Many diseases are the result of the Th2-phenotype immune response directed against an antigen, by triggering an immune-complex disease. In this situation, the manifestation of disease is not closely related to the pathogen, but to an inappropriate host immune response. Leishmaniasis is one of the most classic examples. We investigated the possibility of clinical recovery in dogs with Leishmaniasis following stimulation of the Th1-type immune response. The immunomodulation was based on the exaltation of cell-mediated immune response, by extract of Mycobacteria, ...
Th1 paradigm: redirect the cell-mediated immune response in a typical Th2 disease such as Leishmaniasis
Scarpona, S;Berardi, S;Rossi, G
2016-01-01
Abstract
Many diseases are the result of the Th2-phenotype immune response directed against an antigen, by triggering an immune-complex disease. In this situation, the manifestation of disease is not closely related to the pathogen, but to an inappropriate host immune response. Leishmaniasis is one of the most classic examples. We investigated the possibility of clinical recovery in dogs with Leishmaniasis following stimulation of the Th1-type immune response. The immunomodulation was based on the exaltation of cell-mediated immune response, by extract of Mycobacteria, ...File in questo prodotto:
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