A new one-pot preparation of 3,6-disubstituted pyridazines starting from β-nitro-β,γ-unsaturated ketones and hydrazine monohydrate is presented. The protocol entails two sequential steps, leading to the isolation of the title targets in satisfactory overall yields tolerating a good variety of additional functionalities.
A New One-Pot Synthesis of 3,6-Disubstituted Pyridazines Starting from β-Nitro-β,γ-Unsaturated Ketones
Marino Petrini Penultimo
;Alessandro Palmieri
Ultimo
2023-01-01
Abstract
A new one-pot preparation of 3,6-disubstituted pyridazines starting from β-nitro-β,γ-unsaturated ketones and hydrazine monohydrate is presented. The protocol entails two sequential steps, leading to the isolation of the title targets in satisfactory overall yields tolerating a good variety of additional functionalities.File in questo prodotto:
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Synthesis 2023, 55, 3204-3208.pdf
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