One of the most urgent problems of modern radiobiology is the search and development of new effective radioprotectors. Radiation damage causes physiological disturbances and profound changes in hematological indicators. The severity of such changes and the speed of development of disturbances are dose-dependent. Radioprotectors differ by their effectiveness and duration of their protective action. They should be non-toxic, effective, not cause pronounced adverse reactions, act relatively quickly and for a long time. In this regard, copper coordination compounds are of particular interest. The main biogenic role of copper is to participate in the processes of hematopoiesis. It is involved in the neutralization of the toxins of microorganisms, as well as prolongs the action of antibacterial medications, and reduces inflammatory reactions. Copper complexes have low toxicity and pronounced radioprotective properties. The aim of the study is to identify the possible radioprotective effects of the bis[bis(3,5-dimethylpyrazol-1-yl)acetato]copper(II) complex, based on cytogenetic analysis. As a result of cytogenetic studies, it was found that Cu[HC(COO)(pzMe2)2]2 has the ability to prevent or weaken the effect of ionizing radiation. The findings were also confirmed by survival assessments (80%). It can be concluded that this compound promotes reparative processes in the bone marrow cells of irradiated animals.

Changes in cytogenetic indicators promoted by the copper(II) complex Cu[HC(COO)(pzMe2)2]2 before irradiation

Santini, Carlo;Pellei, Maura;
2022-01-01

Abstract

One of the most urgent problems of modern radiobiology is the search and development of new effective radioprotectors. Radiation damage causes physiological disturbances and profound changes in hematological indicators. The severity of such changes and the speed of development of disturbances are dose-dependent. Radioprotectors differ by their effectiveness and duration of their protective action. They should be non-toxic, effective, not cause pronounced adverse reactions, act relatively quickly and for a long time. In this regard, copper coordination compounds are of particular interest. The main biogenic role of copper is to participate in the processes of hematopoiesis. It is involved in the neutralization of the toxins of microorganisms, as well as prolongs the action of antibacterial medications, and reduces inflammatory reactions. Copper complexes have low toxicity and pronounced radioprotective properties. The aim of the study is to identify the possible radioprotective effects of the bis[bis(3,5-dimethylpyrazol-1-yl)acetato]copper(II) complex, based on cytogenetic analysis. As a result of cytogenetic studies, it was found that Cu[HC(COO)(pzMe2)2]2 has the ability to prevent or weaken the effect of ionizing radiation. The findings were also confirmed by survival assessments (80%). It can be concluded that this compound promotes reparative processes in the bone marrow cells of irradiated animals.
2022
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11581/464531
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