The α3β4 subtype of nicotinic acetylcholine receptors (nAChRs) has been implicated in mediating nicotine reinforcement processes. AT-1001 has been recently described as a high-affinity and selective α3β4 nAChR antagonist that blocks nicotine self-administration in rats. The aim of this study was to investigate the mechanism of action underlying the nicotine-suppressive effects of AT-1001.

AT-1001: a high-affinity α3β4 nAChR ligand with novel nicotine-suppressive pharmacology

CIPPITELLI, Andrea;CICCOCIOPPO, Roberto;
2015-01-01

Abstract

The α3β4 subtype of nicotinic acetylcholine receptors (nAChRs) has been implicated in mediating nicotine reinforcement processes. AT-1001 has been recently described as a high-affinity and selective α3β4 nAChR antagonist that blocks nicotine self-administration in rats. The aim of this study was to investigate the mechanism of action underlying the nicotine-suppressive effects of AT-1001.
2015
262
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11581/387826
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