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Design and analysis of steel‐concrete hybrid coupled walls with hinged base and corner components

The seismic performance of hybrid coupled walls (HCWs) made of a single reinforced concrete (RC) wall connected to two steel side columns by means of steel links is studied in this article. Steel links are designed as dissipative elements while the RC wall and the steel side columns should remain elastic. Given that previous studies highlighted the difficulties in avoiding damage at the base of the RC wall due to the concentration of bending moment, the scheme with fixed base is modified in t...

Analisi speditive per la conoscenza dell’edilizia storica: alcune applicazioni nei cantieri marchigiani post sisma 2016

The seismic crisis of 2016 showed the fragility of cultural heritage, especially in some areas that had already experienced previous catastrophic events and were in conditions of great socio-economic difficulty. A process of revision of the intervention practices consolidated over time has been launched, to achieve a degree of in-depth knowledge of the construction processes, the materials used, the intrinsic weaknesses and those linked to repeated seismic phenomena. A group of researchers f...

Sidestream-dark field videomicroscopy for the in vivo evaluation of the pulmonary alveoli and microcirculation in mechanically ventilated pigs

Introduction: Under mechanical ventilation, the pulmonary microcirculation can be affected by the expansion or collapse of alveoli, resulting in a change in pulmonary vascular resistance. Sidestream-dark field (SDF) videomicroscopy has been used in animal models to assess pulmonary microcirculation in vivo. This study aimed to evaluate whether different mechanical ventilation settings could affect the alveolar size and pulmonary vessels in a porcine model. Methods: This experimental study was...

Neoplastic Transformation of the Colon Mucosa Correlates with an Altered Expression of RAAS in Dogs

BACKGROUND: Tissue effects of the renin-angiotensin-aldosterone system (RAAS) include the regulation of cell growth and proliferation, and RAAS imbalances have been linked to cancer development and progression. RAAS components have potential as diagnostic/prognostic markers and therapeutic targets. Colonic adenomatous lesions are precursors of colorectal cancer, providing a model for carcinogenesis research. ANIMALS: Archived colon tissues from 26 dogs. METHODS: For each polyp (based on dys...

DISSECTING GBM EVOLUTION FOLLOWING STANDARD-OF-CARE BY LARGE-SCALE LONGITUDINAL SINGLE NUCLEUS RNA-SEQUENCING

The heterogeneity within tumors has long been associated with therapy failure and disease progression. Recent advances in single-cell RNA-sequencing technologies have enabled us to dissect the cellular diversity in glioblastoma (GBM). However, how these cellular programs change longitudinally under therapy remains poorly understood. To address this question, we collected and profiled a large-scale longitudinal cohort of 59 matched IDH-wildtype GBM sample pairs provided by 7 centers worldwide ...

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