Design, synthesis, and biological evaluation of new mitonafide derivatives as potential antitumor drugs

Antonini, Ippolito; Volpini, Rosaria; Dal Ben, Diego; Lambertucci, Catia; Cristalli, Gloria

doi:10.1016/j.bmc.2008.08.027

A series of potential DNA-binding antitumor agents, 2-[omega-(alkylamino) alkyl]-6-{[omega-(alkylamino) alkyl] amino}-1H-benzo[de] isoquinolin-1,3(2H)-diones and 1,7-bis{6-[(omega-(dimethylamino) alkyl) amino]-1,3dioxo-1H-benzo[de] isoquinolin-2(3H)-yl}-4-methyl-4-azaheptanes, have been prepared as mitonafide derivatives. Their DNA-binding ability and cytotoxic activity have been evaluated. Some of the target compounds have shown high DNA affinity as well as relevant cytotoxic properties. (C) 2008 Elsevier Ltd. All rights reserved.

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Titolo:	Design, synthesis, and biological evaluation of new mitonafide derivatives as potential antitumor drugs
Autori:	ANTONINI, Ippolito VOLPINI, Rosaria DAL BEN, Diego LAMBERTUCCI, Catia CRISTALLI, Gloria
Data di pubblicazione:	2008
Rivista:	BIOORGANIC & MEDICINAL CHEMISTRY
Abstract:	A series of potential DNA-binding antitumor agents, 2-[omega-(alkylamino) alkyl]-6-{[omega-(alkylamino) alkyl] amino}-1H-benzo[de] isoquinolin-1,3(2H)-diones and 1,7-bis{6-[(omega-(dimethylamino) alkyl) amino]-1,3dioxo-1H-benzo[de] isoquinolin-2(3H)-yl}-4-methyl-4-azaheptanes, have been prepared as mitonafide derivatives. Their DNA-binding ability and cytotoxic activity have been evaluated. Some of the target compounds have shown high DNA affinity as well as relevant cytotoxic properties. (C) 2008 Elsevier Ltd. All rights reserved.
Handle:	http://hdl.handle.net/11581/112136
Appare nelle tipologie:	Articolo

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