β-Nitroenones can be efficiently converted into 3,5-disubstituted isoxazoles by using tin(ii)chloride dihydrate and ethyl acetate as a reducing agent and solvent, respectively. Products are obtained in good yields and several functional groups are tolerated thanks to the mild reaction conditions.
Synthesis of 3,5-disubstituted isoxazoles by domino reductive Nef reaction/cyclization of β-nitroenones
Khan M. E. I.Primo
;Cassini T. L.Secondo
;Petrini M.Penultimo
;Palmieri A.
Ultimo
2024-01-01
Abstract
β-Nitroenones can be efficiently converted into 3,5-disubstituted isoxazoles by using tin(ii)chloride dihydrate and ethyl acetate as a reducing agent and solvent, respectively. Products are obtained in good yields and several functional groups are tolerated thanks to the mild reaction conditions.File in questo prodotto:
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