Opioid drugs are potent analgesics. However, their chronic use leads to the rapid development of tolerance to their analgesic effects and subsequent increase of significant side effects, including drug dependence and addiction. Here, we investigated the role of PPARγ in the development of analgesic tolerance to morphine in mice.
Analgesic tolerance to morphine is regulated by PPARγ
DE GUGLIELMO, Giordano;KALLUPI, MARSIDA;SCUPPA, GIULIA;STOPPONI, SERENA;CICCOCIOPPO, Roberto
2014-01-01
Abstract
Opioid drugs are potent analgesics. However, their chronic use leads to the rapid development of tolerance to their analgesic effects and subsequent increase of significant side effects, including drug dependence and addiction. Here, we investigated the role of PPARγ in the development of analgesic tolerance to morphine in mice.File in questo prodotto:
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