Electrochemical aptasensing strategy based on a multivariate polymertitanium-metal-organic framework for zearalenone analysis

An electrochemical aptasensing strategy was developed with a novel bioplatform based on a multivariate titanium metal-organic framework, i.e. MTV polyMOF(Ti), to detect zearalenone (ZEN). MTV polyMOF(Ti) was prepared by using mixed linkers of polyether polymer (pbdc-xa or L8, pbdc = poly(1,4-benzenedicarboxylate) and 1,4-benzenedicarboxylic acid (H2bdc or L0) as well as tetrabutyl titanate as nodes (MTV polyMOF(Ti)-L8,0). Compared with Ti-MOFs synthesized by using the single ligand of L8 or L0, MTV polyMOF(Ti)-L8,0 shows more porous structure assembled with multilayered nanosheets. In light of the improved electrochemical activity and strong bioaffinity to the aptamer, the aptasensor based on MTV polyMOF(Ti)-L8,0 shows excellent performance for detecting ZEN with the ultralow detection limit at fg mL-1 level in the linear range of 10 fg mL-1 to 10 ng mL-1, along with good selectivity, reproducibility, stability, regenerability, and applicability.