An integrated FT-ICR and computational approach has been employed to investigate the gas phasestructure and reactivity of ESI-formed complexes between organic and inorganic acids (HX) and a K+-containing hexaazamacrocycle (M). Two limiting structures are available to those complexes, either theclassical [MK+·XH] or the zwitterionic [MH+·K+·X−] one, with the latter prevailing over the first by increas-ing the gas-phase acidity of the HX ligand. Both structures undergo the HX displacement when reactingwith 2,4-pentanedione (P0) and its 1,1,1-trifluoro (P3) and 1,1,1,5,5,5-hexafluoro (P6) derivatives. TheHX displacement efficiency is found to depend not only on the specific structure of the complex, butalso on the acid/base properties of the diones. Among them, P3 displays the lowest reactivity towardsthe [MK+·XH] complexes. These findings are consistent with the co-existence of a direct HA-to-HX and abase-catalyzed A−-to-HX substitution channels. The P0 < P3 < P6 reactivity order, observed towards thezwitterionic [MH+·K+·X−] complexes, points to a HX displacement mechanism whose rate-determiningstep involves the prototropic transfer from HA to the X−moiety in the encounter complex. The presentstudy provides an extremely rare piece of information on reactive events taking place on contact ion pairs(K+X−) inside a monotopic receptor (MH+).
|Titolo:||Reactivity of Contact Ion Pairs in a Charged Monotopic Receptor|
|Data di pubblicazione:||2017|
|Appare nelle tipologie:||Articolo|