The reductive cyclization of sulfonylalkyl indoles obtained from 2-(o-nitroaryl)indoles, provides an efficient preparation of functionalized indolo[3,2-c]quinolines. This cascade process promoted by zinc powder in acetic acid at reflux, involves a sequential nitro group reduction, a vinylogous aza-Michael reaction, and a final aromatization.
A New Synthetic Approach to the Preparation of Indolo[3,2-c]quinolines From Sulfonylalkyl Indoles
Muhammad Ehtisham Ibraheem Khan;Alessandro Palmieri
;Marino Petrini.
2026-01-01
Abstract
The reductive cyclization of sulfonylalkyl indoles obtained from 2-(o-nitroaryl)indoles, provides an efficient preparation of functionalized indolo[3,2-c]quinolines. This cascade process promoted by zinc powder in acetic acid at reflux, involves a sequential nitro group reduction, a vinylogous aza-Michael reaction, and a final aromatization.File in questo prodotto:
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