CHANGES IN PERIPHERAL BLOOD AND CYTOGENETIC INDICATORS DURING THE APPLICATION OF COMPOUNDS OF THE COPPER-ORGANIC COMPLEXES TO IRRADIATION

Basing on the survival results, average life expectancy, cytogenetic and hematological indicators, it can be concluded that study complexes demonstrate noticeable radioprotective properties. Both complexes showed identical effects on experimental animals according to all observed criteria. In eruptive phase, on early dates of analysis (3rd and 7th days) both compounds soften the damaging effects of radiation with both doses which is especially obvious in significant shifts of mitotic index and CA in comparison with control data. On the last dates of observation (14th and 30th days) many data of analysis (MI, red blood readings) approached the standard data (norm), CA and number of leucocytes in comparison with the control data, demonstrate statistically significant difference. Based on the results obtained, it can be assumed that the studied Cu-ligands effectively promote reparative processes in bone marrow cells and have the properties of pronounced radiomodifiers.