Byproducts of industrial hemp (Cannabis sativa L.), including inflorescences, represent an exploitable material to produce niche products for the pharmaceutical, nutraceutical, cosmetic and agrochemical industries. One of these is the hemp essential oil, whose composition can be properly modulated on an industrial level by optimizing the extractive conditions and sample pretreatment. This allows to achieve high concentrations of bioactive compounds, such as cannabidiol (CBD) and sesquiterpenes [e.g. (E)-caryophyllene] which exert documented anti-inflammatory, anticancer, immunomodulatory and antinociceptive effects [1-3]. In the present work, we evaluated the effects of type of distillation apparatus, status of conservation of the plant material, grinding and sample-pretreatment with microwave and heat, on the chemical profile of hemp essential oil obtained from inflorescences of monoecious cv. Felina 32. Furthermore, moving from the concept that hemp inflorescences have evolved as a natural weapon against phytophagous insects, secreting important secondary metabolites such as cannabinoids and volatile terpenes, herein we assayed the potential of its essential oil as a botanical insecticide. The oil was tested against the filariasis vector Culex quinquefasciatus, the peach-potato aphid Myzus persicae, the housefly Musca domestica and the tobacco cutworm Spodoptera littoralis. To prove its harmlessness on non-target invertebrates, it was tested on the multicolored Asian lady beetle, Harmonia axyridis, and Eisenia foetida earthworms and compared with cypermethrin as the positive control. Overall, results give new insights into the exploitation of hemp byproducts in different fields such as pharmaceuticals, nutraceuticals, and cosmetics. Moreover, they shed light on the possible utilization of the crop residue of industrial hemp as a source of botanical insecticides to be used in Integrated Pest Management and organic agriculture, particularly against aphids and houseflies.
Recovery of bioactive products from industrial hemp (Cannabis sativa L.) waste: CBD-rich essential oils and eco-friendly biopesticides
F. Maggi;D. Fiorini;M. Nabissi;SANTINI, GIUSEPPE;R. Petrelli;L. Cappellacci;
2018-01-01
Abstract
Byproducts of industrial hemp (Cannabis sativa L.), including inflorescences, represent an exploitable material to produce niche products for the pharmaceutical, nutraceutical, cosmetic and agrochemical industries. One of these is the hemp essential oil, whose composition can be properly modulated on an industrial level by optimizing the extractive conditions and sample pretreatment. This allows to achieve high concentrations of bioactive compounds, such as cannabidiol (CBD) and sesquiterpenes [e.g. (E)-caryophyllene] which exert documented anti-inflammatory, anticancer, immunomodulatory and antinociceptive effects [1-3]. In the present work, we evaluated the effects of type of distillation apparatus, status of conservation of the plant material, grinding and sample-pretreatment with microwave and heat, on the chemical profile of hemp essential oil obtained from inflorescences of monoecious cv. Felina 32. Furthermore, moving from the concept that hemp inflorescences have evolved as a natural weapon against phytophagous insects, secreting important secondary metabolites such as cannabinoids and volatile terpenes, herein we assayed the potential of its essential oil as a botanical insecticide. The oil was tested against the filariasis vector Culex quinquefasciatus, the peach-potato aphid Myzus persicae, the housefly Musca domestica and the tobacco cutworm Spodoptera littoralis. To prove its harmlessness on non-target invertebrates, it was tested on the multicolored Asian lady beetle, Harmonia axyridis, and Eisenia foetida earthworms and compared with cypermethrin as the positive control. Overall, results give new insights into the exploitation of hemp byproducts in different fields such as pharmaceuticals, nutraceuticals, and cosmetics. Moreover, they shed light on the possible utilization of the crop residue of industrial hemp as a source of botanical insecticides to be used in Integrated Pest Management and organic agriculture, particularly against aphids and houseflies.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
