The present study evaluated the effect of intraperitoneal injections of crude extracts of Radix pueraria (RP) on ethanol intake in genetically selected alcohol-preferring rats. Water and food sated rats were offered 10% ethanol intake for 10 h/day, during the dark phase of an inverse light-dark cycle. RP extracts reduced ethanol intake in alcohol-preferring rats. However, the dose of 75 mg/100 g body weight, that produced only minor behavioural alterations and did not modify total fluid intake, elicited only a modest attenuation (about 20%) of ethanol consumption. A more pronounced inhibition of ethanol intake was obtained following 150 and 300 mg/100 g, but these doses induced marked alterations of the gross behaviour in treated rats, which were rather immobile and apparently in a condition of malaise at least during the first hour after drug administration. Moreover, 150 mg/100 g produced a general inhibition of the ingestive behaviour, as shown by the finding that it inhibited water intake in water deprived rats and food deprived rats. Pronounced alterations on the gross behaviour were evident also in deprived rats, which were not offered 10% ethanol, thus indicating that they cannot be accounted for by an effect of RP on ethanol metabolism
Effect of Pueraria lobata (Wild) on ethanol intake of alcohol-preferring rats.
MASSI, Maurizio;PERFUMI, Marina Cecilia
1998-01-01
Abstract
The present study evaluated the effect of intraperitoneal injections of crude extracts of Radix pueraria (RP) on ethanol intake in genetically selected alcohol-preferring rats. Water and food sated rats were offered 10% ethanol intake for 10 h/day, during the dark phase of an inverse light-dark cycle. RP extracts reduced ethanol intake in alcohol-preferring rats. However, the dose of 75 mg/100 g body weight, that produced only minor behavioural alterations and did not modify total fluid intake, elicited only a modest attenuation (about 20%) of ethanol consumption. A more pronounced inhibition of ethanol intake was obtained following 150 and 300 mg/100 g, but these doses induced marked alterations of the gross behaviour in treated rats, which were rather immobile and apparently in a condition of malaise at least during the first hour after drug administration. Moreover, 150 mg/100 g produced a general inhibition of the ingestive behaviour, as shown by the finding that it inhibited water intake in water deprived rats and food deprived rats. Pronounced alterations on the gross behaviour were evident also in deprived rats, which were not offered 10% ethanol, thus indicating that they cannot be accounted for by an effect of RP on ethanol metabolismI documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
