Antiglycative activity of sulforaphane: A new avenue to counteract neurodegeneration?

Since no drugs are available to counteract Alzheimer's disease progression, today the research focus has shifted to nutraceutical compounds as an alternative form of prevention/treatment. The isothiocyanate sulforaphane (SF), abundant in Cruciferous vegetables, has received considerable attention because of its protective activity in different in vitro and in vivo animal models of neurodegeneration . Moreover, SF bioavailability in the central nervous system have been widely demonstrated . As no studies have been carried out to elucidate the effect of SF in counteracting glycative damage in neurons, we investigated the protective effects of SF against MG-induced glycative stress in neuroblastoma SH-SY5Y cells focusing on different intracellular targets.