The smooth preparation of β/γ‐substituted ketones has been carried out by using a three‐step continuous flow synthesis involving the initial photocatalyzed addition of an aldehyde onto phenyl vinyl sulfone. The resulting β‐ketosulfones were then elaborated in flow to prepare in situ an enone upon basic elimination of the sulfonyl group and then to give γ‐nitroketones, a 4‐chromanone, and β‐(3‐indolyl)ketones in moderate to good yields.
Multi-Step Continuous Flow Synthesis of beta/gamma-Substituted Ketones
Serena Gabrielli;Alessandro Palmieri;
2018-01-01
Abstract
The smooth preparation of β/γ‐substituted ketones has been carried out by using a three‐step continuous flow synthesis involving the initial photocatalyzed addition of an aldehyde onto phenyl vinyl sulfone. The resulting β‐ketosulfones were then elaborated in flow to prepare in situ an enone upon basic elimination of the sulfonyl group and then to give γ‐nitroketones, a 4‐chromanone, and β‐(3‐indolyl)ketones in moderate to good yields.File in questo prodotto:
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ChemPhotoChem 2018, 2, 847–850.pdf
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