of CPT splits into two peaks as soon as the concentration is increased over about 10-5 M; in the oxidation DP scan, instead, this splitting is observed at a concentration of 2.0×10-4 M. Some attempts were made to verify the suitability of other techniques such as Alternating Current polarography (AC) and the use of a different electrode, the Wax-Impregnated Graphite Electrode (WIGE).
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11581/249351
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