N-glycolylneuraminic acid (Neu5Gc) is synthesized from its N-acetyl precursor (Neu5Ac) by cytidine-50- monophospho-N acetylneuraminic acid hydroxylase (CMAH). Absent in humans and ferrets, it is polymorphic in dogs. Loss of the CMAH gene generate a change in the structural profile of glycans of all tissues inducing the production of antibodies against Neu5Gc-glycans…
Possible Role of Dietary N-glycolyneuraminic Acid and Dysbiosis in Canine Enteropathy Pathogenesis
Giacomo Rossi;Lucia Biagini;Livio Galosi;Matteo Cerquetella;Alessandra Gavazza;Fiorella Carnevali
2024-01-01
Abstract
N-glycolylneuraminic acid (Neu5Gc) is synthesized from its N-acetyl precursor (Neu5Ac) by cytidine-50- monophospho-N acetylneuraminic acid hydroxylase (CMAH). Absent in humans and ferrets, it is polymorphic in dogs. Loss of the CMAH gene generate a change in the structural profile of glycans of all tissues inducing the production of antibodies against Neu5Gc-glycans…File in questo prodotto:
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Possible Role of Dietary N-glycolyneuraminic Acid and Dysbiosis in Canine Enteropathy Pathogenesis (2).pdf
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