Synthesis of Novel 5’ Uridine-Head Amphiphiles as Models for DNA Molecular Recognition

Here we describe uridine functionalization in the 5’ position which provided new classes of cationic and non-ionic amphiphiles specifically designed to interact with DNA as transfection agents. The synthetic procedures developed to obtain the cationic uridine-head surfactants prevented intramolecular cyclization which occurs when uridine is functionalized in this position without using protecting groups in the uracil.