A drug delivery system based on fully biodegradable thermosensitive hydrogels enabling controlled antibiotic release may support the management of implant-associated infections. In this work, the lipopeptide antibiotic daptomycin was encapsulated in hydrogel networks consisting of vinyl sulfonated triblock copolymers of PEG-p(HPMAm-lac1,2) and thiolated hyaluronic acid. High concentrations of active daptomycin exceeding the minimum biofilm eradicating concentration were sustainably eluted from the biodegradable carrier.
Daptomycin-loaded biodegradable thermosensitive hydrogels enhance drug stability and foster bactericidal activity against Staphylococcus aureus
Casadidio, Cristina;BUTINI, MARIA EUGENIA;Censi, Roberta;Di Martino, Piera
2018-01-01
Abstract
A drug delivery system based on fully biodegradable thermosensitive hydrogels enabling controlled antibiotic release may support the management of implant-associated infections. In this work, the lipopeptide antibiotic daptomycin was encapsulated in hydrogel networks consisting of vinyl sulfonated triblock copolymers of PEG-p(HPMAm-lac1,2) and thiolated hyaluronic acid. High concentrations of active daptomycin exceeding the minimum biofilm eradicating concentration were sustainably eluted from the biodegradable carrier.File in questo prodotto:
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77_DAPTOMYCIN-LOADEDBIODEGRADABLE THERMOSENSITIVE HYDROGELS ENHANCE DRUG STABILITY AND FOSTER BACTERICIDAL ACTIVITY AGAINST STAPHYLOCOCCUS AUREUS.pdf
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