Despite critical advances in our understanding of the mechanisms underlying addiction, there are no treatments to cure addicts, especially concerning cocaine. In rats, deep brain stimulation (DBS) of the subthalamic nucleus (STN) reduces the motivation to consume cocaine, escalation of its consumption and its compulsive seeking, important criteria for addiction observed in human addicts, through cellular mechanisms still unknown. Cocaine alters excitatory neuroplasticity in many brain structures. Thus, by combining behavioral, electrophysiological and optogenetic approaches, I will determine how DBS can modify cellular alterations induced by cocaine in the STN and the contribution of its excitatory neurons, or afferences, to the effects of DBS. This project will therefore aim to characterize new cellular mechanisms underlying the beneficial effects of STN DBS in addiction.

Generic Call 2019, French National Research Agency

Nazzareno Cannella
2019-01-01

Abstract

Despite critical advances in our understanding of the mechanisms underlying addiction, there are no treatments to cure addicts, especially concerning cocaine. In rats, deep brain stimulation (DBS) of the subthalamic nucleus (STN) reduces the motivation to consume cocaine, escalation of its consumption and its compulsive seeking, important criteria for addiction observed in human addicts, through cellular mechanisms still unknown. Cocaine alters excitatory neuroplasticity in many brain structures. Thus, by combining behavioral, electrophysiological and optogenetic approaches, I will determine how DBS can modify cellular alterations induced by cocaine in the STN and the contribution of its excitatory neurons, or afferences, to the effects of DBS. This project will therefore aim to characterize new cellular mechanisms underlying the beneficial effects of STN DBS in addiction.
2019
Malgré des avancées critiques dans notre compréhension des mécanismes sous-tendant l’addiction, il n’existe pas de traitement permettant de soigner les toxicomanes, notamment à la cocaïne. Chez le rat, la stimulation cérébrale profonde (SCP) du noyau subthalamique (NST) réduit la motivation a  consommer la cocaïne, l’escalade de sa consommation ainsi que sa recherche compulsive, des critères importants de l’addiction chez l’homme, par des mécanismes cellulaires encore inconnus. Or, la cocaïne modifie la neuroplasticité excitatrice dans de nombreuses structures cérébrales. En combinant des approches comportementales, électrophysiologiques et optogénétiques, je déterminerai comment la SCP modifie les altérations induites par la cocaïne dans le NST et la contribution de ses neurones, et de ses afférences excitatrices, dans les effets de la SCP. Ce projet permettra de caractériser de nouveaux mécanismes cellulaires sous-tendant les effets bénéfiques de la SCP du NST dans l’addiction
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11581/447163
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