Gold nanorods (AuNRs) are innovative tools useful in biomedicine They can be functionalized with a variety of molecules, including specific drugs or peptides, enabling controlled transport and release. In addition, AuNRs are studied for their use in photothermal therapy and diagnostics (imaging) due to the peculiar phenomenon of Localised Surface Plasmon Resonance (LSPR), which allows them to be identified by spectroscopic techniques in the energy range where biological tissues are inactive. In this framework, AuNRs with different aspect ratios were synthesized and characterised through near-infrared (NIR) and X-ray absorption (XPS) spectroscopies and transmission electron microscopy (TEM). Furthermore, AuNRs were conjugated with copper based complex (Cu(PTA)4 F4), a promising antiviral compound, obtaining an efficiency loading of η= 55%. Their cytotoxic activity was evaluated on VERO E6 cell line by MTT assay. The data obtained confirm the AuNRs as promising carriers of hydrophobic drugs, opening up new possibilities of application in the field of medical materials.
Copper complexes delivered by gold nanorods: conjugation and cytotoxicity tests for promising antiviral systems
Maura Pellei;Carlo Santini;Jo’ Del Gobbo;
2023-01-01
Abstract
Gold nanorods (AuNRs) are innovative tools useful in biomedicine They can be functionalized with a variety of molecules, including specific drugs or peptides, enabling controlled transport and release. In addition, AuNRs are studied for their use in photothermal therapy and diagnostics (imaging) due to the peculiar phenomenon of Localised Surface Plasmon Resonance (LSPR), which allows them to be identified by spectroscopic techniques in the energy range where biological tissues are inactive. In this framework, AuNRs with different aspect ratios were synthesized and characterised through near-infrared (NIR) and X-ray absorption (XPS) spectroscopies and transmission electron microscopy (TEM). Furthermore, AuNRs were conjugated with copper based complex (Cu(PTA)4 F4), a promising antiviral compound, obtaining an efficiency loading of η= 55%. Their cytotoxic activity was evaluated on VERO E6 cell line by MTT assay. The data obtained confirm the AuNRs as promising carriers of hydrophobic drugs, opening up new possibilities of application in the field of medical materials.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
