Investigations on the Use of Deep Eutectic Solvents (DESs) as Promoters for the Conjugate Addition of α-Nitroketones to Electron-Poor Alkenes

DESs were profitably investigated as solvents and promoters of the conjugate reaction addition of cyclic and acyclic α-nitroketones to a variety of electron-poor alkenes. The best results were obtained conducing the reaction in betaine:1,2-propanediol (1 :5 molar ratio) DES at room temperature, and enones were demonstrated to be the most effective Michael acceptors. The same reaction conducted by using different molar ratios of the components in this DES showed the eutectic point to be the most effective in terms of the yields observed.