Tetracyclines were discovered over 70 years ago and their use resulted in the emergence of tetracycline-resistance microorganisms; however, it has been hypothesized that tetracycline-resistance may have originated in the environment, and that determinants were transferred to the human gut microbiota. Ancient microbiomes represent an opportunity to explore the transmission of tetracycline-resistance determinants from the environment to humans. In the present study, tetracycline-like resistomes of three pre-Inca/Inca (10–15th centuries), and five Italian nobility (15–16th centuries) mummies were characterized using high-throughput sequencing. Sequences exhibited low homology to present-day determinants. Results may aid in the understanding of the evolution of tetracycline-resistance.
Tetracycline-like resistome of ancient human guts
Stefania Luciani;Isolina Marota;
2018-01-01
Abstract
Tetracyclines were discovered over 70 years ago and their use resulted in the emergence of tetracycline-resistance microorganisms; however, it has been hypothesized that tetracycline-resistance may have originated in the environment, and that determinants were transferred to the human gut microbiota. Ancient microbiomes represent an opportunity to explore the transmission of tetracycline-resistance determinants from the environment to humans. In the present study, tetracycline-like resistomes of three pre-Inca/Inca (10–15th centuries), and five Italian nobility (15–16th centuries) mummies were characterized using high-throughput sequencing. Sequences exhibited low homology to present-day determinants. Results may aid in the understanding of the evolution of tetracycline-resistance.File | Dimensione | Formato | |
---|---|---|---|
Tetracycline-like resistome of ancient human guts.pdf
accesso aperto
Tipologia:
Versione Editoriale
Licenza:
PUBBLICO - Creative Commons
Dimensione
479.92 kB
Formato
Adobe PDF
|
479.92 kB | Adobe PDF | Visualizza/Apri |
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.