N-glycolylneuraminic acid (Neu5Gc) is synthesized from its N-acetyl precursor (Neu5Ac) by cytidine-50- monophospho-N acetylneuraminic acid hydroxylase (CMAH). Absent in humans and ferrets, it is polymorphic in dogs. Loss of the CMAH gene generate a change in the structural profile of glycans of all tissues inducing the production of antibodies against Neu5Gc-glycans…

Possible Role of Dietary N-glycolyneuraminic Acid and Dysbiosis in Canine Enteropathy Pathogenesis

Giacomo Rossi;Lucia Biagini;Livio Galosi;Matteo Cerquetella;Alessandra Gavazza;Fiorella Carnevali
2024-01-01

Abstract

N-glycolylneuraminic acid (Neu5Gc) is synthesized from its N-acetyl precursor (Neu5Ac) by cytidine-50- monophospho-N acetylneuraminic acid hydroxylase (CMAH). Absent in humans and ferrets, it is polymorphic in dogs. Loss of the CMAH gene generate a change in the structural profile of glycans of all tissues inducing the production of antibodies against Neu5Gc-glycans…
2024
274
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11581/477903
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