ObjectivesThe aim of this study was to compare the effects of a sustained inflation alveolar recruiting maneuver (ARM) followed by 5 cmH(2)O of PEEP and a stepwise ARM, in dogs undergoing laparoscopic surgery. Materials and methodsTwenty adult dogs were enrolled in this prospective randomized clinical study. Dogs were premedicated with methadone intramuscularly (IM); anesthesia was induced with propofol intravenously (IV) and maintained with inhaled isoflurane in pure oxygen. The baseline ventilatory setting (BVS) was as follows: tidal volume of 15 mL/kg, inspiratory pause of 25%, inspiratory to expiratory ratio of 1:2, and the respiratory rate to maintain the end-tidal carbon dioxide between 45 and 55 mmHg. 10 min after pneumoperitoneum, randomly, 10 dogs underwent sustained inflation ARM followed by 5 cmH(2)O of PEEP (ARMi), while 10 dogs underwent a stepwise recruitment maneuver followed by the setting of the "best PEEP" (ARMc). Gas exchange, respiratory system mechanics, and hemodynamic were evaluated before the pneumoperitoneum induction (BASE), 10 min after the pneumoperitoneum (PP), 10 min after the recruitment (ARM), and 10 min after the pneumoperitoneum resolution (PostPP). Statistical analysis was performed with the ANOVA test (p < 0.05). ResultsStatic compliance decreased in both groups at PP (ARMc = 1.35 +/- 0.21; ARMi = 1.16 +/- 0.26 mL/cmH(2)O/kg) compared to BASE (ARMc = 1.78 +/- 0.60; ARMi = 1.66 +/- 0.66 mL/cmH(2)O/kg) and at ARM (ARMc = 1.71 +/- 0.41; ARMi = 1.44 +/- 0.84 mL/cmH(2)O/kg) and PostPP (ARMc = 1.75 +/- 0.45; ARMi = 1.89 +/- 0.59 mL/cmH(2)O/kg), and it was higher compared to PP and similar to BASE. The PaO2/FiO(2), in both groups, was higher at ARM (ARMc = 455.11 +/- 85.90; ARMi = 505.40 +/- 31.70) and PostPP (ARMc = 521.30 +/- 66.20; ARMi = 450.90 +/- 70.60) compared to PP (ARMc = 369.53 +/- 49.31; ARMi = 394.32 +/- 37.72).

Effects of two alveolar recruitment maneuvers in an "open-lung" approach during laparoscopy in dogs

Di Bella, Caterina
Primo
;
2022-01-01

Abstract

ObjectivesThe aim of this study was to compare the effects of a sustained inflation alveolar recruiting maneuver (ARM) followed by 5 cmH(2)O of PEEP and a stepwise ARM, in dogs undergoing laparoscopic surgery. Materials and methodsTwenty adult dogs were enrolled in this prospective randomized clinical study. Dogs were premedicated with methadone intramuscularly (IM); anesthesia was induced with propofol intravenously (IV) and maintained with inhaled isoflurane in pure oxygen. The baseline ventilatory setting (BVS) was as follows: tidal volume of 15 mL/kg, inspiratory pause of 25%, inspiratory to expiratory ratio of 1:2, and the respiratory rate to maintain the end-tidal carbon dioxide between 45 and 55 mmHg. 10 min after pneumoperitoneum, randomly, 10 dogs underwent sustained inflation ARM followed by 5 cmH(2)O of PEEP (ARMi), while 10 dogs underwent a stepwise recruitment maneuver followed by the setting of the "best PEEP" (ARMc). Gas exchange, respiratory system mechanics, and hemodynamic were evaluated before the pneumoperitoneum induction (BASE), 10 min after the pneumoperitoneum (PP), 10 min after the recruitment (ARM), and 10 min after the pneumoperitoneum resolution (PostPP). Statistical analysis was performed with the ANOVA test (p < 0.05). ResultsStatic compliance decreased in both groups at PP (ARMc = 1.35 +/- 0.21; ARMi = 1.16 +/- 0.26 mL/cmH(2)O/kg) compared to BASE (ARMc = 1.78 +/- 0.60; ARMi = 1.66 +/- 0.66 mL/cmH(2)O/kg) and at ARM (ARMc = 1.71 +/- 0.41; ARMi = 1.44 +/- 0.84 mL/cmH(2)O/kg) and PostPP (ARMc = 1.75 +/- 0.45; ARMi = 1.89 +/- 0.59 mL/cmH(2)O/kg), and it was higher compared to PP and similar to BASE. The PaO2/FiO(2), in both groups, was higher at ARM (ARMc = 455.11 +/- 85.90; ARMi = 505.40 +/- 31.70) and PostPP (ARMc = 521.30 +/- 66.20; ARMi = 450.90 +/- 70.60) compared to PP (ARMc = 369.53 +/- 49.31; ARMi = 394.32 +/- 37.72).
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11581/468354
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