The Cover Feature shows the use of natural deep eutectic solvents (DESs) as catalytic green solvents for the “click” Copper-catalyzed cycloaddition of azides to alkynes (CuAAc) affording 1,2,3-triazoles in excellent yields. These solvents have green properties for their low or absent volatility and toxicity and are formed from natural compounds, therefore they are biocompatible. The DESs revealed their catalytic features due to their reducing properties and their basic behavior thanks to the H-bond network, which makes the use of any base as well as sacrificial reductants superfluous. More information can be found in the Full Paper by S. V. Giofrè, M. Tiecco et al.
Cover Feature: Base‐Free Copper‐Catalyzed Azide‐Alkyne Click Cycloadditions (CuAAc) in Natural Deep Eutectic Solvents as Green and Catalytic Reaction Media (Eur. J. Org. Chem. 34/2021)
Tiecco, Matteo
;Romeo, Roberto;
2021-01-01
Abstract
The Cover Feature shows the use of natural deep eutectic solvents (DESs) as catalytic green solvents for the “click” Copper-catalyzed cycloaddition of azides to alkynes (CuAAc) affording 1,2,3-triazoles in excellent yields. These solvents have green properties for their low or absent volatility and toxicity and are formed from natural compounds, therefore they are biocompatible. The DESs revealed their catalytic features due to their reducing properties and their basic behavior thanks to the H-bond network, which makes the use of any base as well as sacrificial reductants superfluous. More information can be found in the Full Paper by S. V. Giofrè, M. Tiecco et al.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
