A ruthenium(II) p-cymene derivative of quercetin was synthesized and functionally tested for cholesterol-lowering ability via direct 3-hydroxy-3-methyl-glutaryl-CoA reductase (HMGR) inhibition. Ruthenium complexation dramatically increased the inhibition potency of the parent quercetin toward HMGR, with a consequent enhancement of the cholesterol-lowering effect in hepatic cells.
A ruthenium derivative of quercetin with enhanced cholesterol-lowering activity
CUCCIOLONI, Massimiliano;BONFILI, LAURA;MOZZICAFREDDO, MATTEO;CECARINI, Valentina;PETTINARI, Riccardo;CONDELLO, FRANCESCA;PETTINARI, Claudio;MARCHETTI, Fabio;ANGELETTI, Mauro;ELEUTERI, Anna Maria
2016-01-01
Abstract
A ruthenium(II) p-cymene derivative of quercetin was synthesized and functionally tested for cholesterol-lowering ability via direct 3-hydroxy-3-methyl-glutaryl-CoA reductase (HMGR) inhibition. Ruthenium complexation dramatically increased the inhibition potency of the parent quercetin toward HMGR, with a consequent enhancement of the cholesterol-lowering effect in hepatic cells.File in questo prodotto:
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100 RCS Adv 2016, 6, 39636–39641.pdf
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