Dicationic ruthenium(II)–p-cymene complexes containing curcumin ligands (curcH = curcumin, bdcurcH = bisdemethoxycurcumin) and ionic N-methyl-1,3,5-triaza-7-phosphaadamantane [PTA-Me]X (X = BF4 or I) have been synthesized and fully characterized for the first time. The solid-state structure of [Ru(p-cym)(curc)(PTA-Me)][SO3CF3][BF4] has also been determined by single-crystal X-ray diffraction. Modest antiproliferative activities of the complexes were observed against cisplatin-sensitive and cisplatin-resistant human ovarian carcinoma cells (A2780 and A2780cisR, respectively) and nontumorigenic human embryonic kidney (HEK293) cells.

Dicationic Ruthenium(II)-Arene-Curcumin Complexes Containing Methylated 1,3,5-Triaza-7-phosphaadamantane: Synthesis, Structure, and Cytotoxicity

PETTINARI, Riccardo;CONDELLO, FRANCESCA;MARCHETTI, Fabio;PETTINARI, Claudio;
2017-01-01

Abstract

Dicationic ruthenium(II)–p-cymene complexes containing curcumin ligands (curcH = curcumin, bdcurcH = bisdemethoxycurcumin) and ionic N-methyl-1,3,5-triaza-7-phosphaadamantane [PTA-Me]X (X = BF4 or I) have been synthesized and fully characterized for the first time. The solid-state structure of [Ru(p-cym)(curc)(PTA-Me)][SO3CF3][BF4] has also been determined by single-crystal X-ray diffraction. Modest antiproliferative activities of the complexes were observed against cisplatin-sensitive and cisplatin-resistant human ovarian carcinoma cells (A2780 and A2780cisR, respectively) and nontumorigenic human embryonic kidney (HEK293) cells.
2017
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11581/403183
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