The development of alternative benign reaction conditions to perform multicomponent reactions is an interesting and desirable strategy to increase the sustainability of organic synthesis. In this paper, we report a new version of A3-coupling MCR for the preparation of differently substituted propargylamines starting from aldehydes, alkynes and amines in an acidic DES as reaction media, under dielectric heating, and in the presence of a tetraaza-macrocyclic silver complex as catalyst. The reaction scope is broad in terms of aldehyde partners. Electron-rich phenylacetylenes are the more reactive alkynes partners, whereas the nature of the amine is the more serious limitation as only secondary cyclic amines are tolerated.

Silver-catalysed A3-coupling reactions in phenylacetic acid/alkylamine N-oxide eutectic mixture under dielectric heating: An alternative approach to propargylamines

Tiecco M.;
2022-01-01

Abstract

The development of alternative benign reaction conditions to perform multicomponent reactions is an interesting and desirable strategy to increase the sustainability of organic synthesis. In this paper, we report a new version of A3-coupling MCR for the preparation of differently substituted propargylamines starting from aldehydes, alkynes and amines in an acidic DES as reaction media, under dielectric heating, and in the presence of a tetraaza-macrocyclic silver complex as catalyst. The reaction scope is broad in terms of aldehyde partners. Electron-rich phenylacetylenes are the more reactive alkynes partners, whereas the nature of the amine is the more serious limitation as only secondary cyclic amines are tolerated.
2022
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11581/467089
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