Many biological phenomena are inherently multiscale (MS) - i.e. they are characterised by interactions involving simultaneously different spatial and temporal scales. The needs of describing systems in a MS fashion and, more in general, MS problems across multiple scientific disciplines require a common modelling approach being able to (i) unify the common principles arising in general in MS scenarios (e.g. scale representation, scale separation and inter-scale interaction), (ii) support the effective combination of various single-scale models through well-defined scale coupling procedures, and consequently (iii) help to model and to simulate MS scenarios in a rigorous and systematic way. Complex Automata (CxA) constitute a well-defined paradigm for multiscale modelling that goes towards the above mentioned characteristics. BIOSHAPE, a 3D spatial geometric-based simulator, has been also defined as an independent modelling and simulation environment naturally able to represent, in the same model, different levels of multiscale systems. In this work we show that BIOSHAPE can be used to perform multiscale modelling and simulation using the same core ideas of the CxA approach.

Uniformity in Multiscale Models: From Complex Automata to BioShape

CACCIAGRANO, Diletta Romana;CORRADINI, Flavio;MERELLI, Emanuela;TESEI, Luca
2017-01-01

Abstract

Many biological phenomena are inherently multiscale (MS) - i.e. they are characterised by interactions involving simultaneously different spatial and temporal scales. The needs of describing systems in a MS fashion and, more in general, MS problems across multiple scientific disciplines require a common modelling approach being able to (i) unify the common principles arising in general in MS scenarios (e.g. scale representation, scale separation and inter-scale interaction), (ii) support the effective combination of various single-scale models through well-defined scale coupling procedures, and consequently (iii) help to model and to simulate MS scenarios in a rigorous and systematic way. Complex Automata (CxA) constitute a well-defined paradigm for multiscale modelling that goes towards the above mentioned characteristics. BIOSHAPE, a 3D spatial geometric-based simulator, has been also defined as an independent modelling and simulation environment naturally able to represent, in the same model, different levels of multiscale systems. In this work we show that BIOSHAPE can be used to perform multiscale modelling and simulation using the same core ideas of the CxA approach.
2017
262
File in questo prodotto:
File Dimensione Formato  
JCA (SB) 02 CACCIAGRANO V1.pdf

solo gestori di archivio

Descrizione: Full Text
Tipologia: Documento in Post-print
Licenza: NON PUBBLICO - Accesso privato/ristretto
Dimensione 3.29 MB
Formato Adobe PDF
3.29 MB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11581/398499
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 1
  • ???jsp.display-item.citation.isi??? 1
social impact