A ruthenium(II) p-cymene derivative of quercetin was synthesized and functionally tested for cholesterol-lowering ability via direct 3-hydroxy-3-methyl-glutaryl-CoA reductase (HMGR) inhibition. Ruthenium complexation dramatically increased the inhibition potency of the parent quercetin toward HMGR, with a consequent enhancement of the cholesterol-lowering effect in hepatic cells.
|Titolo:||A ruthenium derivative of quercetin with enhanced cholesterol-lowering activity|
|Data di pubblicazione:||2016|
|Appare nelle tipologie:||Articolo|