The chromatographic behavior of neutral molecules in Ion Interaction Chromatography (IIC) was theoretically investigated. The use of a potential approximation to obtain a simplified retention equation was successfully tested. The most reliable experimental literature results, concerning the retention behavior of neutral molecules in IIC, were successfully fitted by the retention equation. The wide variability among them was elucidated on the basis of the developed retention equation. A new separation strategy, to improve the selectivity of the chromatographic method, for difficult to separate mixtures of neutral eluates was proposed.

Ion interaction chromatography of neutral molecules: a potential approximation to obtain a simplified retention equation

PUCCIARELLI, Filippo;PASSAMONTI, Paolo
2001-01-01

Abstract

The chromatographic behavior of neutral molecules in Ion Interaction Chromatography (IIC) was theoretically investigated. The use of a potential approximation to obtain a simplified retention equation was successfully tested. The most reliable experimental literature results, concerning the retention behavior of neutral molecules in IIC, were successfully fitted by the retention equation. The wide variability among them was elucidated on the basis of the developed retention equation. A new separation strategy, to improve the selectivity of the chromatographic method, for difficult to separate mixtures of neutral eluates was proposed.
2001
262
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11581/114645
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